Canadian Speaker Session 11: Canada and U.S. Approaches - Outsourcing, Offshoring, Nearshoring, Legal Aspects, Possible Conflicts, Economic Impact and Job Effects - Canadian Speaker

offshoring, nearshoring, employment--Canada, employment--United State

Interaction/association network among the six genes containing at least one core SNPs identified by analyzing WTCCC T2D data with GMDR-GPU.

<p>Beyond the six susceptibility genes identified in this work, three other genes, <i>CTNNB1</i>, <i>RUNX3</i>, and <i>CBFB</i>, were found by a literature search. Although these genes have been associated with a number of human disorders, only two closely related diseases, i.e., T2D and colorectal cancer, are shown.</p

Core SNPs associated with T2D based on G×G analysis at different orders with GMDR-GPU program.

1<p>Gene locations were retrieved from Enzembl Genome Browser.</p>2<p>Physical location of each gene determined according to NCBI build 36.</p

Additional file 2: of Predicting gene targets from integrative analyses of summary data from GWAS and eQTL studies for 28 human complex traits

Full list of acknowledgements. (DOCX 109 kb

Best interaction models and their cross-validation consistencies (CVC), testing accuracies, and permutated P values based on 10⁷ permutated samples for the identified 24 core SNPs.

<p>Note: In our GMDR-GPU analysis, age and sex were used as covariates, and BMI was not adjusted for.</p

Intrinsic polarization conversion and avoided-mode crossing in X-cut lithium niobate microrings

Compared with well-developed free space polarization converters, polarization conversion between TE and TM modes in waveguide is generally considered to be caused by shape birefringence, like curvature, morphology of waveguide cross section and scattering. Here, we reveal a hidden polarization conversion mechanism in X-cut lithium niobate microrings, that is the conversion can be implemented by birefringence of waveguides, which will also introduce an unavoidable avoided-mode crossing. In the experiment, we find that this mode crossing results in severe suppression of one sideband in local nondegenerate four-wave mixing and disrupts the cascaded four-wave mixing on this side. Simultaneously, we proposed, for the first time to our best knowledge, one two-dimensional method to simulate the eigenmodes (TE and TM) in X-cut microrings, which avoids the obstacle from large computational effort in three-dimensional anisotropic microrings simulation, and the mode crossing point. This work will provide an entirely novel approach to the design of polarization converters and simulation for monolithic photonics integrated circuits, and may be helpful to the studies of missed temporal dissipative soliton formation in X-cut lithium niobate rings

Determination of core SNPs for T2D through two-way to five-way interaction analysis using GMDR-GPU.

<p>Each SNP is represented by a red dot and each interaction by a vertical line. The red dots in the same horizontal line correspond to the same unique SNP. Different colors of vertical lines represent different interaction dimensions (green: two-way; blue: three-way; pink: four-way; yellow: five-way). All identified core SNPs are indicated with their IDs.</p

Comparison of time required for exhaustive pair-wise search in 5,000 subjects with 10³ to 10⁶ SNPs per sample among the 1- and 6-GPU, C++ CPU, and Java CPU implementations of GMDR-GPU.

*<p>Estimated from the running time of searches of smaller data sets.</p

Results of two- to five-way SNP-SNP interaction analysis of WTCCC T2D data.

<p>Results of two- to five-way SNP-SNP interaction analysis of WTCCC T2D data.</p

Working process of the GMDR-GPU program for conducting a two-dimensional interaction search on a sample consisting of four SNPs, two covariates, and a quantitative phenotype.

<p>Working process of the GMDR-GPU program for conducting a two-dimensional interaction search on a sample consisting of four SNPs, two covariates, and a quantitative phenotype.</p