Decoding grip type and action goal during the observation of reaching-grasping actions: A multivariate fMRI study

During execution and observation of reaching-grasping actions, the brain must encode, at the same time, the final action goal and the type of grip necessary to achieve it. Recently, it has been proposed that the Mirror Neuron System (MNS) is involved not only in coding the final goal of the observed action, but also the type of grip used to grasp the object. However, the specific contribution of the different areas of the MNS, at both cortical and subcortical level, in disentangling action goal and grip type is still unclear. Here, twenty human volunteers participated in an fMRI study in which they performed two tasks: (a) observation of four different types of actions, consisting in reaching-to-grasp a box handle with two possible grips (precision, hook) and two possible goals (open, close); (b) action execution, in which participants performed grasping actions similar to those presented during the observation task. A conjunction analysis revealed the presence of shared activated voxels for both action observation and execution within several cortical areas including dorsal and ventral premotor cortex, inferior and superior parietal cortex, intraparietal sulcus, primary somatosensory cortex, and cerebellar lobules VI and VIII. ROI analyses showed a main effect for grip type in several premotor and parietal areas and cerebellar lobule VI, with higher BOLD activation during observation of precision vs hook actions. A grip x goal interaction was also present in the left inferior parietal cortex, with higher BOLD activity during precision-to-close actions. A multivariate pattern analysis (MVPA) revealed a significant accuracy for the grip model in all ROIs, while for the action goal model, significant accuracy was observed only for left inferior parietal cortex ROI. These findings indicate that a large network involving cortical and cerebellar areas is involved in the processing of type of grip, while final action goal appears to be mainly processed within the inferior parietal region, suggesting a differential contribution of the areas activated in this study

Structural connectivity associated with the sense of body ownership: a diffusion tensor imaging and disconnection study in patients with bodily awareness disorder

The brain mechanisms underlying the emergence of a normal sense of body ownership can be investigated starting from pathological conditions in which body awareness is selectively impaired. Here, we focused on pathological embodiment, a body ownership disturbance observed in brain-damaged patients who misidentify other people's limbs as their own. We investigated whether such body ownership disturbance can be classified as a disconnection syndrome, using three different approaches based on diffusion tensor imaging: (i) reconstruction of disconnectome maps in a large sample (N = 70) of stroke patients with and without pathological embodiment; (ii) probabilistic tractography, performed on the age-matched healthy controls (N = 16), to trace cortical connections potentially interrupted in patients with pathological embodiment and spared in patients without this pathological condition; (iii) probabilistic 'in vivo' tractography on two patients without and one patient with pathological embodiment. The converging results revealed the arcuate fasciculus and the third branch of the superior longitudinal fasciculus as mainly involved fibre tracts in patients showing pathological embodiment, suggesting that this condition could be related to the disconnection between frontal, parietal and temporal areas. This evidence raises the possibility of a ventral self-body recognition route including regions where visual (computed in occipito-temporal areas) and sensorimotor (stored in premotor and parietal areas) body representations are integrated, giving rise to a normal sense of body ownership

Decoding point-light displays and fully visible hand grasping actions within the action observation network

Action observation typically recruits visual areas and dorsal and ventral sectors of the parietal and premotor cortex. This network has been collectively termed as extended action observation network (eAON). Within this network, the elaboration of kinematic aspects of biological motion is crucial. Previous studies investigated these aspects by presenting subjects with point-light displays (PLDs) videos of whole-body movements, showing the recruitment of some of the eAON areas. However, studies focused on cortical activation during observation of PLDs grasping actions are lacking. In the present functional magnetic resonance imaging (fMRI) study, we assessed the activation of eAON in healthy participants during the observation of both PLDs and fully visible hand grasping actions, excluding confounding effects due to low-level visual features, motion, and context. Results showed that the observation of PLDs grasping stimuli elicited a bilateral activation of the eAON. Region of interest analyses performed on visual and sensorimotor areas showed no significant differences in signal intensity between PLDs and fully visible experimental conditions, indicating that both conditions evoked a similar motor resonance mechanism. Multivoxel pattern analysis (MVPA) revealed significant decoding of PLDs and fully visible grasping observation conditions in occipital, parietal, and premotor areas belonging to eAON. Data show that kinematic features conveyed by PLDs stimuli are sufficient to elicit a complete action representation, suggesting that these features can be disentangled within the eAON from the features usually characterizing fully visible actions. PLDs stimuli could be useful in assessing which areas are recruited, when only kinematic cues are available, for action recognition, imitation, and motor learning