106 research outputs found
EDMSound: Spectrogram Based Diffusion Models for Efficient and High-Quality Audio Synthesis
Audio diffusion models can synthesize a wide variety of sounds. Existing
models often operate on the latent domain with cascaded phase recovery modules
to reconstruct waveform. This poses challenges when generating high-fidelity
audio. In this paper, we propose EDMSound, a diffusion-based generative model
in spectrogram domain under the framework of elucidated diffusion models (EDM).
Combining with efficient deterministic sampler, we achieved similar Fr\'echet
audio distance (FAD) score as top-ranked baseline with only 10 steps and
reached state-of-the-art performance with 50 steps on the DCASE2023 foley sound
generation benchmark. We also revealed a potential concern regarding diffusion
based audio generation models that they tend to generate samples with high
perceptual similarity to the data from training data. Project page:
https://agentcooper2002.github.io/EDMSound/Comment: Accepted at NeurIPS Workshop: Machine Learning for Audio (Camera
Ready
Robot Learning on the Job: Human-in-the-Loop Autonomy and Learning During Deployment
With the rapid growth of computing powers and recent advances in deep
learning, we have witnessed impressive demonstrations of novel robot
capabilities in research settings. Nonetheless, these learning systems exhibit
brittle generalization and require excessive training data for practical tasks.
To harness the capabilities of state-of-the-art robot learning models while
embracing their imperfections, we present Sirius, a principled framework for
humans and robots to collaborate through a division of work. In this framework,
partially autonomous robots are tasked with handling a major portion of
decision-making where they work reliably; meanwhile, human operators monitor
the process and intervene in challenging situations. Such a human-robot team
ensures safe deployments in complex tasks. Further, we introduce a new learning
algorithm to improve the policy's performance on the data collected from the
task executions. The core idea is re-weighing training samples with
approximated human trust and optimizing the policies with weighted behavioral
cloning. We evaluate Sirius in simulation and on real hardware, showing that
Sirius consistently outperforms baselines over a collection of contact-rich
manipulation tasks, achieving an 8% boost in simulation and 27% on real
hardware than the state-of-the-art methods, with twice faster convergence and
85% memory size reduction. Videos and code are available at
https://ut-austin-rpl.github.io/sirius
Comparison Study Of High-performance Rule-based HVAC Control With Deep Reinforcement Learning-based Control In A Multi-zone VAV System
Effects of Chinese Medicine Tong xinluo on Diabetic Nephropathy via Inhibiting TGF- β
Diabetic nephropathy (DN) is a major cause of chronic kidney failure and characterized by interstitial and glomeruli fibrosis. Epithelial-to-mesenchymal transition (EMT) plays an important role in the pathogenesis of DN. Tong xinluo (TXL), a Chinese herbal compound, has been used in China with established therapeutic efficacy in patients with DN. To investigate the molecular mechanism of TXL improving DN, KK-Ay mice were selected as models for the evaluation of pathogenesis and treatment in DN. In vitro, TGF-β1 was used to induce EMT. Western blot (WB), immunofluorescence staining, and real-time polymerase chain reaction (RT-PCR) were applied to detect the changes of EMT markers in vivo and in vitro, respectively. Results showed the expressions of TGF-β1 and its downstream proteins smad3/p-smad3 were greatly reduced in TXL group; meantime, TXL restored the expression of smad7. As a result, the expressions of collagen IV (Col IV) and fibronectin (FN) were significantly decreased in TXL group. In vivo, 24 h-UAER (24-hour urine albumin excretion ratio) and BUN (blood urea nitrogen) were decreased and Ccr (creatinine clearance ratio) was increased in TXL group compared with DN group. In summary, the present study demonstrates that TXL successfully inhibits TGF-β1-induced epithelial-to-mesenchymal transition in DN, which may account for the therapeutic efficacy in TXL-mediated renoprotection
A critical review of cyber-physical security for building automation systems
Modern Building Automation Systems (BASs), as the brain that enables the
smartness of a smart building, often require increased connectivity both among
system components as well as with outside entities, such as optimized
automation via outsourced cloud analytics and increased building-grid
integrations. However, increased connectivity and accessibility come with
increased cyber security threats. BASs were historically developed as closed
environments with limited cyber-security considerations. As a result, BASs in
many buildings are vulnerable to cyber-attacks that may cause adverse
consequences, such as occupant discomfort, excessive energy usage, and
unexpected equipment downtime. Therefore, there is a strong need to advance the
state-of-the-art in cyber-physical security for BASs and provide practical
solutions for attack mitigation in buildings. However, an inclusive and
systematic review of BAS vulnerabilities, potential cyber-attacks with impact
assessment, detection & defense approaches, and cyber-secure resilient control
strategies is currently lacking in the literature. This review paper fills the
gap by providing a comprehensive up-to-date review of cyber-physical security
for BASs at three levels in commercial buildings: management level, automation
level, and field level. The general BASs vulnerabilities and protocol-specific
vulnerabilities for the four dominant BAS protocols are reviewed, followed by a
discussion on four attack targets and seven potential attack scenarios. The
impact of cyber-attacks on BASs is summarized as signal corruption, signal
delaying, and signal blocking. The typical cyber-attack detection and defense
approaches are identified at the three levels. Cyber-secure resilient control
strategies for BASs under attack are categorized into passive and active
resilient control schemes. Open challenges and future opportunities are finally
discussed.Comment: 38 pages, 7 figures, 6 tables, submitted to Annual Reviews in Contro
