3 research outputs found
Displacement of Bax by BMF Mediates STARD13 3′UTR-Induced Breast Cancer Cells Apoptosis in an miRNA-Depedent Manner
The balance of pro- and antiapoptotic
gene expression programs
dominates the apoptotic progress of cancer cells. We previously demonstrated
that STARD13 3′UTR suppressed breast cancer metastasis via
inhibiting epithelial-mesenchymal transition (EMT). However, the roles
of STARD13 3′UTR in breast cancer apoptosis remain elusive.
Here, we identified that STARD13 3′UTR promoted cell apoptosis <i>in vitro</i> and <i>in vivo</i>. Mechanistically,
STARD13 3′UTR acted as a ceRNA for BMF (Bcl-2 modifying factor),
thus increasing BMF expression in an miRNA-dependent manner. Meanwhile,
STARD13 3′UTR enhanced the interaction of BMF/Bcl-2 to release
Bax (Bcl-2 associated X protein) in breast cancer cells. Finally,
we verified the ceRNA relationship between STARD13 and BMF <i>in vivo</i>. Collectively, these findings suggest that STARD13
3′UTR could act as a ceRNA for BMF to promote apoptosis and
recognize STARD13 3′UTR as a potential therapeutic target in
breast cancer cells
Recyclable Metallic Imidazolium-Based Ionic Liquid-Catalyzed Selective Mono- and Double-Hydroboration in Water
The recyclable metallic imidazolium-based ionic liquid-catalyzed
mono-hydroboration of imines, double-hydroboration of imine with aldehyde,
and double-hydroboration of aniline with glutaric dialdehyde in the
presence of HBpin in water is described for the first time. The ionic
liquid [BMIm][FeCl4] showed excellent activity, high selectivity,
and good recyclability for the catalytic imine hydroborations. This
catalytic system widely tolerated various functional rings and unsaturated
groups without additional reduction. Furthermore, the metallic ionic
liquid [BMIm][FeCl4] could be reused for more than 15 runs
in water without decay of the catalytic activity
RNA Binding Protein RNPC1 Inhibits Breast Cancer Cell Metastasis via Activating STARD13-Correlated ceRNA Network
RNA
binding proteins (RBPs) are pivotal post-transcriptional regulators.
RNPC1, an RBP, acts as a tumor suppressor through binding and regulating
the expression of target genes in cancer cells. This study disclosed
that RNPC1 expression was positively correlated with breast cancer
patients’ relapse-free and overall survival and that RNPC1
suppressed breast cancer cell metastasis. Mechanistically, RNPC1 promotes
competing endogenous RNA (ceRNA) network crosstalk among STARD13,
CDH5, HOXD10, and HOXD1 (STARD13-correlated ceRNA network), which
we previously confirmed in breast cancer cells through stabilizing
the transcripts and thus facilitating the expression of these four
genes in breast cancer cells. Furthermore, RNPC1 overexpression restrained
the promotion of STARD13, CDH5, HOXD10, and HOXD1 knockdown on cell
metastasis. Notably, RNPC1 expression was positively correlated with
CDH5, HOXD1, and HOXD10 expression in breast cancer tissues and attenuated
adriamycin resistance. Taken together, these results identified that
RNPC1 could inhibit breast cancer cell metastasis via promoting a
STARD13-correlated ceRNA network