Pneumonia severity in the early and late administration groups.

<p>Pneumonia severity in the early and late administration groups.</p

Clinical characteristic of the early and late administration groups.

<p>Clinical characteristic of the early and late administration groups.</p

Fabrication of Free-Standing Hierarchical Carbon Nanofiber/Graphene Oxide/Polyaniline Films for Supercapacitors

A hierarchical high-performance electrode with nanoacanthine-style polyaniline (PANI) deposited onto a carbon nanofiber/graphene oxide (CNF/GO) template was successfully prepared via an in situ polymerization process. The morphology analysis shows that introducing one-dimensional (1D) CNF could significantly decrease/inhibit the staking of laminated GO to form an open-porous CNF/GO architecture. Followed with in situ facial deposition of PANI, the as-synthesized PANI modified CNF/GO exhibits three-dimensional (3D) hierarchical layered nanoarchitecture, which favors the diffusion of the electrolyte ions into the inner region of active materials. The hierarchical free-standing electrodes were directly fabricated into sandwich structured supercapacitors using 1 M H₂SO₄ as the electrolyte showing a significant specific capacitance of 450.2 F/g at the voltage scan rate of 10 mV/s. The electrochemical properties of the hierarchical structure can be further improved by a reduction procedure of GO before the deposition of PANI

Independent prognostic biomarker FERMT3 associated with immune infiltration and immunotherapy response in glioma

Adult glioma progresses rapidly and has a poor clinical outcome. The focal adhesion protein Kindlin-3 (encoded by the FERMT3 gene) participates in tumor development, drug resistance, and progression. However, the relationship between Kindlin-3 and glioma prognosis or immune microenvironment is poorly understood. We comprehensively analyzed the expression, prognostic value, mutation landscape, functional enrichment, immune infiltration, and therapeutic role of FERMT3 in glioma using multiple datasets and validated Kindlin-3 expression in clinical tissue specimens by immunohistochemistry and multiple immunofluorescence staining. FERMT3 is an independent predictor of glioma prognosis and is highly expressed in glioblastoma tissues. Functional enrichment analyses indicated that FERMT3 participates in multiple immune-related pathways such as immune response and cytokine production. Furthermore, FERMT3 expression was positively correlated with the infiltration of several immune cells, immune scores, and the expression of genes related to immune checkpoints. Further analyses revealed that overexpression of FERMT3 was linked to a better response to anti-PD1 therapy. Data from single-cell RNA-seq reveal that FERMT3 was largely expressed in microglial cells and tissue-resident macrophages. Multiple immunofluorescence staining confirmed the overexpression of Kindlin-3 in the glioma-associated microglia/macrophages (GAMs). The findings of this study provide a new perspective on the role of Kindlin-3 in glioma and may have a significant impact on the discovery of novel biomarkers and targeting of GAMs in the future.</p

CO₂‑Induced Phase Engineering: Protocol for Enhanced Photoelectrocatalytic Performance of 2D MoS₂ Nanosheets

Molybdenum disulfide (MoS₂) is a promising non-precious-metal catalyst, but its performance is limited by the density of active sites and poor electrical transport. Its metallic 1T phase possesses higher photoelectrocatalytic activity. Thus, how to efficiently increase the concentration of the 1T phase in the exfoliated two-dimensiaonal (2D) MoS₂ nanosheets is an important premise. In this work, we propose a strategy to prepare a 2D heterostructure of MoS₂ nanosheets using supercritical CO₂-induced phase engineering to form metallic 1T-MoS₂. Theoretical calculations and experimental results demonstrate that the introduced CO₂ in the 2H-MoS₂ host can prompt the transformation of partial 2H-MoS₂ lattices into 1T-MoS₂. Moreover, the electrical coupling and synergistic effect between 2H and 1T phases can greatly facilitate the efficient electron transfer from the active sites of MoS₂, which significantly improves the photocatalytic performance

Effect of chlorogenic acid supplementation on physical characteristics and other parameters in plasma, whole blood, liver and muscle in <i>db/db</i> and <i>db/m</i> mice.^*

<p>^a,b,c,d Those means not sharing a common letter in the same row are significantly different between groups (n = 8) (P <0.05).</p><p>*The values are expressed as the means±SD.</p><p>Effect of chlorogenic acid supplementation on physical characteristics and other parameters in plasma, whole blood, liver and muscle in <i>db/db</i> and <i>db/m</i> mice.^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0120842#t001fn002" target="_blank">*</a>}</p

The Clinical Characteristics and Predictors of Refractory <i>Mycoplasma pneumoniae</i> Pneumonia in Children

<div><p>Objective</p><p>To analyze the clinical characteristics of refracory <i>Mycoplasma pneumoniae</i> pneumonia (RMPP), and explore the related factors predicting RMPP.</p><p>Methods</p><p>Retrospective analysis was performed on 634 children with <i>Mycoplasma pneumoniae</i> pneumonia (MPP) hospitalized in our hospital between January 1, 2011 and December 31, 2014. The clinical features, laboratory data, radiological findings between the RMPP group and the general <i>Mycoplasma pneumoniae</i> pneumonia (GMPP) group were compared and the predictive values of related factors were analyzed.</p><p>Results</p><p>The median age of the RMPP patients (n = 145) was much older than that of the GMPP patients (n = 489) (P<0.01). We also found more severe presentations, higher incidence of extra-pulmonary complications and more serious radiological findings in RMPP group, which needed oxygen more often, longer antibiotics administration and intensive care (P<0.05). Meanwhile, the levels of C-reactive protein (CRP), lactic dehydrogenase (LDH), immunoglobulin A (IgM), interleukin (IL)-6, IL-10, interferon gamma (IFN-γ) and the percentage of neutrophils, CD8+ in RMPP group were significantly higher than those in GMPP group (P<0.05); while the levels of prealbumin (PAB) were lower than that in GMPP group (P<0.01). In ROC curve analysis, the percentage of neutrophil, CRP, LDH, PAB, IL-6, IL-10 and IFN-γ were useful for differentiating patients with RMPP from those with GMPP. Multiple logistic regression analysis showed that the CRP≥16.5mg/L, LDH ≥417IU/L and IL-6 ≥14.75pg/ml were significant predictors regarding to RMPP.</p><p>Conclusions</p><p>CRP≥16.5mg/L, LDH ≥417IU/L and IL-6 ≥14.75pg/ml might be the significant predictors of RMPP in children, which can aid in early recognition of RMPP.</p></div

Effect of CGA on the Protein Expression of ADPNR-1 (a), pAMPK (b), PPAR-α (c), and GLUT-4 (d) in the Muscle of <i>db/db</i> Mice.

<p>*P <0.05 compared with the <i>db/db</i>-CON group.</p

Clinical characteristic of GMPP and RMPP patients.

<p>Clinical characteristic of GMPP and RMPP patients.</p

Predictive values of the independent correlation factors in patients with RMPP.

<p>Predictive values of the independent correlation factors in patients with RMPP.</p