Short-Packet Downlink Transmission with Non-Orthogonal Multiple Access

This work introduces downlink non-orthogonal multiple access (NOMA) into short-packet communications. NOMA has great potential to improve fairness and spectral efficiency with respect to orthogonal multiple access (OMA) for low-latency downlink transmission, thus making it attractive for the emerging Internet of Things. We consider a two-user downlink NOMA system with finite blocklength constraints, in which the transmission rates and power allocation are optimized. To this end, we investigate the trade-off among the transmission rate, decoding error probability, and the transmission latency measured in blocklength. Then, a one-dimensional search algorithm is proposed to resolve the challenges mainly due to the achievable rate affected by the finite blocklength and the unguaranteed successive interference cancellation. We also analyze the performance of OMA as a benchmark to fully demonstrate the benefit of NOMA. Our simulation results show that NOMA significantly outperforms OMA in terms of achieving a higher effective throughput subject to the same finite blocklength constraint, or incurring a lower latency to achieve the same effective throughput target. Interestingly, we further find that with the finite blocklength, the advantage of NOMA relative to OMA is more prominent when the effective throughput targets at the two users become more comparable.Comment: 15 pages, 9 figures. This is a longer version of a paper to appear in IEEE Transactions on Wireless Communications. Citation Information: X. Sun, S. Yan, N. Yang, Z. Ding, C. Shen, and Z. Zhong, "Short-Packet Downlink Transmission with Non-Orthogonal Multiple Access," IEEE Trans. Wireless Commun., accepted to appear [Online] https://ieeexplore.ieee.org/document/8345745

Mobile 5G Network Deployment Scheme on High-Speed Railway

The fifth-generation (5G) wireless communication has experienced an upsurge of interest for empowering vertical industries, due to its high data volume, extremely low latency, high reliability, and significant improvement in user experience. Specifically, deploying 5G on high-speed railway (HSR) is critical for the promotion of smart travelling such that passengers can connect to the Internet and utilize the on-board time to continue their usual activities. However, there remains a series of challenges in practical implementation, such as the serious Doppler shift caused by the high mobility, the carriage penetration loss especially in the high-frequency bands, frequent handovers, and economic issues. To address these challenges, we propose three schemes in this article to improve the coverage of 5G networks on the train. In particular, we provide a comprehensive description of each scheme in terms of their network architecture and service establishment procedures. Specifically, the mobile edge computing (MEC) is used as the key technology to provide low-latency services for on-board passengers. Moreover, these three schemes are compared among themselves regarding the quality-of-service, the scalability of service, and the related industry development status. Finally, we discuss various potential research directions and open issues in terms of deploying 5G networks on HSR

Conformational Studies of Glucose Transporter 1 (GLUT1) as an Anticancer Drug Target

Glucose transporter 1 (GLUT1) is a facilitative glucose transporter overexpressed in various types of tumors; thus, it has been considered as an important target for cancer therapy. GLUT1 works through conformational switching from an outward-open (OOP) to an inward-open (IOP) conformation passing through an occluded conformation. It is critical to determine which conformation is preferred by bound ligands because the success of structure-based drug design depends on the appropriate starting conformation of the target protein. To find out the most favorable GLUT 1 conformation for ligand binding, we ran systemic molecular docking studies for different conformations of GLUT1 using known GLUT1 inhibitors. Our data revealed that the IOP is the preferred conformation and that residues Phe291, Phe379, Glu380, Trp388, and Trp412 may play critical roles in ligand binding to GLUT1. Our data suggests that conformational differences in these five amino acids in the different conformers of GLUT1 may be used to design ligands that inhibit GLUT1

Rhizosphere phage communities drive soil suppressiveness to bacterial wilt disease

Publisher Copyright: © 2023, The Author(s).Background: Bacterial viruses, phages, play a key role in nutrient turnover and lysis of bacteria in terrestrial ecosystems. While phages are abundant in soils, their effects on plant pathogens and rhizosphere bacterial communities are poorly understood. Here, we used metagenomics and direct experiments to causally test if differences in rhizosphere phage communities could explain variation in soil suppressiveness and bacterial wilt plant disease outcomes by plant-pathogenic Ralstonia solanacearum bacterium. Specifically, we tested two hypotheses: (1) that healthy plants are associated with stronger top-down pathogen control by R. solanacearum-specific phages (i.e. ‘primary phages’) and (2) that ‘secondary phages’ that target pathogen-inhibiting bacteria play a stronger role in diseased plant rhizosphere microbiomes by indirectly ‘helping’ the pathogen. Results: Using a repeated sampling of tomato rhizosphere soil in the field, we show that healthy plants are associated with distinct phage communities that contain relatively higher abundances of R. solanacearum-specific phages that exert strong top-down pathogen density control. Moreover, ‘secondary phages’ that targeted pathogen-inhibiting bacteria were more abundant in the diseased plant microbiomes. The roles of R. solanacearum-specific and ‘secondary phages’ were directly validated in separate greenhouse experiments where we causally show that phages can reduce soil suppressiveness, both directly and indirectly, via top-down control of pathogen densities and by alleviating interference competition between pathogen-inhibiting bacteria and the pathogen. Conclusions: Together, our findings demonstrate that soil suppressiveness, which is most often attributed to bacteria, could be driven by rhizosphere phage communities that regulate R. solanacearum densities and strength of interference competition with pathogen-suppressing bacteria. Rhizosphere phage communities are hence likely to be important in determining bacterial wilt disease outcomes and soil suppressiveness in agricultural fields. [MediaObject not available: see fulltext.].Peer reviewe

In Situ Investigation of the Silicon Carbide Particles Sintering

A real-time observation of the microstructure evolution of irregularly shaped silicon carbide powders during solid state sintering is realized by using synchrotron radiation computerized topography (SR-CT) technique. The process of sintering neck growth and material migration during sintering are clearly distinguished from 2D and 3D reconstructed images. The sintering neck size of the sample is presented for quantitative analysis of the sintering kinetics during solid state sintering. The neck size-time curve is obtained. Compared with traditional sintering theories, the neck growth exponent (7.87) obtained by SR-CT experiment is larger than that of the two-sphere model. Such condition is discussed and shown in terms of sintering neck growth, in which the sintering process slows down when the particle shape is irregular rather than spherical