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The Emerging Role of Ten-Eleven Translocation 1 in Epigenetic Responses to Environmental Exposures.
Mounting evidence from epidemiological studies and animal models has linked exposures to environmental factors to changes in epigenetic markers, especially in DNA methylation. These epigenetic changes may lead to dysregulation of molecular processes and functions and mediate the impact of environmental exposures in complex diseases. However, detailed molecular events that result in epigenetic changes following exposures remain unclear. Here, we review the emerging evidence supporting a critical role of ten-eleven translocation 1 (TET1) in mediating these processes. Targeting TET1 and its associated pathways may have therapeutic potential in alleviating negative impacts of environmental exposures, preventing and treating exposure-related diseases
Opinion dynamics on directed small-world networks
In this paper, we investigate the self-affirmation effect on formation of
public opinion in a directed small-world social network. The system presents a
non-equilibrium phase transition from a consensus state to a disordered state
with coexistence of opinions. The dynamical behaviors are very sensitive to the
density of long-range interactions and the strength of self-affirmation. When
the long-range interactions are sparse and individual generally does not insist
on his/her opinion, the system will display a continuous phase transition, in
the opposite case with high self-affirmation strength and dense long-range
interactions, the system does not display a phase transition. Between those two
extreme cases, the system undergoes a discontinuous phase transition.Comment: 6 pages, 5 figure
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