The global healthspan extension initiative: selective approaches to validated technologies and integrated biomarkers

Recent advances in rapidly developing science and technology, especially key discoveries in biomedical research and emerging sciences have the potential to significantly improve human health quality, healthspan extension and overcome many health challenges in the world. As a result, many countries, including developing countries are increasing the resources dedicated to establishing centers of excellence and innovative technology clusters in order to be able to create global scale, competitiveness and new industries. The Nazarbayev University of Kazakhstan aims to become a globally recognized institution of teaching, research and clinical excellence so that its students are equipped to compete internationally. Academic freedom and institutional independence are legally sanctioned at Nazarbayev University, setting it apart from some other universities in Kazakhstan and Central Asia. In the past Life Sciences Center of Nazarbayev university conducted several research programs and projects related to personalized medicine and further development of proactive strategy of healthy aging. Indeed to get significant healthspan extension we need some mandatory resources to be identified: Addressed Health Challenges, Integrated Biomarkers, Validated Technologies, Regulatory Framework. It is quite clear now that targeting only pathology, metabolism is time consuming, expensive and not always efficient. Addressing the main clinically significant driving molecular pathways or category in particular pathology and targeting could be more defined and efficient approach. We are more focused on projects related to genomics research, microbiome research, stem cells, neuroscience, the system of autophagy and searching as well for biologically active substances with senolytic activity, geroprotectors. Recent publications showing many promising technologies and biomarkers in life sciences, but new technologies are needed to be validated and biomarkers to be integrated. Considering the main trend of biomedical research, innovations and emerging sciences in partnership with the UK partners we initiated the Kazakhstan Healthspan extension initiative. It will pioneer a new paradigm of health care system, innovative business model and global leading hub in terms of establishing foundations for personalized medicine, biomedical industry and other new industries as well as to create the favorable regulatory environment and incentives

Interlaboratory comparison of tooth enamel dosimetry on Semipalatinsk region : Part 1, general view.

For intercomparison of methods of dose determination using electron paramagnetic resonance (EPR) spectroscopy of tooth enamel, the same sets of enamel samples were analyzed in different laboratories using similar recording parameters. The sets of samples included calibration samples irradiated in known doses, test samples irradiated to doses unknown to the participants and accidental dose samples prepared from teeth of humans affected by radioactive fallout from nuclear tests in the Semipalatinsk Nuclear Test Site in Kazakhstan. The test samples were analyzed to determine the differences in the resulting doses using different spectrometers and different spectra processing methods. The accidental dose samples were analyzed in order to test the precision of doses determined by EPR spectroscopy and to obtain more accurate values by averaging the results from different laboratories

Interlaboratory comparison of tooth enamel dosimetry on Semipalatinsk region : Part 2, Effects of spectrum processing.

In order to investigate the effects of spectrum processing procedures on the results of dose determination using EPR spectroscopy of human tooth enamel, spectra of the same samples measured in different laboratories in the course of the intercomparison were processed by some of the participants using their own unique procedures. Spectra of samples irradiated to known doses (calibration samples) and of samples irradiated to doses unknown to the participants (test samples) were analyzed. By comparison of the results obtained using different spectrum processing methods, it is shown that the precision of calibration and the accuracy of dose determination may be improved by appropriate choice of spectrum processing procedure