Experimental paradigm of therapeutic effect of magnolol on MPTP-lesioned animals.

<p>Experimental paradigm of therapeutic effect of magnolol on MPTP-lesioned animals.</p

Ex vivo ARG of ¹⁸F-FP-(+)-DTBZ in C57BL/6 mouse brain.

<p>ARG performed immediately after the third PET scan on day 17. (A) The Sham, (B) the MPTP, and (C) the MPTP + Magnolol mice. CPd: dorsal caudate putamen; CPv: ventral caudate putamen; SN: substantial nigra.</p

Quantitative analysis of the ex vivo ¹⁸F-FP-(+)-DTBZ ARG in the Sham, the MPTP, and the MPTP + Magnolol mice (n = 4 in each group).

<p>*p < 0.05 vs. the Sham group; †p < 0.05 vs. the MPTP group.</p

Immunohistochemical staining of anti-VMAT2 and anti-TH antibodies in striatal sections of the Sham, the MPTP, and the MPTP + Magnolol mice.

<p>Bar = 400 μm.</p

Striatal SUr of ¹⁸F-FP-(+)-DTBZ found by PET studies of the brains of the Sham, the MPTP, and the MPTP + Magnolol group mice (n = 4 in each group).

<p>Striatal SUr of ¹⁸F-FP-(+)-DTBZ found by PET studies of the brains of the Sham, the MPTP, and the MPTP + Magnolol group mice (n = 4 in each group).</p

Scatter plot and linear regression analysis between ex vivo ARG data and quantitative striatal ¹⁸F-FP-(+)-DTBZ SUr data obtained using PET imaging.

<p>Scatter plot and linear regression analysis between ex vivo ARG data and quantitative striatal ¹⁸F-FP-(+)-DTBZ SUr data obtained using PET imaging.</p