Neural Basis of Working Memory Enhancement after Acute Aerobic Exercise: fMRI Study of Preadolescent Children

Working memory lies at the core of cognitive function and plays a crucial role in children’s learning, reasoning, problem solving, and intellectual activity. Behavioral findings have suggested that acute aerobic exercise improves children’s working memory; however, there is still very little knowledge about whether a single session of aerobic exercise can alter working memory’s brain activation patterns, as assessed by functional magnetic resonance imaging (fMRI). Therefore, we investigated the effect of acute moderate-intensity aerobic exercise on working memory and its brain activation patterns in preadolescent children, and further explored the neural basis of acute aerobic exercise on working memory in these children. We used a within-subjects design with a counterbalanced order. Nine healthy, right-handed children were scanned with a Siemens MAGNETOM Trio 3.0 Tesla magnetic resonance imaging scanner while they performed a working memory task (N-back task), following a baseline session and a 30-min, moderate-intensity exercise session. Compared with the baseline session, acute moderate-intensity aerobic exercise benefitted performance in the N-back task, increasing brain activities of bilateral parietal cortices, left hippocampus, and the bilateral cerebellum. These data extend the current knowledge by indicating that acute aerobic exercise enhances children’s working memory, and the neural basis may be related to changes in the working memory’s brain activation patterns elicited by acute aerobic exercise

Fusion of block and keypoints based approaches for effective copy-move image forgery detection

Keypoint-based and block-based methods are two main categories of techniques for detecting copy-move forged images, one of the most common digital image forgery schemes. In general, block-based methods suffer from high computational cost due to the large number of image blocks used and fail to handle geometric transformations. On the contrary, keypoint-based approaches can overcome these two drawbacks yet are found difficult to deal with smooth regions. As a result, fusion of these two approaches is proposed for effective copy-move forgery detection. First, our scheme adaptively determines an appropriate initial size of regions to segment the image into non-overlapped regions. Feature points are extracted as keypoints using the scale invariant feature transform (SIFT) from the image. The ratio between the number of keypoints and the total number of pixels in that region is used to classify the region into smooth or non-smooth (keypoints) regions. Accordingly, block based approach using Zernike moments and keypoint based approach using SIFT along with filtering and post-processing are respectively applied to these two kinds of regions for effective forgery detection. Experimental results show that the proposed fusion scheme outperforms the keypoint-based method in reliability of detection and the block-based method in efficiency

Contralateral seventh cervical nerve transfer for central spastic arm paralysis: a systematic review and meta-analysis

ObjectivesThe specific benefits of a contralateral cervical 7 nerve transplant in people with spastic paralysis of the upper extremity caused by cerebral nerve injury are unclear. To evaluate the efficacy and safety of contralateral C7 nerve transfer for central spastic paralysis of the upper extremity, we conducted a comprehensive literature search and meta-analysis.Materials and methodsPRISMA guidelines were used to search the databases for papers comparing the efficacy of contralateral cervical 7 nerve transfer vs. rehabilitation treatment from January 2010 to August 2022. The finishing indications were expressed using SMD ± mean. A meta-analysis was used to assess the recovery of motor function in the paralyzed upper extremity.ResultsThe meta-analysis included three publications. One of the publications offers information about RCTs and non-RCTs. A total of 384 paralyzed patients were included, including 192 who underwent CC7 transfer and 192 who received rehabilitation. Results from all patients were combined and revealed that patients who had CC7 transfer may have regained greater motor function in the Fugl-Meyer score (SMD 3.52, 95% CI = 3.19–3.84, p < 0.00001) and had superior improvement in range of motion compared to the rehabilitation group (SMD 2.88, 95% CI = 2.47–3.29, p < 0.00001). In addition, the spasticity in the paralyzed upper extremity significantly improved in patients with CC7 transfer (SMD −1.42, 95% CI = −1.60 to −1.25, p < 0.00001).ConclusionOur findings suggested that a contralateral C7 nerve transfer, which has no additional adverse effects on the healthy upper limb, is a preferable method to restore motor function

Activating Transcription Factor 3 Deficiency Promotes Cardiac Hypertrophy, Dysfunction, and Fibrosis Induced by Pressure Overload

Activating transcription factor 3 (ATF3), which is encoded by an adaptive-response gene induced by various stimuli, plays an important role in the cardiovascular system. However, the effect of ATF3 on cardiac hypertrophy induced by a pathological stimulus has not been determined. Here, we investigated the effects of ATF3 deficiency on cardiac hypertrophy using in vitro and in vivo models. Aortic banding (AB) was performed to induce cardiac hypertrophy in mice. Cardiac hypertrophy was estimated by echocardiographic and hemodynamic measurements and by pathological and molecular analysis. ATF3 deficiency promoted cardiac hypertrophy, dysfunction and fibrosis after 4 weeks of AB compared to the wild type (WT) mice. Furthermore, enhanced activation of the MEK-ERK1/2 and JNK pathways was found in ATF3-knockout (KO) mice compared to WT mice. In vitro studies performed in cultured neonatal mouse cardiomyocytes confirmed that ATF3 deficiency promotes cardiomyocyte hypertrophy induced by angiotensin II, which was associated with the amplification of MEK-ERK1/2 and JNK signaling. Our results suggested that ATF3 plays a crucial role in the development of cardiac hypertrophy via negative regulation of the MEK-ERK1/2 and JNK pathways

