8,593 research outputs found
Short-Packet Downlink Transmission with Non-Orthogonal Multiple Access
This work introduces downlink non-orthogonal multiple access (NOMA) into
short-packet communications. NOMA has great potential to improve fairness and
spectral efficiency with respect to orthogonal multiple access (OMA) for
low-latency downlink transmission, thus making it attractive for the emerging
Internet of Things. We consider a two-user downlink NOMA system with finite
blocklength constraints, in which the transmission rates and power allocation
are optimized. To this end, we investigate the trade-off among the transmission
rate, decoding error probability, and the transmission latency measured in
blocklength. Then, a one-dimensional search algorithm is proposed to resolve
the challenges mainly due to the achievable rate affected by the finite
blocklength and the unguaranteed successive interference cancellation. We also
analyze the performance of OMA as a benchmark to fully demonstrate the benefit
of NOMA. Our simulation results show that NOMA significantly outperforms OMA in
terms of achieving a higher effective throughput subject to the same finite
blocklength constraint, or incurring a lower latency to achieve the same
effective throughput target. Interestingly, we further find that with the
finite blocklength, the advantage of NOMA relative to OMA is more prominent
when the effective throughput targets at the two users become more comparable.Comment: 15 pages, 9 figures. This is a longer version of a paper to appear in
IEEE Transactions on Wireless Communications. Citation Information: X. Sun,
S. Yan, N. Yang, Z. Ding, C. Shen, and Z. Zhong, "Short-Packet Downlink
Transmission with Non-Orthogonal Multiple Access," IEEE Trans. Wireless
Commun., accepted to appear [Online]
https://ieeexplore.ieee.org/document/8345745
Echinacoside attenuates lipopolysaccharide-induced acute lung injury in newborn mice via inactivation of NF- ÎşB/NLRP3 signaling pathway
Purpose: To investigate the effect of echinacoside (ECH) on acute lung injury (ALI) and the underlying mechanism of action.Methods: The ALI model was established through intranasal instillation of lipopolysaccharide (LPS). Lung tissue damage was determined using hematoxylin and eosin (H&E) staining and lung wet-to-dry–weight ratio. Bronchoalveolar lavage fluid (BALF) protein concentration, cell count, and cytokine level were evaluated. Western blotting was used to determine protein expression level.Results: ECH attenuated lung tissue injury and lung wet-to-dry–weight ratio in the ALI model (p < 0.01). The total protein content and number of total cells, neutrophils, and macrophages increased in BALF of mice treated with LPS, but these increases were reversed by ECH treatment (p < 0.01). The levels of TNF-α and IL-1β increased in BALF and lung tissue of LPS-treated mice; however, ECH treatment decreased these changes (p < 0.01). In addition, ECH inhibited the activation of the nuclear factor-κB (NF-κB)/NLR family pyrin domain containing 3 (NLRP3) pathway in LPS-treated mice (p < 0.01).Conclusion: Echinacoside attenuates LPS-induced ALI via inactivation of the NF-κB/NLRP3 pathway, making echinacoside a potential drug for the treatment of ALI.
Keywords: Echinacoside, Acute lung injury, Lipopolysaccharide, Nuclear factor-ÎşB, NLR family pyrin domain containing
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