A novel method for determining the neutral axis position of the asymmetric cross section and its application in the simplified progressive collapse method for damaged ships
Ultimate strength is an important design consideration for the safety of intact or damaged ship structures. The simplified progressive collapse method is a commonly used iterative method to obtain the accurate ultimate strength of ships. Since the accuracy of the neutral axis position directly affects the accuracy of the ultimate strength, the force equilibrium criterion and the force vector equilibrium criterion are adopted to search for the height and angle of the neutral axis, especially for damaged ships. However, the search for the neutral axis position based on the two criteria requires iterative computation which decreases the calculation efficiency. In this paper, the relationship between the results of the iterative process and the neutral axis position is studied, and it is found that the relationship is approximately linear. Then a new iterative method based on the linear equation is proposed to obtain the neutral axis position and is adopted to improve the simplified progressive collapse method. Finally, the new method is used to calculate the neutral axis position of a damaged VLCC. The comparison of the ultimate strength results shows that the improved simplified progressive collapse method based on the linear equation has improved efficiency and good accuracy
Association between genetic variants and development of antibodies to infliximab: A cross-sectional study in Chinese patients with Crohn’s disease
Aims: Genetic variants increase the susceptibility to anti-drug antibodies (ADA) in response to anti-TNF therapy in chronic inflammatory diseases. However, little is known about genetic variants in Chinese populations. This study aimed to identify genetic variants contributing to the risk of the development of antibodies to infliximab (ATI) in Chinese patients with Crohn’s disease (CD).Methods: CD patients (n = 104) treated with infliximab (IFX) during the maintenance therapy were enrolled in this cross-sectional study. ATI was assessed by an in-house developed drug-tolerant ELISA method. ATI titers of 1:20 and ≥1:60 were considered a low titer and a high titer, respectively. Thirteen types of single nucleotide polymorphisms (SNPs) within 13 genes involved in the immune process, the susceptibility to chronic inflammatory diseases, cytokines and apoptosis pathways were investigated.Results: The median trough levels of infliximab (TLI) in patients with clinical remission (CR) were higher than those in patients without CR (3.80 vs. 1.50 μg/mL, p < .001). The median TLI in patients with high-titer ATI was significantly lower than that in ATI-negative patients (1.15 vs. 4.48 μg/mL, p < .001) or those with low-titer ATI (1.15 vs. 2.95 μg/mL, p = .03). The HLA-DQA1*05 rs2097432 GG and GA genotypes were more frequent in patients with ATI (GG and AG vs. AA, 27/38 = 71.05% vs. 29/66 = 43.94%, OR 2.94, 95% CI 1.19–7.30, p = .02). Patients carrying the CC and AC genotypes of rs396991 in FCGR3A were associated with a higher frequency of ATI formation (CC and AC vs. AA, 37/57 = 64.91% vs. 19/47 = 40.43%, OR 2.94, 95% CI 1.24–6.96, p = .01). According to the number of variants in rs2097432 and rs393991, patients with two variants had a higher proportion of producing ATI (two variants vs. no variant, 17/21 = 80.95% vs. 9/30 = 30.00%, OR 9.92, 95% CI 2.59–37.87, p = .001; single variant vs. no variant, 30/53 = 56.60% vs. 9/30 = 30.00%, OR 3.04, 95% CI 1.18–7.88, p = .02). No association was found between other SNPs and ATI production.Conclusion: Rs2097432 in HLA-DQA1*05 and rs396991 in FCGR3A are associated with ATI production in Chinese patients with CD. A pharmacogenomic strategy could help with the clinical management of CD
Monitoring of postoperative neutrophil-to-lymphocyte ratio, D-dimer, and CA153 in: Diagnostic value for recurrent and metastatic breast cancer
ObjectiveThis stydy aims to assess the value of monitoring of postoperative neutrophil-to-lymphocyte ratio (NLR), D-dimer, and carbohydrate antigen 153 (CA153) for diagnosis of breast cancer (BC) recurrence and metastasis.Materials/MethodsA cohort of 252 BC patients who underwent surgery at the First Affiliated Hospital of Anhui Medical University between August 2008 and August 2018 were enrolled in this retrospective study. All patients were examined during outpatient follow-ups every 3 months for 5 years postoperation and every 6 months thereafter. Recurrence or metastasis was recorded for 131 patients but not for the remaining 121. Retrospective analysis of hematological parameters and clinicopathological characteristics allowed comparison between the two groups and evaluation of these parameters for the recurrent and metastatic patients.ResultsLymph node metastasis, higher tumor node metastasis (TNM) staging, and higher histological grade correlated with BC recurrence and metastasis (p < 0.05). Statistical differences were found in absolute neutrophil count (ANC), absolute lymphocyte count (ALC), CEA, CA153, D-dimer, NLR, platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) between the recurrent and metastatic and control groups (p < 0.05). Logistic regression analysis showed that CA153, D-dimer, NLR, and TNM staging were risk factors for BC recurrence and metastasis (p < 0.05). Combined values for the NLR, D-dimer, and CA153 had good diagnostic values, giving the highest area under the curve (AUC) of 0.913. High NLR, D-dimer, and CA153 values were significantly associated with recurrence and metastasis at multiple sites, lymph node metastasis, and higher TNM staging (p < 0.05). Patients with high CA153 were more likely to have bone metastases (p < 0.05), and those with high D-dimer were prone to lung metastasis (p < 0.05). With the increasing length of the postoperative period, the possibility of liver metastases gradually decreased, while that of chest wall recurrence gradually increased (p < 0.05).ConclusionMonitoring postoperative NLR, D-dimer, and CA153 is a convenient, practical method for diagnosing BC recurrence and metastasis. These metrics have good predictive value in terms of sites of recurrence and metastasis and the likelihood of multiple metastases
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