Puerarin attenuates pressure overload-induced cardiac hypertrophy

AbstractBackgroundPuerarin is the most abundant isoflavonoid in kudzu root. It has been used to treat angina pectoris and myocardial infarction clinically. However, little is known about the effect of puerarin on cardiac hypertrophy.MethodsAortic banding (AB) was performed to induce cardiac hypertrophy in mice. Puerarin premixed in diets was administered to mice after one week of AB. Echocardiography and catheter-based measurements of hemodynamic parameters were performed at 7 weeks after starting puerarin treatment (8 weeks post-surgery). The extent of cardiac hypertrophy was also evaluated by pathological and molecular analyses of heart samples. Cardiomyocyte apoptosis was assessed by measuring Bax and Bcl-2 protein expression and terminal deoxynucleotidyl transferase dUTP nick end labeling staining. In addition, the inhibitory effect of puerarin (1μM, 5μM, 10μM, 20μM, 40μM) on mRNA expression of atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) in Ang II (1μM)-stimulated H9c2 cells was investigated using quantitative real-time reverse transcription-polymerase chain reaction.ResultsEchocardiography and catheter-based measurements of hemodynamic parameters at 7 weeks revealed the amelioration of systolic and diastolic abnormalities. Puerarin also decreased cardiac fibrosis in AB mice. Moreover, the beneficial effect of puerarin was associated with the normalization in gene expression of hypertrophic and fibrotic markers. Further studies showed that pressure overload significantly induced the activation of phosphoinositide 3-kinase (PI3K)/Akt signaling and c-Jun N-terminal kinase (JNK) signaling, which was blocked by puerarin treatment. Cardiomyocyte apoptosis and induction of Bax in response to AB were suppressed by puerarin. Furthermore, the increased mRNA expression of ANP and BNP induced by Ang II (1μM) was restrained to a different extent by different concentrations of puerarin.ConclusionPuerarin may have an ability to retard the progression of cardiac hypertrophy and apoptosis which is probably mediated by the blockade of PI3K/Akt and JNK signaling pathways

Navigating the Complexity of Describing Chinese Historical Places Using the Wikibase Platform

Chinese historical places, with their extensive history spanning thousands of years, serve as profound symbols of the nation's rich cultural legacy. Capturing their historical changes in a consistent data model for describing cultural heritage, however, poses significant challenges due to shifts in the places’ name, administrative boundaries, administrative units, and geographical locations. Various data models on platforms like Wikidata offer differing approaches: some separate place names and locations into distinct classes, while others consolidate them. This poster showcases the authors’ investigation into different data models for describing cultural heritage historical places and their chosen approach. By leveraging Wikibase as a testbed database, the authors delve into the merits and limitations of each data model, unveiling the techniques employed for bulk data creation, complexities encountered, and valuable insights derived from this exploration.</p

PTH[1-34] improves the effects of core decompression in early-stage steroid-associated osteonecrosis model by enhancing bone repair and revascularization

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Triple Flares within Five Years in ztf18aanlzzf: An Enhanced Tidal Disruption Rate in ULIRGs?

We present a noteworthy transient event in the optical light curves of ztf18aanlzzf (SDSS J161259.83+421940.3), identified as a Narrow Line Seyfert 1 (NLS1) exhibiting merging patterns in the optical image. The 16-year long-term archived light curve revealed that this target stays in a steady state, while three flares occurred within the past 5 years with time separations ranging from 1 year to 3.5 years. The flare patterns of rapid brightening and slow decline following the peak, coupled with distinctive spectral features with strong He {\sc ii} and rare appearance of Bowen fluorescence line emissions, indicate at least two Tidal Eruption Event (TDE) flares in ztf18aanlzzf with a time separation of 3.5 years. We also apply TiDE light curve modeling and yield a Black Hole (BH) mass of $\sim 10^{6}\ M_{\odot}$, which is consistent with the BH mass measured from single-epoch spectra. Besides, the observed time lags $3.90_{-2.00}^{+2.06}$ days between the g and r bands strongly disagree with the prediction of the standard accretion disk model, highlighting the intricate interaction in the inner region related to the TDE. The reoccurrence gap of these TDEs, surpassing the previously reported repeated TDEs, can be attributed to binary star tidal disruption by a binary SMBH. Notably, the frequent TDE flares observed in this ULIRG-like target align with findings in a previous report for another ULIRG, suggesting a potentially elevated TDE rate in ULIRGs. Systematic variability studies of ULIRGs may help verify whether ULIRGs indeed have higher TDE rates.Comment: 10 pages, 4 figures, submitte

Process optimization and thermodynamic property analysis of brown rice cooking quality improvement by low temperature plasma technology

In order to solve the problems of long cooking time and rough taste of brown rice, a new technology based on low temperature plasma treatment was put forward. Taking brown rice as raw material, the effects of glow intensity, treatment time and moisture content in low-temperature plasma processing on cooking time and solid loss rate of brown rice were studied, and the thermodynamic properties of white rice, brown rice and low-temperature plasma treated brown rice were analyzed by DSC. On the basis of single factor experiment, orthogonal experiment parameters of optimizing the low-temperature plasma process was glow intensity 1.8a, treatment time 2 min, moisture content 9.33%, then cooking time was about 25.31 min under this condition, solid loss rate was 19.18 mg/g. Thermodynamic analysis shows that low temperature plasma treatment can reduce the thermal phase transition temperature, termination temperature and enthalpy of brown rice. The results can be used as reference for low temperature plasma in brown rice production