OPLS score plot of the SLE model group, PA-treated group, JP-treated group and control group by SIMCA-P11.0 (n = 10 in each group).

<p>OPLS score plot of the SLE model group, PA-treated group, JP-treated group and control group by SIMCA-P11.0 (n = 10 in each group).</p

The MS and MS/MS parameters of the standards and their quantitative results.

<p>The MS and MS/MS parameters of the standards and their quantitative results.</p

MS (a) and MS/MS (b) information of 14-HDOHE.

<p>MS (a) and MS/MS (b) information of 14-HDOHE.</p

BPC of standards (a) and JP (b).

<p>BPC of standards (a) and JP (b).</p

Identification and trends of change for differential metabolites.

a<p>Change trend compared with control group.</p>b<p>Change trend compared with SLE model group.</p><p>The levels of differential metabolites were marked with (↓) down-regulated, (↑) up-regulated and (—) no significant change (*<i>P</i><0.05; **<i>P</i><0.01).</p

(a) Merged EIC of 14-HDOHE based on the SLE model group and control group.

<p>The relative content of 14-HDOHE significantly increased in SLE model mice. (b) Merged EIC of 14-HDOHE based on SLE model group, control group, JP-treated group, and PA-treated group.</p

(a) OPLS score plot of the SLE model group (▴) and control group (▪). (b) OPLS loading plot of the SLE model group and control group.

<p>The 12 metabolites far from the origin that contributed significantly to differentiating the clustering of the SLE model group from the control group were defined as differential metabolites.</p

The perturbed metabolic network associated with SLE.

<p>The differential metabolite levels of the SLE model group compared to the control group were marked with (⇑) upregulated and (⇓) downregulated. (*Differential metabolites which could be effectively regulated by JP).</p

The HPLC results of tubers and fibrous roots of <i>B. striata</i>.

<p>The black and red curve represent for PSP (15 µL injection) and FRP (5 µL injection) 95% ethanol extract, respectively. Peak marked was identified as the same compound both existed in PSP and FRP by UV-VIS spectrum.</p

Analysis of the constituents of the PSP and FRP by TLC method.

<p>The plate was air dried and recorded under UV light (panel A), then developed with I₂/KI under room temperature (panel B), and 5% H₂SO₄-ethanol in 110°C for five minutes (panel C) sequentially. The lane 1, 3 and 5 were loaded with the sub-fractions of spe, sch and sac from the FRP; lane 2, 4 and 6 were loaded with the sub-fractions of spe, sch and sac from the PSP. Red arrows indicated the components that are absent in the PSP.</p