Projected impacts of climate change on future invasive potential of <i>P. clarkii.</i>

<p>Models were developed with a consensus-forecast approach using the CCCMA and HADCM3 climate models under two scenarios (A2a and B2a) by 2050: blue  =  current suitable areas projected to be lost with global climate change; black  =  current suitable areas projected to be retained; and red  =  areas projected to become suitable. The predicted suitability is based on the 10th percentile training presence threshold.</p

Climate change, biogeography and shift in range size of future invasive potential of <i>P. clarkii</i>.

<p>Projected latitudinal pattern of suitability changes between the present year and 2050 for two scenarios (A2a and B2a) with global climate change (blue, current suitable areas projected to be lost; and red, the proportion of areas projected to become suitable). The predicted suitability is based on the 10th percentile training presence threshold.</p

Appendix A. Methods for estimating the benefit the Three Gorges Hydroelectric Power Plant (TGHPP) obtains from river water flow regulation.

Methods for estimating the benefit the Three Gorges Hydroelectric Power Plant (TGHPP) obtains from river water flow regulation

Description of factors included as predictor variables to model the effects of climate change on potential global distributions of the invasive <i>P. clarkii</i>.

<p>Description of factors included as predictor variables to model the effects of climate change on potential global distributions of the invasive <i>P. clarkii</i>.</p

Worldwide projection for the present invasive potential of <i>P. clarkii</i>.

<p>The native distribution (blue shading) of <i>P. clarkii</i> and its occurrence is according to ISSG and published references (see Supporting Information Text S1). Black: non-native populations; blue: native populations.</p

Collagen–Hyaluronic Acid Composite Hydrogels with Applications for Chronic Diabetic Wound Repair

Chronic diabetic wounds have become a major healthcare challenge worldwide. Improper treatment may lead to serious complications. Current treatment methods including biological and physical methods and skin grafting have limitations and disadvantages, such as poor efficacy, inconvenience of use, and high cost. Therefore, developing a more effective and feasible treatment is of great significance for the repair of chronic diabetic wounds. Hydrogels can be designed to serve multiple functions to promote the repair of chronic diabetic wounds. Furthermore, 3D bioprinting enables hydrogel customization to fit chronic diabetic wounds, thus facilitating the healing process. This paper reports a study of 3D printing of a collagen–hyaluronic acid composite hydrogels with application for chronic diabetic wound repair. In situ printed hydrogels were developed by a macromolecular crosslinking network using methacrylated recombinant human collagen (RHCMA) and methacrylated hyaluronic acid (HAMA), both of which can respond to ultraviolet (UV) irradiation. The hydrogels were also loaded with silver nanoclusters (AgNCs) with ultra-small-size nanoparticles, which have the advantages of deep penetration ability and broad-spectrum high-efficiency antibacterial properties. The results of this study show that the developed RHCMA, HAMA, and AgNCs (RHAg) composite hydrogels present good UV responsiveness, porosity, mechanical properties, printability, and biocompatibility, all of which are beneficial to wound healing. The results of this study further show that the developed RHAg hydrogels not only effectively inhibited Staphylococcus aureus and Pseudomonas aeruginosa but also promoted the proliferation and migration of fibroblasts in vitro and tissue regeneration and collagen deposition in vivo, thus producing a desirable wound repair effect and can be used as an effective functional biomaterial to promote chronic diabetic wound repair