5 research outputs found
Hollow MnCo<sub>2</sub>O<sub>4</sub> Submicrospheres with Multilevel Interiors: From Mesoporous Spheres to Yolk-in-Double-Shell Structures
We present a general strategy to
synthesize uniform MnCo<sub>2</sub>O<sub>4</sub> submicrospheres with
various hollow structures. By using MnCo-glycolate submicrospheres
as the precursor with proper manipulation of ramping rates during
the heating process, we have fabricated hollow MnCo<sub>2</sub>O<sub>4</sub> submicrospheres with multilevel interiors, including mesoporous
spheres, hollow spheres, yolk–shell spheres, shell-in-shell
spheres, and yolk-in-double-shell spheres. Interestingly, when tested
as anode materials in lithium ion batteries, the MnCo<sub>2</sub>O<sub>4</sub> submicrospheres with a yolk–shell structure showed
the best performance among these multilevel interior structures because
these structures can not only supply a high contact area but also
maintain a stable structure
Chelation of the Optimal Antifungal Pogostone Analogue with Copper(II) to Explore the Dual Antifungal and Antibacterial Agent
In
an ongoing effort to explore more potent antifungal pogostone
(Po) analogues, we maintained the previously identified 3-acetyl-4-hydroxy-2-pyrone
core motif while synthesizing a series of Po analogues with variations
in the alkyl side chain. The in vitro bioassay results
revealed that compound 21 was the most potent antifungal
analogue with an EC50 value of 1.1 μg/mL against Sclerotinia sclerotiorum (Lib.) de Bary. Meanwhile,
its Cu(II) complex 34 manifested significantly enhanced
antibacterial activity against Xanthomonas campestris
pv campestris (Xcc) with a minimum
inhibitory concentration (MIC) value of 300 μg/mL compared with 21 (MIC = 700 μg/mL). Complex 34 exhibited
a striking preventive effect against S. sclerotiorum and Xcc in rape leaves, with control efficacies
of 98.8% (50 μg/mL) and 80.7% (1000 μg/mL), respectively.
The 3D-QSAR models generated using Topomer comparative molecular field
analysis indicated that a shorter alkyl chain (carbon atom number
<8), terminal rings, or electron-deficient groups on the alkyl
side chain are beneficial for antifungal potency. Further, bioassay
results revealed that the component of 21 in complex 34 dominated the antifungal activity, but the introduction
of Cu(II) significantly enhanced its antibacterial activity. The toxicological
observations demonstrated that 21 could induce abnormal
mitochondrial morphology, loss of mitochondrial membrane potential,
and reactive oxygen species (ROS) accumulation in S.
sclerotiorum. The enzyme assay results showed that 21 is a moderate promiscuous inhibitor of mitochondrial complexes
II and III. Besides, the introduction of Cu(II) to 34 could promote the disruption of the cell membrane and intracellular
proteins and the ROS level in Xcc compared with 21. In summary, these results highlight the potential of 34 as a dual antifungal and antibacterial biocide for controlling
rape diseases or as a promising candidate for further optimization
Chelation of the Optimal Antifungal Pogostone Analogue with Copper(II) to Explore the Dual Antifungal and Antibacterial Agent
In
an ongoing effort to explore more potent antifungal pogostone
(Po) analogues, we maintained the previously identified 3-acetyl-4-hydroxy-2-pyrone
core motif while synthesizing a series of Po analogues with variations
in the alkyl side chain. The in vitro bioassay results
revealed that compound 21 was the most potent antifungal
analogue with an EC50 value of 1.1 μg/mL against Sclerotinia sclerotiorum (Lib.) de Bary. Meanwhile,
its Cu(II) complex 34 manifested significantly enhanced
antibacterial activity against Xanthomonas campestris
pv campestris (Xcc) with a minimum
inhibitory concentration (MIC) value of 300 μg/mL compared with 21 (MIC = 700 μg/mL). Complex 34 exhibited
a striking preventive effect against S. sclerotiorum and Xcc in rape leaves, with control efficacies
of 98.8% (50 μg/mL) and 80.7% (1000 μg/mL), respectively.
