Privacy preservation using game theory in e-health application

International audienceIn the domain of the new e-health applications, the ubiquitous nature of intelligent devices raises legitimate questions about the privacy of persons, and how to cope with the heterogeneity of user and application requirements in terms of security services. This requires the development of adaptive, context-aware and user-centric security solutions. Recent e-health applications (M2M/IoT/Web) permit remote monitoring of patient health, medical treatments, fitness information and parameters, alarm triggering, etc. Since the monitored device is tightly related to a human being, new changes arise regarding communications facilities constraints, private data protection, trust relationships, etc. In this work, we propose a Markovian game between data holder and data requester, in a weight loss program, to protect data privacy. We aim to reach a compromise between privacy concessions made by data holder and incentive motivation proposed by data requester. Finally, we show numerical results of executed experiments to evaluate the proposed model

A systemic and cognitive vision for IoT security: a case study of military live simulation and security challenges

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A Roadmap for Security Challenges in Internet of Things

International audienceUnquestionably, communicating entities (objects, or things) in the Internet of Things (IoT) context, are acquiring an active role in human activities, systems and processes. The high connectivity of intelligent objects and their severe constraints lead to many security challenges, which are not included into the classical formulation of security problems and solutions. "Security Shield for Internet of Things" has been identified by DARPA (Defense Advanced Research Projects Agency) as one of the four projects with a potential broader impact larger than the Internet itself 1. To help interested researchers to contribute to this research area, an IoT security roadmap overview is presented in this work based on a novel cognitive and systemic approach. The role of each component of the approach will be explained and interactions with the other main components of the proposed scheme and their impact on the overall system will be detailed. A case study will be presented to highlight components and interactions of the systemic and cognitive approach. Then, security questions about privacy, trust, identification and access control will be discussed. According to the novel taxonomy of IoT framework, different research challenges will be highlighted, important solutions and research activities will be exposed, and interesting research directions will be proposed. In addition, current standardization activities will be surveyed and discussed to ensure security of IoT components and applications

A Markov game privacy preserving model in retail applications

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A novel PEX1 mutation in a Moroccan family with Zellweger spectrum disorders

International audienceMutations in the PEX1 gene are usually associated with recessive inherited diseases including Zellweger spectrum disorders. In this work, we identified a new pathogenic missense homozygous PEX1 mutation (p.Leu1026Pro, c.3077T>C) in two Moroccan syndromic deaf siblings from consanguineous parents. This variation is located in the P-loop containing nucleoside triphosphate hydrolase of protein domain and probably causes an alteration in the hydrolysis of ATP

Two novel homozygous missense mutations identified in the BSND gene in Moroccan patients with Bartter's syndrome

Objectives: Hearing loss (HL) is one of the most common sensorineural disorders. In the present study, we identified two novel missense mutations in BSND gene causing Bartter syndrome type IV which is a genetic disease with an autosomal recessive transmission, characterized by hypokalaemia, metabolic alkalosis, an elevation in plasma renin activity and hyperaldosteronism as well as sensorineural deafness.Methods: Whole-exome sequencing was performed to study the genetic causes of Hearing loss in two unrelated patients from two Moroccan families.Results: The two novel homozygous mutations p.Arg8Gly (c.22C > G), p.Thr36Asn (c.107C > A) in exon 1 of BSND gene which encodes barttin were identified in 7 patients belonging to two unrelated families originated from central region of Morocco.Conclusion: We identified two novel missense mutations p.Arg8Gly and p.Thr36Asn in exon 1 of BSND gene; both mutations were described for the first time in Moroccan patients with Bartter syndrome type IV

Further Evidence for the Implication of the MET Gene in Non-Syndromic Autosomal Recessive Deafness

International audienceMutations in the mesenchymal epithelial transition factor (MET) gene are frequently associated with multiple human cancers but can also lead to human non-syndromic autosomal recessive deafness (DFNB97). In the present study, we identified a novel homozygous missense mutation in the METgene causing a non-syndromic hearing impairment DFNB97 form. Whole-exome sequencing was performed to determine the genetic causes of hearing loss in a Moroccan consanguineous family with an affected daughter. The structural analysis of native and mutant in the SEMA domain of the MET receptor was investigated using a molecular dynamics simulation (MDS) approach. We identified a novel pathogenic homozygous c.948A>G (p.Ile316Met) mutation in the MET gene in one deaf Moroccan young girl carrying a total bilateral non-syndromic hearing impairment. The results of the MDS approach show that an Ile316Met mutation in the SEMA domain leads to protein flexibility loss. This may produce a major impact on the structural conformation of the MET receptor, which also affects the function and binding site of the receptor. This is the first time that a mutation in the MET gene is described in a Moroccan family. Moreover, this study reports the second family in the world associating deafness and mutation in the MET gene

Novel Mutation in AIFM1 Gene Associated with X-Linked Deafness in a Moroccan Family

International audienceIntroduction: Auditory neuropathy is a hearing disorder where outer hair cell function within the cochlea is normal, but inner hair cell and/or the auditory nerve function is disrupted. It is a heterogeneous disorder, which can have either congenital or acquired causes.Methods: We found a disease-segregating mutation in the X-linked AIFM1 gene through whole-exome sequencing, encoding the apoptosis-inducing factor mitochondrion-associated 1.Results: The impact of the c.1045A>G; p.(Ser349Gly) mutation on the AIFM1 protein was predicted using different bioinformatics tools. The pedigree analysis in the examined family was consistent with X-linked dominant inheritance.Discussion/conclusion: To our knowledge, this is the first study that identifies a mutation in the AIFM1 gene in Moroccan patients suffering from X-linked auditory neuropath

A novel mutation in SLITRK6 causes deafness and myopia in a Moroccan family

International audienceDeafness and myopia syndrome is characterized by moderate-profound, bilateral, congenital or prelingual deafness and high myopia. Autosomal recessive non-syndromic hearing loss is one of the most prevalent human genetic sensorineural defects. Myopia is by far the most common human eye disorder that is known to have a clear heritable component. The analysis of the two exons of SLITRK6 gene in a Moroccan family allowed us to identify a novel single deleterious mutation c.696delG, p.Trp232Cysfs*10 at homozygous state in the exon 2 of the SLITRK6, a gene reported to cause deafness and myopia in various populations