Nano-structured carbide-derived carbon films and their tribology

Tsinghua Science and Technology, 10(6): pp. 699-703. Retrieved March 13, 2006 from http://nano.materials.drexel.edu/Papers/CDC_Tibology_TSINGHUA.pdf. DOI: http://dx.doi.org/10.1016/S1007-0214(05)70138-3Carbide-derived carbon (CDC) is a form of carbon produced by reacting metal carbides, such as SiC or TiC, with halogens at temperatures high enough to produce fast kinetics, but too low to permit the re-arrangement of the carbon atoms into an equilibrium graphitic structure. The structure of CDC is derivative of the original carbide structure and contains nanoscale porosity and both sp2 and sp3 bonded carbon in a variety of nanoscale structures. CDC can be produced as a thin film on hard carbides to improve their tri-bological performance. CDC coatings are distinguished by their low friction coefficients and high wear resis-tance in many important industrial environments and by their resistance to spallation and delamination. The tribology of CDC coatings on SiC surfaces is described in detail

Minicircle-oriP-IFNγ: A Novel Targeted Gene Therapeutic System for EBV Positive Human Nasopharyngeal Carcinoma

) in which the transgene expression was under the transcriptional regulation of oriP promoter.. Immunohistochemistry was used to detect the expression and the activity of the IFNγ in tumor sections. Our results demonstrated that mc-oriP vectors mediated comparable gene expression and anti-proliferative effect in the EBV-positive NPC cell line C666-1 compared to mc-CMV vectors. Furthermore, mc-oriP vectors exhibited much lower killing effects on EBV-negative cell lines compared to mc-CMV vectors. The targeted expression of mc-oriP vectors was inhibited by EBNA1-siRNA in C666-1. This selective expression was corroborated in EBV-positive and -negative tumor models. as a safe and highly effective targeted gene therapeutic system for the treatment of EBV positive NPC

Effects of residual chlorine on properties of carbide derived carbon.

Effects of residual chlorine on properties of carbide derived carbon

Nano-structured carbide-derived carbon films and their tribology

Das US-Holocaust-Museum in Washington hat eine neue Online-Datenbank in Betrieb genommen, die den Zugang zu den Dokumenten seines Archivs erleichtern soll. Die Internetseite http://WorldMemoryProject.org solle den Zugang zu Informationen über jüdische und nicht-jüdische Opfer des Holocaust verbessern, teilte das Museum mit. Das Archiv des Museums umfasst demnach Dokumente zu 17 Millionen Menschen, die von den Nationalsozialisten verfolgt wurden."Das World Memory Project wird die Zugänglichkei..

Extracellular-vesicle-packaged S100A11 from osteosarcoma cells mediates lung premetastatic niche formation by recruiting gMDSCs

Summary: The premetastatic niche (PMN) contributes to lung-specific metastatic tropism in osteosarcoma. However, the crosstalk between primary tumor cells and lung stromal cells is not clearly defined. Here, we dissect the composition of immune cells in the lung PMN and identify granulocytic myeloid-derived suppressor cell (gMDSC) infiltration as positively associated with immunosuppressive PMN formation and tumor cell colonization. Osteosarcoma-cell-derived extracellular vesicles (EVs) activate lung interstitial macrophages to initiate the influx of gMDSCs via secretion of the chemokine CXCL2. Proteomic profiling of EVs reveals that EV-packaged S100A11 stimulates the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway in macrophages by interacting with USP9X. High level of S100A11 expression or circulating gMDSCs correlates with the presentation of lung metastasis and poor prognosis in osteosarcoma patients. In summary, we identify a key role of tumor-derived EVs in lung PMN formation, providing potential strategies for monitoring or preventing lung metastasis in osteosarcoma