Complexes of 1-alkyl-4-aza-1-azoniabicyclo[2.2.2]octane bromides with lanthanum nitrate. Micelle-forming and adsorption properties

© 2017, Pleiades Publishing, Ltd. Novel organometallic surfactants were synthesized from monoquaternized 1,4-diazabicyclo[2.2.2]-octanes of varied hydrophobicity [Alk = C n H 2n+1 , n = 14, 18] and lanthanum nitrates. The spectral, micelleforming, and adsorption properties of the synthesized compounds were studied by IR, 1 Н NMR and electronic spectroscopy, tensiometry, conductometry, and potentiometry. The critical micelle concentrations, counterionic micellar binding constants, and adsorption parameters at the water–air interface were determined and compared with the respective characteristics of the ligands and conventional amphiphiles

Metallomicellar Systems Based on the Complexes of 1-Hexadecyl-4-aza-1-azoniabicyclo[2.2.2]octane Bromide with Transition Metal Nitrates

© 2018, Pleiades Publishing, Ltd. Potentiometry, fluorimetry, dynamic light scattering, and transmission electron microscopy were used to study the aggregation properties of the complexes 1-hexadecyl-4-aza-1-azoniabicyclo[2.2.2]octane bromide with transition metal nitrates [Cu(II), Ni(II), Co(II), and La(III)]. The critical micelle concentrations, aggregation numbers, the degree of counterion binding to micelles, the size of aggregates, and electrokinetic potentials were determined. The complexes exhibited a high antimicrobial activity, and some of them proved to be more potent than the reference drugs

Role of targeted therapy in the treatment of HER-2-positive breast cancer brain metastases

Brain metastases are detectable in 25–35 % of patients with progressive HER-2-positve breast cancer. Even after spreading metastases into the brain, chemotherapy in combination with anti-HER- 2 therapy improves survival due to better control of the systemic disease. The paper presents the results of investigations substantiating the use of anti-HER-2 targeting agents, as well as the innovative agent T-DM1 to treat brain metastases

Complexes of 1-alkyl-4-aza-1-azoniabicyclo[2.2.2]octane bromides with lanthanum nitrate. Micelle-forming and adsorption properties

© 2017, Pleiades Publishing, Ltd. Novel organometallic surfactants were synthesized from monoquaternized 1,4-diazabicyclo[2.2.2]-octanes of varied hydrophobicity [Alk = C n H 2n+1 , n = 14, 18] and lanthanum nitrates. The spectral, micelleforming, and adsorption properties of the synthesized compounds were studied by IR, 1 Н NMR and electronic spectroscopy, tensiometry, conductometry, and potentiometry. The critical micelle concentrations, counterionic micellar binding constants, and adsorption parameters at the water–air interface were determined and compared with the respective characteristics of the ligands and conventional amphiphiles

Complexes of 1-alkyl-4-aza-1-azoniabicyclo[2.2.2]octane bromides with lanthanum nitrate. Micelle-forming and adsorption properties

© 2017, Pleiades Publishing, Ltd. Novel organometallic surfactants were synthesized from monoquaternized 1,4-diazabicyclo[2.2.2]-octanes of varied hydrophobicity [Alk = C n H 2n+1 , n = 14, 18] and lanthanum nitrates. The spectral, micelleforming, and adsorption properties of the synthesized compounds were studied by IR, 1 Н NMR and electronic spectroscopy, tensiometry, conductometry, and potentiometry. The critical micelle concentrations, counterionic micellar binding constants, and adsorption parameters at the water–air interface were determined and compared with the respective characteristics of the ligands and conventional amphiphiles

Metallomicellar Systems Based on the Complexes of 1-Hexadecyl-4-aza-1-azoniabicyclo[2.2.2]octane Bromide with Transition Metal Nitrates

© 2018, Pleiades Publishing, Ltd. Potentiometry, fluorimetry, dynamic light scattering, and transmission electron microscopy were used to study the aggregation properties of the complexes 1-hexadecyl-4-aza-1-azoniabicyclo[2.2.2]octane bromide with transition metal nitrates [Cu(II), Ni(II), Co(II), and La(III)]. The critical micelle concentrations, aggregation numbers, the degree of counterion binding to micelles, the size of aggregates, and electrokinetic potentials were determined. The complexes exhibited a high antimicrobial activity, and some of them proved to be more potent than the reference drugs