Locally advanced head and neck squamous cell carcinoma treatment efficacy and safety: a systematic review and network meta-analysis

Head and neck squamous cell carcinoma (HNSCC) accounts for approximately 3% of new cancer cases and 3% of all deaths worldwide. Most HNSCC patients are locally advanced (LA) at diagnosis. The combination of radiotherapy (RT), chemotherapy, targeted therapy, and immunotherapy are the primary LA-HNSCC treatment options. Nevertheless, the choice of optimal LA-HNSCC treatment remains controversial. We systematically searched public databases for LA-HNSCC-related studies and assess treatment effectiveness and safety by assessing the objective response rate (ORR), ≥3 adverse events (AEs), overall survival (OS), progression-free survival (PFS), disease-free survival (DFS), local-region control (LRC), and disease-specific survival (DSS). 126 randomized controlled clinical trials (RCTs) were included in this study. We show that concurrent RT with nimotuzumab or conventional concurrent chemo-radiotherapy (CCRT) had significantly better efficacy and long-term survival without increasing AEs than RT alone. Accelerated fractionated radiotherapy (AFRT) showed better efficiency than conventional fractionated RT, although it had higher AEs. In addition, concurrent cetuximab combined with RT failed to show a significant advantage over RT alone.Trial registration: PROSPERO CRD42022352127

Mechanisms and applications of radiation-induced oxidative stress in regulating cancer immunotherapy

Radiotherapy (RT) is an effective treatment option for cancer patients, which induces the production of reactive oxygen species (ROS) and causes oxidative stress (OS), leading to the death of tumor cells. OS not only causes apoptosis, autophagy and ferroptosis, but also affects tumor immune response. The combination of RT and immunotherapy has revolutionized the management of various cancers. In this process, OS caused by ROS plays a critical role. Specifically, RT-induced ROS can promote the release of tumor-associated antigens (TAAs), regulate the infiltration and differentiation of immune cells, manipulate the expression of immune checkpoints, and change the tumor immune microenvironment (TME). In this review, we briefly summarize several ways in which IR induces tumor cell death and discuss the interrelationship between RT-induced OS and antitumor immunity, with a focus on the interaction of ferroptosis with immunogenic death. We also summarize the potential mechanisms by which ROS regulates immune checkpoint expression, immune cells activity, and differentiation. In addition, we conclude the therapeutic opportunity improving radiotherapy in combination with immunotherapy by regulating OS, which may be beneficial for clinical treatment

Modelling of Coplanar Interdigital Capacitor for Microwave Microfluidic Application

status: publishe

Copper homeostasis and cuproptosis in tumor pathogenesis and therapeutic strategies

Copper is an indispensable micronutrient for the development and replication of all eukaryotes, and its redox properties are both harmful and beneficial to cells. An imbalance in copper homeostasis is thought to be involved in carcinogenesis. Importantly, cancer cell proliferation, angiogenesis, and metastasis cannot be separated from the effects of copper. Cuproposis is a copper-dependent form of cell death that differs from other existing modalities of regulatory cell death. The role of cuproptosis in the pathogenesis of the nervous and cardiovascular systems has been widely studied; however, its impact on malignant tumors is yet to be fully understood from a clinical perspective. Exploring signaling pathways related to cuproptosis will undoubtedly provide a new perspective for the development of anti-tumor drugs in the future. Here, we systematically review the systemic and cellular metabolic processes of copper and the regulatory mechanisms of cuproptosis in cancer. In addition, we discuss the possibility of targeting copper ion drugs to prolong the survival of cancer patients, with an emphasis on the most representative copper ionophores and chelators. We suggest that attention should be paid to the potential value of copper in the treatment of specific cancers

Experimental Study on Local Scour and Related Mechanical Effects at River-Crossing Underwater Oil and Gas Pipelines

