Angularly uniform white light-emitting diodes using an integrated reflector cup

We report on white light-emitting diodes (LEDs) with a truncated-conical (TC) geometry produced by laser micromachining. A blue LED was shaped into a circular disc with 50°-inclined sidewall using a modified laser micromachining setup. A layer of Al was coated onto the inclined sidewall and the bottom surface to form an integrated reflector. Due to the highly reflective mirror, laterally propagating photons are redirected into the upward direction, contributing to an increase of 21.7% of light intensity in the normal direction. With quantum dots applied to the surface, white light emission from this TC-LED structure demonstrated a 37% enhancement in color uniformity, compared with a conventional device. © 2010 IEEE.published_or_final_versio

Frequency-Reconfigurable Antenna using Metasurface

A frequency-reconfigurable antenna designed using metasurface (MS) to operate at around 5 GHz is proposed and studied. The frequency-reconfigurable metasurfaced (FRMS) antenna is composed of a simple circular patch antenna and a circular MS with the same diameter of 40 mm (0.67 λ) and implemented using planar technology. The MS is placed directly atop the patch antenna, making the FRMS antenna very compact and low profile with a thickness of only 3.048 mm (0.05 λ). The MS consists of rectangular-loop unit cells placed periodically in the vertical and horizontal directions. Simulation results show that the operating frequency of the antenna can be tuned by physically rotating the MS around the center with respect to the patch antenna. The MS placed atop the patch antenna behaves like a dielectric substrate and rotating the MS changes the equivalent relative permittivity of the substrate and hence the operating frequency of the FRMS antenna. Measured results show that the antenna has a tuning range from 4.76 to 5.51 GHz, a fractional tuning range of 14.6%, radiation efficiency and a realized peak gain of more than 80% and 5 dBi, respectively, across the tuning range. © 2013 IEEE.published_or_final_versio

High tunability in compositionally graded epitaxial barium strontium titanate thin films by pulsed-laser deposition

2002-2003 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Simple and efficient methods for isolation and activity measurement of the recombinant hirudin variant 3 from Bacillus subtilis

A simple purification approach of the recombinant hirudin variant 3 from the Bacillus subtilis was established, by which the hirudin could be purified to the purity of 95% through one-step chromatography with the total recovery rate of 83.9%. A modified Markwardt thrombin titration method for measuring hirudin activity was also set up. Briefly, a series of concentrations of thrombin was prepared and titrated to hirudin sample, respectively and the anti-thrombin activity-range of hirudin was narrowed down by several thrombin solutions at high or low concentration and the optimum group of thrombin concentrations was determined for titration of the hirudin sample. In this modified method, the hirudin activity was determined more accurately, concisely and promptly than the classic Markwardt method.Key words: Hirudin, thrombin titration method, chromatography, purification

Multi-type sensor placement and data fusion for structural monitoring: numerical simulation

Author name used in this publication: S. ZhuVersion of RecordPublishe

Photoluminescence and lasing characteristics of single nonpolar GaN microwires

published_or_final_versio

Increased expression of cyclooxygenase-2 in first-degree relatives of gastric cancer patients

Aim: To study the expression of cyclooxygenase-2 (COX-2) in human gastric cancer tissues and their paired adjacent mucosa, as well as mucosa from gastric antrum and corpus of the first-degree relatives of the recruited cancer patients. Methods: The expression of COX-2 mRNA in 38 patients with gastric cancer and their 29 first-degree relatives and 18 healthy controls was assessed by the real time RT-PCR. The expression of COX-2 protein was determined by Western blot. Results: A marked increase in COX-2 mRNA expression was found in 20 of 37 (54%) cancerous tissues compared to their respective paired normal mucosa (P<0.001). Interestingly, increased COX-2 mRNA expression was also found in mucosa of the corpus (6/29) and antrum (13/29) of their first-degree relatives. Increased COX-2 mRNA expression was more frequently observed in the antrum biopsies from cancer patients than in the antrum biopsies from healthy controls (P<0.05). In addition, 3 of 23 (13%) patients with atrophic mucosa and 6 of 35 (17%) patients with intestinal metaplasia showed increased COX-2 mRNA expression. Furthermore, COX-2 expression increased in H pylori-positive tissues, especially in antrum mucosa. Conclusion: Increased COX-2 expression is involved in gastric carcinogenesis, and may be necessary for maintenance of the malignant phenotype and contribute to Helicobacter pylori-associated malignant transformation. © 2005 The WJG Press and Elsevier Inc. All rights reserved.published_or_final_versio

Exploring neurotransmitters and their receptors for breast cancer prevention and treatment

While psychological factors have long been linked to breast cancer pathogenesis and outcomes, accumulating evidence is revealing how the nervous system contributes to breast cancer development, progression, and treatment resistance. Central to the psychological-neurological nexus are interactions between neurotransmitters and their receptors expressed on breast cancer cells and other types of cells in the tumor microenvironment, which activate various intracellular signaling pathways. Importantly, the manipulation of these interactions is emerging as a potential avenue for breast cancer prevention and treatment. However, an important caveat is that the same neurotransmitter can exert multiple and sometimes opposing effects. In addition, certain neurotransmitters can be produced and secreted by non-neuronal cells including breast cancer cells that similarly activate intracellular signaling upon binding to their receptors. In this review we dissect the evidence for the emerging paradigm linking neurotransmitters and their receptors with breast cancer. Foremost, we explore the intricacies of such neurotransmitter-receptor interactions, including those that impinge on other cellular components of the tumor microenvironment, such as endothelial cells and immune cells. Moreover, we discuss findings where clinical agents used to treat neurological and/or psychological disorders have exhibited preventive/therapeutic effects against breast cancer in either associative or pre-clinical studies. Further, we elaborate on the current progress to identify druggable components of the psychological-neurological nexus that can be exploited for the prevention and treatment of breast cancer as well as other tumor types. We also provide our perspectives regarding future challenges in this field where multidisciplinary cooperation is a paramount requirement

Integrated optimal placement of displacement transducers and strain gauges for better estimation of structural response

Author name used in this manuscript: S. Zhu2010-2011 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe