2 research outputs found
Formation of Different Gold Nanocrystal Core–Resin Shell Structures through the Control of the Core Assembly and Shell Polymerization
The formation of different Au nanocrystal core–resin
shell
structures through the control of the nanocrystal assembly and shell
polymerization is investigated. 4-Mercaptophenol is employed together
with formaldehyde as the resin monomers. 4-Mercaptophenol molecules
bond to the surface of Au nanocrystals so that the resultant phenolic
resin can intimately encapsulate Au nanocrystals. The morphologies
of the obtained structures are determined by the nanocrystal assembly
and the monomer polymerization behaviors, which are controlled by
the solution pH as well as the monomer amounts. At pH = 8–9,
Au nanorods are assembled and fused together under hydrothermal conditions
in a preferential end-to-end manner. The fused structures are coated
with a layer of resin, with the thickness controlled by the supplied
amounts of the monomers. At pH = ∼10, Au nanorods are coated
with resin of controllable thicknesses and separated from each other.
The resin-coated Au nanorods are stable in both aqueous and nonaqueous
solutions. At pH = ∼12, Au nanorods are coated with a thin
layer of resin and assembled together in a side-by-side manner. A
similar assembly and resin coating behavior is also observed with
Au nanopolyhedrons. Moreover, plasmonic–fluorescent bifunctional
structures are readily produced by incorporating CdTe nanocrystals
in the resin shell that is coated on Au nanocrystals, owing to the
presence of a number of thiol groups in the resin shell
Designed construction of tween 60@2β-CD self-assembly vesicles as drug delivery carrier for cancer chemotherapy
<p>We report a simple strategy to prepare Tween 60@2β-CD self-assembly vesicles in aqueous solution as a new drug delivery carrier for cancer chemotherapy. The spherical shape of vesicles was confirmed by transmission electron microscopy (TEM) and mean particle sizes were about 33.7 nm, as measured by dynamic light scattering, micro-IR results indicated that the self-assembly vesicles was driven by hydrogen bonding. Hydrophilic doxorubicin (DOX) was successfully loaded into the self-assembly vesicles with drug loading content of 7.85% and loading efficiency of 42%. In addition, an <i>in vitro</i> cytotoxicity study and cellular uptake assays demonstrated that the DOX-loaded Tween 60@2β-CD vesicles markedly enhanced the cellular uptake and cytotoxicity of DOX toward the Hela cells. Furthermore, when used to evaluate the <i>in vivo</i> therapeutic efficacy in mice bearing the breast cell line (4T1), DOX-loaded vesicles exhibited superior inhibition of tumor growth compared with the DOX solutions.</p