Among the various geological disasters that threaten the safe operation of long-distance oil and gas pipelines, water-damage disasters are numerous and widely developed. Especially the pipelines crossing river channels or gullies are vulnerable to scouring hazards from storms and floods. A water-damage disaster physical model was established to investigate the characteristics of the riverbed scour profile and the pipeline force when the pipeline was buried at different depths under the condition of different particle size riverbed sediment. Results indicated that the equilibrium scour depth changed in a spoon shape with the gradual increase of the embedment ratio in general. The equilibrium scour depth formed by the fine sand riverbed was the largest, about 1.5 times the pipeline diameter. When the pipeline was half exposed, the clay riverbed was more resistant to the scour of the river than the riverbed of fine sand and very fine pebbles with a larger particle size. In the riverbed of three particle sizes, fine sand was more difficult to withstand the scour of the river. The scour profile formed by the sand bed around the pipeline and the force and deformation of the pipeline were related to pipeline location and riverbed sediment type. Results of this study might be useful for the safety warning and protection measures of underwater pipeline crossing

A Modeling Procedure of the Broadband Dielectric Spectroscopy for Ionic Liquids

The dielectric spectroscopy (DS) measurement is an attractive noninvasive method to reveal the intrinsic information of biological materials and cell cultures. However, the presence of a double layer due to electrode polarization within the lower RF and microwave range significantly affects the accurate analysis of dielectric properties of ionic liquids. In this paper, we measure the broadband DS of five saline solutions with a microfluidic coplanar waveguide (CPW) transmission line sensor across the frequency range from 40 kHz to 110 GHz. Derived from a parallel-plate structure that is transformed from the quasi-TEM CPW sensor through a conformal mapping technique, a broadband spectroscopy modeling method is proposed, where a Cole-Cole function or a constant phase element formula is used depending on the ionic concentrations and the measurement window. Validation analysis on the five saline solutions demonstrates the capability of the modeling method in separating relaxation properties of the bulk sample from the double-layer effects.status: accepte

Integration of Interdigitated Electrodes in Split-Ring Resonator for Detecting Liquid Mixtures

status: publishe

Broadband Dielectric Spectroscopy of Cell Cultures

© 2018 IEEE. Broadband dielectric spectroscopy measurements of biological materials within RF/microwave range can reveal cellular information, which is of important value in biological and medical researches. Here, we present a platform that combines a miniaturized coplanar waveguide (CPW) transmission line (TL) sensor and a special CPW-fed interdigitated capacitor (IDC), which allows us to measure the complex permittivity of cell cultures from 300 kHz to 50 GHz. The CPW-TL and CPW-IDC sensors are integrated with an SU-8 microfluidic channel, enabling measurements of microliter or even nanoliter volumes of liquids and suspensions. Due to the accurate alignment of the SU-8 polymer and the reliable liftoff fabrication procedure, we are able to minimize the measurement errors caused by the sensors' dimension tolerance. To ensure accurate complex permittivity extraction of the tested material, related calibrations and deembedding processes are explained. With the measurement of deionized water as a validation, the platform is used to measure the complex permittivity of both a yeast cell culture and a mammalian cell culture. We elaborate on the interesting findings and discuss future possibilities.status: accepte

A Simplified Dielectric Material Characterization Algorithm for Both Liquids and Solids

IEEE A simplified dielectric material characterization technique that combines an equivalent impedance algorithm and a general “line–line” trace method is introduced. The technique is applicable to every type of transmission lines. Due to the convenient fabrication and the allowance of integration with various polymers, coplanar waveguide transmission lines integrated with an SU-8 microfluidic channel is primarily used in this study. The conformal mapping method, an efficient and straightforward way, is introduced to build the foundation of dielectric material characterization and to optimize the sensor design. A validation measurement of the proposed technique is performed on deionized water, and show valuable consistency with previous reliable data presented in the literature. Next, the technique is applied on solid SU-8 characterization with four groups of on-wafer measurements. SU-8 measurement results and the related uncertainty analysis are demonstrated subsequently.status: publishe