Dynamic capabilities and performance improvement of private hospitals in China on the basis of resource-based theory: A case study of Foshan Chancheng Central Hospital (FCCH)

Based on the resource based view, and by applying a dynamic capabilities theory, this thesis explains and illustrates how enterprises adapt to the changing environments, identify and discover opportunities and threats. The effective coordination and integration of internal and external resources enable enterprises to form a long lasting and rapid resource model that can make enterprises to be adaptive to the changes in external environment, create more value with resources, and thus bring unique dynamic capabilities to enterprises to have sustainable competitive advantages. Dynamic capabilities can transform the old knowledge of enterprises to new knowledge or create new knowledge adapted to the new environment within the enterprise, thus changing the original capability structure of the enterprise and making the enterprise step forward. Dynamic capabilities are effective means for enterprises to obtain sustainable competitive advantage, which can only be obtained by the possession of dynamic capabilities. Taking the reform, development, strategy implementation and resource integration practice of Foshan Chancheng Hospital as an example, the research has important enlightenment significance for Chinese private hospitals to explore effective integration of internal and external resources and how to build their dynamic capabilities to improve competitive advantages and obtain good performance.Com base numa visão baseada em recursos, na teoria das capacidades dinâmicas, esta Tese pretende mostrar como as empresas se adaptam a ambientes em mudança, identificando oportunidades e ameaças no ambiente e reconstro em recursos internos e externos. A coordenação e integração eficazes de recursos internos e externos permitem que as empresas formem uma configuração de recursos rápida e duradoura que pode fazer com que as empresas se adaptem às mudanças no ambiente exter no, criem mais valor com os recursos e, assim, tragam capacidades dinâmicas exclusivas dando aso a vantagens competitivas sustentáveis. Capacidades dinâmicas podem transformar o conhecimento antigo das empresas em novo conhecimento ou criar novos conhecime ntos adaptados ao novo ambiente dentro da empresa, mudando assim a estrutura de capacidade original da empresa e fazendo a empresa dar um passo à frente. Capacidades dinâmicas são meios eficazes para as empresas obterem vantagem competitiva sustentável, qu e só pode ser obtida pela posse de capacidades dinâmicas. Tomando o desenvolvimento, a implementação da estratégia e a prática de integração de recursos do Hospital Foshan Chancheng como exemplo, a Tese discute ainda as formas fundamentais para os hospitai s privados chineses integrarem efetivamente recursos internos e externos, construindo assim capacidades dinâmicas para sustentar vantagens competitivas

Loss-of-function variants in KCTD19 cause non-obstructive azoospermia in humans

Summary: Azoospermia is a significant cause of male infertility, with non-obstructive azoospermia (NOA) being the most severe type of spermatogenic failure. NOA is mostly caused by congenital factors, but our understanding of its genetic causes is very limited. Here, we identified a frameshift variant (c.201_202insAC, p.Tyr68Thrfs∗17) and two nonsense variants (c.1897C>T, p.Gln633∗; c.2005C>T, p.Gln669∗) in KCTD19 (potassium channel tetramerization domain containing 19) from two unrelated infertile Chinese men and a consanguineous Pakistani family with three infertile brothers. Testicular histological analyses revealed meiotic metaphase I (MMI) arrest in the affected individuals. Mice modeling KCTD19 variants recapitulated the same MMI arrest phenotype due to severe disrupted individualization of MMI chromosomes. Further analysis showed a complete loss of KCTD19 protein in both Kctd19 mutant mouse testes and affected individual testes. Collectively, our findings demonstrate the pathogenicity of the identified KCTD19 variants and highlight an essential role of KCTD19 in MMI chromosome individualization