Superconductivity and vortex structure on Bi2_{2}Te3_{3}/FeTe0.55_{0.55}Se0.45_{0.45} heterostructures with different thickness of Bi2_{2}Te3_{3} films

Using scanning tunnel microscopy (STM), we investigate the superconductivity and vortex properties in topological insulator Bi$_{2}$Te$_{3}$ thin films grown on the iron-based superconductor FeTe$_{0.55}$Se$_{0.45}$. The proximity-induced superconductivity weakens in the Bi$_{2}$Te$_{3}$ film when the thickness of the film increases. Unlike the elongated shape of vortex cores observed in the Bi$_{2}$Te$_{3}$ film with 2-quintuple-layer (QL) thickness, the isolated vortex cores exhibit a star shape with six rays in the 1-QL film, and the rays are along the crystalline axes of the film. This is consistent with the sixfold rotational symmetry of the film lattice, and the proximity-induced superconductivity is still topologically trivial in the 1-QL film. At a high magnetic field, when the direction between the two nearest neighbored vortices deviates from that of any crystalline axes, two cores connect each other by a pair of adjacent rays, forming a new type of electronic structure of vortex cores. On the 3-QL film, the vortex cores elongate along one of the crystalline axes of the Bi$_{2}$Te$_{3}$ film, similar to the results obtained on 2-QL films. The elongated vortex cores indicate a twofold symmetry of the superconducting gap induced by topological superconductivity with odd parity. This observation confirms possible topological superconductivity in heterostructures with a thickness of more than 2 QLs. Our results provide rich information for the vortex cores and vortex-bound states on the heterostructures consisting of the topological insulator and the iron-based superconductor.Comment: 8 pages, 8 figure

Optimization of Protein-Protein Interaction Measurements for Drug Discovery Using AFM Force Spectroscopy

Increasingly targeted in drug discovery, protein-protein interactions challenge current high throughput screening technologies in the pharmaceutical industry. Developing an effective and efficient method for screening small molecules or compounds is critical to accelerate the discovery of ligands for enzymes, receptors and other pharmaceutical targets. Here, we report developments of methods to increase the signal-to-noise ratio (SNR) for screening protein-protein interactions using atomic force microscopy (AFM) force spectroscopy. We have demonstrated the effectiveness of these developments on detecting the binding process between focal adhesion kinases (FAK) with protein kinase B (Akt1), which is a target for potential cancer drugs. These developments include optimized probe and substrate functionalization processes and redesigned probe-substrate contact regimes. Furthermore, a statistical-based data processing method was developed to enhance the contrast of the experimental data. Collectively, these results demonstrate the potential of the AFM force spectroscopy in automating drug screening with high throughput

Severe postpartum disruption of the pelvic ring: report of two cases and review of the literature

Pelvic dislocations are rare during labor, and the treatment is controversial. We report two cases of young women who sustained postpartum disruption of the pelvic ring: one case is an 8.8 cm wide separation of the pubic symphysis with sacroiliac joint disruption underwent surgical stabilization and the second case with 4.0 cm disruption being treated non-operatively. These cases illustrated of importance of accurate diagnosis, careful physical exam, fully informed consent and specific treatment for this condition

Young plasma reverses anesthesia and surgery-induced cognitive impairment in aged rats by modulating hippocampal synaptic plasticity

We investigated the protective effect of young plasma on anesthesia- and surgery-induced cognitive impairment and the potential underlying mechanism using bioinformatics, functional enrichment analysis, gene set enrichment analysis, Golgi-Cox staining, dendritic spine analysis, immunofluorescence assay, western blot analysis, and transmission electron microscopy. Furthermore, we performed behavioral assessments using the open field test, the novel object recognition test, and the Morris water maze test. We identified 1969 differentially expressed genes induced by young plasma treatment, including 800 upregulated genes and 1169 downregulated genes, highlighting several enriched biological processes (signal release from synapse, postsynaptic density and neuron to neuron synapse). Anesthesia- and surgery-induced cognitive impairment in aged rats was comparatively less severe following young plasma preinfusion. In addition, the decreased levels of synapse-related and tyrosine kinase B/extracellular signal-regulated protein kinase/cyclic adenosine monophosphate response element-binding protein (TrkB/ERK/CREB) signaling pathway-related proteins, dendritic and spine deficits, and ultrastructural changes were ameliorated in aged mice following young plasma preinfusion. Together, these findings suggest that young plasma reverses anesthesia- and surgery-induced cognitive impairment in aged rats and that the mechanism is associated with the activation of the TrkB/ERK/CREB signaling pathway and improvement in hippocampal synaptic plasticity

A Mild Dyssynchronous Contraction Pattern Detected by SPECT Myocardial Perfusion Imaging Predicts Super-Response to Cardiac Resynchronization Therapy

Background: Using single photon emission computed tomography myocardial perfusion imaging (SPECT MPI) with phase analysis (PA), we aimed to identify the predictive value of a new contraction pattern in cardiac resynchronization therapy (CRT) response. Methods: Left ventricular mechanical dyssynchrony (LVMD) was evaluated using SPECT MPI with PA in non-ischemic dilated cardiomyopathy (DCM) patients with left bundle branch block (LBBB) indicated for CRT. CRT super-response was defined as LV ejection fraction (EF) ≥50% or an absolute increase of LVEF \u3e15%. The LV contraction was categorized as the mild dyssynchronous pattern when the phase standard deviation (PSD) ≤ 40.3° and phase histogram bandwidth (PBW) ≤ 111.9°, otherwise it was defined as severe dyssynchronous pattern which was further characterized as U-shaped, heterogeneous or homogenous pattern. Results: The final cohort comprised 74 patients, including 32 (43.2%) in mild dyssynchronous group, 17 (23%) in U-shaped group, 19 (25.7%) in heterogeneous group, and 6 (8.1%) in homogenous group. The mild dyssynchronous group had lower PSD and PBW than U-shaped, heterogeneous, and homogenous groups ( \u3c 0.0001). Compared to patients with the heterogeneous pattern, the odds ratios (ORs) with 95% confidence intervals (CIs) for CRT super-response were 10.182(2.43-42.663), 12.8(2.545-64.372), and 2.667(0.327-21.773) for patients with mild dyssynchronous, U-shaped, and homogenous pattern, respectively. After multivariable adjustment, mild dyssynchronous group remained associated with increased CRT super-response (adjusted OR 5.709, 95% CI 1.152-28.293). Kaplan-Meier curves showed that mild dyssynchronous group demonstrated a better long-term prognosis. Conclusions: The mild dyssynchronous pattern in patients with DCM is associated with an increased CRT super-response and better long-term prognosis

Synthesis and properties of a novel highly thermal stable N-propargyl monomer containing benzoxazole ring

© 2017, © The Author(s) 2017. A novel highly thermal stable propargyl functional compound containing benzoxazole ring, N, N, N′, N′-tetra propargyl-5-amino-2-(p-aminophenyl) benzoxazole (TPAPB), was proposed and synthesized using a phase-transfer catalytic method. The cure behavior of TPAPB was investigated by non-isothermal differential scanning calorimetry analysis. The solubility and rheological properties of TPAPB, as well as its broad temperature window from 130°C to 200°C with low viscosity, offered excellent processability for TPAPB to be used as a potential monomer of thermosetting polymer resin. It was found that the glass transition temperature of cured TPAPB was 359°C, and the temperature of 5% weight loss was 418°C in argon with the char residue up to 70% at 700°C. The polymerized resin exhibited high heat resistance and thermal stability, together with its processability, making it good candidate as highly heat-resistant polymer matrix for advanced composite applications