4 research outputs found

    Organic CO Prodrugs Activated by Endogenous ROS

    No full text
    CO prodrugs with triggered release mechanisms are highly desirable for targeted delivery. Herein described are organic CO prodrugs that are activated by ROS and thus can be used to selectively deliver CO to cells with elevated ROS levels. Such CO prodrugs can serve as powerful tools for targeted delivery to disease sites with elevated ROS levels and to explore the therapeutic applications of CO

    Table S1:;Table S2. from Genomic insights into the chromosomal elongation in a family of Collembola

    No full text
    Comparison of the largest chromosome of the Yoshiicerus persimilis genome with that of other published collembolan chromosome-level genomes.;Statistics of the sequencing data used for genome assembly

    Figure S1. Genome-wide chromosomal heatmap of Yoshiicerus persimilis.;Figure S2. GO (a, b) and KEGG enrichment (c, d) for genes located in duplicated regions within ElChr in Y. persimilis and T. qinae, respectively. from Genomic insights into the chromosomal elongation in a family of Collembola

    No full text
    Collembola is a highly diverse and abundant group of soil arthropods with chromosome numbers ranging from 5 to 11. Previous karyotype studies indicated that the Tomoceridae family possesses an exceptionally long chromosome. To better understand chromosome size evolution in Collembola, we obtained a chromosome-level genome of Yoshiicerus persimilis with a size of 334.44ā€…Mb and BUSCO completeness of 97.0% (nā€‰=ā€‰1013). Both genomes of Y. persimilis and Tomocerus qinae (recently published) have an exceptionally large chromosome (ElChr greater than 100ā€…Mb), accounting for nearly one-third of the genome. Comparative genomic analyses suggest that chromosomal elongation occurred independently in two species approximately 10 million years ago, rather than in the ancestor of the Tomoceridae family. The ElChr elongation was caused by large tandem and segmental duplications, as well as transposon proliferation, with genes in these regions experiencing weaker purifying selection (higher dN/dS) than conserved regions. Moreover, inter-genomic synteny analyses indicated that chromosomal fission/fusion events played a crucial role in the evolution of chromosome numbers (ranging from 5 to 7) within Entomobryomorpha. This study provides a valuable resource for investigating the chromosome evolution of Collembola

    Click, Release, and Fluoresce: A Chemical Strategy for a Cascade Prodrug System for Codelivery of Carbon Monoxide, a Drug Payload, and a Fluorescent Reporter

    No full text
    A chemical strategy was developed wherein a single trigger sets in motion a three-reaction cascade leading to the release of more than one drug-component in sequence with the generation of a fluorescent side product for easy monitoring. As a proof of concept, codelivery of CO with the antibiotic metronidazole was demonstrated
    corecore