Quantifying Fluid Shear Stress in a Rocking Culture Dish

Fluid shear stress (FSS) is an important stimulus for cell functions. Compared with the well established parallel-plate and cone-and-plate systems, a rocking “see-saw” system offers some advantages such as easy operation, low cost, and high throughput. However, the FSS spatiotemporal pattern in the system has not been quantified. In the present study, we developed a lubrication-based model to analyze the FSS distributions in a rocking rectangular culture dish. We identified an important parameter (the critical flip angle) that dictates the overall FSS behaviors and suggested the right conditions to achieving temporally oscillating and spatially relatively uniform FSS. If the maximal rocking angle is kept smaller than the critical flip angle, which is defined as the angle when the fluid free surface intersects the outer edge of the dish bottom, the dish bottom remains covered with a thin layer of culture medium. The spatial variations of the peak FSS within the central 84% and 50% dish bottom are limited to 41% and 17%, respectively. The magnitude of FSS was found to be proportional to the fluid viscosity and the maximal rocking angle, and inversely proportional to the square of the fluid depth-to-length ratio and the rocking period. For a commercial rectangular dish (length of 37.6 mm) filled with ∼2 mL culture medium, the FSS at the center of the dish bottom is expected to be on the order of 0.9 dyn/cm2 when the dish is rocked +5° at 1 cycle/s. Our analysis suggests that a rocking “see-saw” system, if controlled well, can be used as an alternative method to provide low-magnitude, dynamic FSS to cultured cells

Applying Deep Learning to Answer Selection: A Study and An Open Task

We apply a general deep learning framework to address the non-factoid question answering task. Our approach does not rely on any linguistic tools and can be applied to different languages or domains. Various architectures are presented and compared. We create and release a QA corpus and setup a new QA task in the insurance domain. Experimental results demonstrate superior performance compared to the baseline methods and various technologies give further improvements. For this highly challenging task, the top-1 accuracy can reach up to 65.3% on a test set, which indicates a great potential for practical use.Comment: To appear in the proceedings of ASRU 201

SLADE: A smart large-scale task decomposer in crowdsourcing

ISSN:1041-4347ISSN:1558-219

Ultra-low threshold continuous-wave quantum dot mini-BIC lasers

Highly compact lasers with ultra-low threshold and single-mode continuous wave (CW) operation have been a long sought-after component for photonic integrated circuits (PICs). Photonic bound states in the continuum (BICs), due to their excellent ability of trapping light and enhancing light-matter interaction, have been investigated in lasing configurations combining various BIC cavities and optical gain materials. However, the realization of BIC laser with a highly compact size and an ultra-low CW threshold has remained elusive. We demonstrate room temperature CW BIC lasers in the 1310 nm O-band wavelength range, by fabricating a miniaturized BIC cavity in an InAs/GaAs epitaxial quantum dot (QD) gain membrane. By enabling effective trapping of both light and carriers in all three dimensions, ultra-low threshold of 12 {\mu}W (0.052 kW/cm^2) is achieved. Single-mode lasing is also realized in cavities as small as only 5*5 unit-cells (~2.5*2.5 {\mu}m^2 cavity size) with a mode volume of 1.16({\lambda}/n)^3. With its advantages in terms of a small footprint, ultralow power consumption, robustness of fabrication and adaptability for integration, the mini-BIC lasers offer a perspective light source for future PICs aimed at high-capacity optical communications, sensing and quantum information