1 research outputs found
Fe-Based Metal–Organic Frameworks with Ferroptosis Generation Ability for Remodeling Chemotherapy of Non-small Cell Lung Cancer
Synergistic
therapeutic nanomedicine with great biosafety was regarded
as a promising strategy for cancer therapy in clinic. Due to the drug
resistance and insufficient performance of chemotherapy, the response
rate in non-small cell lung cancer is limited. As another effective
strategy against tumor, ferroptosis may enhance the sensitivity of
chemotherapy. Herein, we reported a biomimetic iron metal–organic
framework (Fe-MOF) nanomedicine responding to the intracellular environment
of non-small cell lung cancer therapy to accelerate tumor cell death
by inducing the ferroptosis and apoptosis of tumor cells. We demonstrated
that the doxorubicin (DOX)-loaded biomimetic Fe-MOF (mFe-MOFDOX) could dramatically promote degradation for Fe2+ generation
and release of DOX in the intracellular acidic microenvironment. The
mFe-MOFDOX nanoparticles enhanced the generation of reactive
oxygen species (ROS) to induce comparable glutathione peroxidase 4
(GPX4)-mediated ferroptosis and assisted DOX-mediated apoptosis. Eventually,
the combination of biomimetic nanoparticle-induced ferroptosis and
chemotherapy-induced apoptosis inhibited tumor growth and lung metastasis,
suggesting the promising potential of ferroptosis induction for promoting
non-small cell lung cancer chemotherapy