Dyeing and finishing performance of different PTT/PET bi-component filament fabrics

The dyeing and finishing performance of different bi-component polytrimethylene terephthalate/polyethylene terephthalate (PTT/PET) filament fabrics along with the elasticity of end-products have been studied. Three kinds of PTT/PET side-by-side bi-component filaments have been selected as weft yarn along with the polyester filament as warp yarn. Fabrics are then woven, dyed and finished under the same conditions. The weight reduction rate, widthwise shrinkage, elastic elongation and elastic recovery percentage of the above fabrics are observed to characterize the changes involved during the process. The results indicate that as denier per filament (DPF) increases, the weight reduction rate decreases but the widthwise shrinkage increases. The weight reduction rate decreases as the weft density increases. The elastic recovery decreases as the elastic elongation increases. Optical microscope, scanning electron microscope, different scanning calorimetry examinations show that due to the finer DPF and larger specific surface area, PTT/PET filament exhibits separation of the two components, due to the caustic corrosion during dyeing and finishing, and hence the high elasticity inherent in bi-component filaments is lost

Population pharmacokinetics of FCN-159, a MEK1/2 inhibitor, in adult patients with advanced melanoma and neurofibromatosis type 1 (NF1) and model informed dosing recommendations for NF1 pediatrics

Objective: FCN-159 is a highly active mitogen-activated extracellular signal-regulated kinase 1/2 (MEK1/2) inhibitor in patients with advanced melanoma and neurofibromatosis type 1 (NF1). We report a population pharmacokinetic (PopPK) model-based analysis of FCN-159 and its application to inform dose selection for NF1 pediatric trials.Methods: PK data collected from patients with advanced melanoma and NF1 in two clinical studies (NCT03932253 and NCT04954001) were analyzed using a non-linear mixed effects model. The adult model was adapted by incorporating allometric scaling for PK projection in 2–17 years old children. Pediatric exposure in different body surface area (BSA) bins was simulated to identify nominal doses (i.e., dose amounts given as integers) and BSA bin cutoffs to achieve exposure comparable to adults’ optimal exposure across the entire pediatric BSA range.Results: The final dataset consisted of 45 subjects with a total of 1030 PK samples. The PK of FCN-159 was well-described by a 2-compartment model with first-order linear elimination and delayed first-order absorption. Covariates, including BSA, age, sex, albumin, total protein, and cancer type, were identified as statistically significant predictors of FCN-159 disposition. Simulations based on the final model projected daily doses of 4 mg/m2 QD with optimized BSA bin cutoffs would allow fixed nominal doses within each bin and result in steady state exposure approximating the adult exposure observed at the recommended phase 2 dose (RP2D) in NF1, which is 8 mg QD.Conclusion: The developed population PK model adequately described the PK profile of FCN-159, which was adapted using allometric scaling to inform dose selection for NF1 pediatric trials

Dyeing and finishing performance of different PTT/PET bi-component filament fabrics

411-417Thedyeing and finishing performance of different bi-component polytrimethylene terephthalate/polyethylene terephthalate (PTT/PET) filament fabrics along with the elasticity of end-productshave been studied. Three kinds of PTT/PET side-by-side bi-componentfilamentshave beenselected as weft yarnalong with the polyester filament as warp yarn. Fabrics arethenwoven, dyed and finished under the same conditions. The weight reduction rate, widthwise shrinkage, elastic elongationand elastic recovery percentage of the above fabrics areobservedto characterize the changes involved during the process. The results indicate that asdenier per filament(DPF) increases, the weight reduction rate decreases but the widthwise shrinkageincreases. The weight reduction rate decreases as the weft density increases. The elastic recovery decreases as the elastic elongation increases. Optical microscope, scanning electron microscope, different scanning calorimetry examinations show that due to the finer DPF and larger specific surface area, PTT/PET filament exhibits separation of the two components, due to thecaustic corrosion during dyeing and finishing,and hence the high elasticity inherent in bi-component filaments is lost

Design and Characterization of Periodically Conductive Woven Fabric

In this paper, a novel kind of electromagnetic (EM) functional textiles is proposed, which show high-pass characteristics as they interact with EM waves. The periodically conductive woven fabric was designed, fabricated, and measured. Specifically, by means of unit cell model building and EM simulation, the theoretical S21 (transmission coefficient) and S11 (reflection coefficient) curves were obtained. A concrete sample was fabricated through weaving process, and its transmission characteristics were measured in the microwave anechoic chamber. The measured and simulated results were highly consistent, demonstrating the validity of design process. Compared with the aluminum foil paper sample, the S21 values of fabricated sample were a little smaller, and the reason could be attributed to yarn crimp and surface roughness. The EM characteristics of fabricated sample under two different polarization modes were slightly different, which was due to the beating-up tension of weaving process. The work could offer new research ideas, and the related products have potential advantages over rigid plates on the account of textile characteristics

NONLINEAR SIMULATION AND EXPERIMENTAL ANALYSIS OF THE PRE-CLAMP OF THE EXTRA HIGH PRESSURE SPACER BARS

The looseness or fall off of the clamp is one of the important factors for the failure of spacer bar. The research on the clamp strength is very important. Based on ANSYS finite element analysis software,non-linear emulation analysis is carried out. A reinforced spacer clamps was chosen as the object,using Mooney-Rivlin rubber constitutive model,simulating clamp for pre-clamping the wire by using pre-rigid displacement and simulating non-uniformloading conditions such as wire icing and winding by applying the tension along the line and rotarytorque load. Compared with experiment result,it shows that the strength and gripping performance of the new clamp satisfies the requirement of DL/T1098-2009,and the clamprubber spacer plays a role in reducing wear and protection. At the same time,the correctness of finite element model of spacer bar clamp is verified. It also provides useful reference for the clamp structure improvements,and lays the foundation for wind-resistant simulation analysis of high-voltage transmission line system

Interfacial Structure of Polytrimethylene Terephthalate/Polyethylene Terephthalate Bicomponent Filament

The interfacial structure and binding forces of polytrimethylene terephthalate/polyethylene terephthalate filament were investigated through the methods of Carbon-13 nuclear magnetic resonance (13C-NMR), differential scanning calorimeter (DSC), scanning electron microscopy (SEM) and optical microscopy. When two molten polymers met during the spinning process, an interface layer between the PTT and PET components formed and played an important role in binding the two components together. When the blending time was sufficient, an ester-interchange reaction took place with the generation of the copolymer. The PET recrystallisation was observed in the DSC curve under the influence of entangled PTT molecular chains. The morphology of the cross-section and side view proved that the linear boundary line was short and weaker in binding without a chemical bond and molecular diffusion. Side-by-side bi-component fiber and split-type fiber was able to be controllably spun by adjusting the spinning parameters