Association analysis between <i>HIF2A</i> tSNPs and levels of high altitude among native Tibetans.

<p>Abbreviations: Additive, additive model; Dominant, dominant model.</p><p><i>P</i>-values except the noted ones are calculated from χ² test.</p><p>^<b>a</b><i>P</i>-values are calculated from Fisher exact test.</p><p>^<b>b</b> Bold type denotes <i>P</i><0.05.</p><p>Association analysis between <i>HIF2A</i> tSNPs and levels of high altitude among native Tibetans.</p

Clinical characteristics of the studied groups.

<p>Abbreviations: BMI, body mass index; RBC, red blood cell count, RBC; HB, hemoglobin; HCT, hematocrit; LVEF, left ventricular ejection fraction.</p><p>^<b>a</b> Data are means ± SD.</p><p>Clinical characteristics of the studied groups.</p

Correlation of allele frequencies of <i>HIF2A</i> variants in Tibetans and level of high altitude.

<p>solid circle, rs56721780-C; solid diamond, rs6756667-A; solid square, rs7589621-G; solid triangle, rs1868092-A</p

Association analysis between <i>HIF1A</i> tSNPs and levels of high altitude among native Tibetans.

<p>Abbreviations: Additive, additive model; Dominant, dominant model.</p><p><i>P</i>-values except the noted ones are calculated from χ² test.</p><p>^<b>a</b><i>P</i>-values are calculated from Fisher exact test.</p><p>^<b>b</b> Bold type denotes <i>P</i><0.05.</p><p>Association analysis between <i>HIF1A</i> tSNPs and levels of high altitude among native Tibetans.</p

Allele Frequencies of the altitude-associated <i>HIF2A</i> tSNPs between populations.

<p>Abbreviations: TBT, Tibetan in Tibet; TBQ, Tibetan in Qinghai; CHB, Chinese Han in Beijing. Japanese in Tokyo, Japan.</p><p>^<b>a</b> From 1000 GENOMES, phase 1.</p><p>^<b>b</b> From Xu <i>et al</i>.2011.</p><p>^<b>c</b> From Simonson <i>et al</i>.2010.</p><p>^<b>d</b> No data.</p><p>Allele Frequencies of the altitude-associated <i>HIF2A</i> tSNPs between populations.</p

The effect (path coefficients) of BMI, smoking drinking on composite phenotypes evaluated by PLSPM and bootstrap at significance level (<i>α = 0.05</i>).

<p>L0: blood pressure increment; L1: respiratory function increment; L2: blood cells counts increment; L3: red blood cell volume increment; L4: hemoglobin concentration increment; L5: oxygen saturation increment.</p

Demographic characteristics of individuals collected in the sample.

<p>A) The altitude distribution of subjects' native place; B) The smoking status of individuals; C) The drinking status of the individuals.</p

Physiological responses at different phases of high altitude acclimatization for individuals from different altitudes.

1<p>mean of the physiological response.</p>a<p>physiological responses performed differently at baseline phase of acclimatization (<i>α = 0.05</i>).</p>b<p>physiological responses performed differently at acute phase of acclimatization (<i>α</i> = <i>0.05</i>).</p>c<p>physiological responses performed differently at chronic phase of acclimatization (<i>α</i> = <i>0.05</i>).</p

Composite phenotypes extracted from physiological traits by PLSPM.

<p>L0: blood pressure increment; L1: respiratory function increment; L2: blood cells counts increment; L3: red blood cell volume increment; L4: hemoglobin concentration increment; L5: oxygen saturation increment.</p