The 3D-QSAR models generated using Topomer comparative molecular field
analysis indicated that a shorter alkyl chain (carbon atom number
<8), terminal rings, or electron-deficient groups on the alkyl
side chain are beneficial for antifungal potency. Further, bioassay
results revealed that the component of 21 in complex 34 dominated the antifungal activity, but the introduction
of Cu(II) significantly enhanced its antibacterial activity. The toxicological
observations demonstrated that 21 could induce abnormal
mitochondrial morphology, loss of mitochondrial membrane potential,
and reactive oxygen species (ROS) accumulation in S.
sclerotiorum. The enzyme assay results showed that 21 is a moderate promiscuous inhibitor of mitochondrial complexes
II and III. Besides, the introduction of Cu(II) to 34 could promote the disruption of the cell membrane and intracellular
proteins and the ROS level in Xcc compared with 21. In summary, these results highlight the potential of 34 as a dual antifungal and antibacterial biocide for controlling
rape diseases or as a promising candidate for further optimization
Chelation of the Optimal Antifungal Pogostone Analogue with Copper(II) to Explore the Dual Antifungal and Antibacterial Agent
In
an ongoing effort to explore more potent antifungal pogostone
(Po) analogues, we maintained the previously identified 3-acetyl-4-hydroxy-2-pyrone
core motif while synthesizing a series of Po analogues with variations
in the alkyl side chain. The in vitro bioassay results
revealed that compound 21 was the most potent antifungal
analogue with an EC50 value of 1.1 μg/mL against Sclerotinia sclerotiorum (Lib.) de Bary. Meanwhile,
its Cu(II) complex 34 manifested significantly enhanced
antibacterial activity against Xanthomonas campestris
pv campestris (Xcc) with a minimum
inhibitory concentration (MIC) value of 300 μg/mL compared with 21 (MIC = 700 μg/mL). Complex 34 exhibited
a striking preventive effect against S. sclerotiorum and Xcc in rape leaves, with control efficacies
of 98.8% (50 μg/mL) and 80.7% (1000 μg/mL), respectively.
The 3D-QSAR models generated using Topomer comparative molecular field
analysis indicated that a shorter alkyl chain (carbon atom number
<8), terminal rings, or electron-deficient groups on the alkyl
side chain are beneficial for antifungal potency. Further, bioassay
results revealed that the component of 21 in complex 34 dominated the antifungal activity, but the introduction
of Cu(II) significantly enhanced its antibacterial activity. The toxicological
observations demonstrated that 21 could induce abnormal
mitochondrial morphology, loss of mitochondrial membrane potential,
and reactive oxygen species (ROS) accumulation in S.
sclerotiorum. The enzyme assay results showed that 21 is a moderate promiscuous inhibitor of mitochondrial complexes
II and III. Besides, the introduction of Cu(II) to 34 could promote the disruption of the cell membrane and intracellular
proteins and the ROS level in Xcc compared with 21. In summary, these results highlight the potential of 34 as a dual antifungal and antibacterial biocide for controlling
rape diseases or as a promising candidate for further optimization
Vacancy Engineering for High-Efficiency Nanofluidic Osmotic Energy Generation
Two-dimensional (2D) nanofluidic membranes have shown
great promise
in harvesting osmotic energy from the salinity difference between
seawater and fresh water. However, the output power densities are
strongly hampered by insufficient membrane permselectivity. Herein,
we demonstrate that vacancy engineering is an effective strategy to
enhance the permselectivity of 2D nanofluidic membranes to achieve
high-efficiency osmotic energy generation. Phosphorus vacancies were
facilely created on NbOPO4 (NbP) nanosheets, which remarkably
enlarged their negative surface charge. As verified by both experimental
and theoretical investigations, the vacancy-introduced NbP (V-NbP)
exhibited fast transmembrane ion migration and high ionic selectivity
originating from the improved electrostatic affinity of cations. When
applied in a natural river water|seawater osmotic power generator,
the macroscopic-scale V-NbP membrane delivered a record-high power
density of 10.7 W m–2, far exceeding the commercial
benchmark of 5.0 W m–2. This work endows the remarkable
potential of vacancy engineering for 2D materials in nanofluidic energy
devices