Potential of Core-Collapse Supernova Neutrino Detection at JUNO

JUNO is an underground neutrino observatory under construction in Jiangmen, China. It uses 20kton liquid scintillator as target, which enables it to detect supernova burst neutrinos of a large statistics for the next galactic core-collapse supernova (CCSN) and also pre-supernova neutrinos from the nearby CCSN progenitors. All flavors of supernova burst neutrinos can be detected by JUNO via several interaction channels, including inverse beta decay, elastic scattering on electron and proton, interactions on C12 nuclei, etc. This retains the possibility for JUNO to reconstruct the energy spectra of supernova burst neutrinos of all flavors. The real time monitoring systems based on FPGA and DAQ are under development in JUNO, which allow prompt alert and trigger-less data acquisition of CCSN events. The alert performances of both monitoring systems have been thoroughly studied using simulations. Moreover, once a CCSN is tagged, the system can give fast characterizations, such as directionality and light curve

Detection of the Diffuse Supernova Neutrino Background with JUNO

As an underground multi-purpose neutrino detector with 20 kton liquid scintillator, Jiangmen Underground Neutrino Observatory (JUNO) is competitive with and complementary to the water-Cherenkov detectors on the search for the diffuse supernova neutrino background (DSNB). Typical supernova models predict 2-4 events per year within the optimal observation window in the JUNO detector. The dominant background is from the neutral-current (NC) interaction of atmospheric neutrinos with 12C nuclei, which surpasses the DSNB by more than one order of magnitude. We evaluated the systematic uncertainty of NC background from the spread of a variety of data-driven models and further developed a method to determine NC background within 15\% with {\it{in}} {\it{situ}} measurements after ten years of running. Besides, the NC-like backgrounds can be effectively suppressed by the intrinsic pulse-shape discrimination (PSD) capabilities of liquid scintillators. In this talk, I will present in detail the improvements on NC background uncertainty evaluation, PSD discriminator development, and finally, the potential of DSNB sensitivity in JUNO

Real-time Monitoring for the Next Core-Collapse Supernova in JUNO

Core-collapse supernova (CCSN) is one of the most energetic astrophysical events in the Universe. The early and prompt detection of neutrinos before (pre-SN) and during the SN burst is a unique opportunity to realize the multi-messenger observation of the CCSN events. In this work, we describe the monitoring concept and present the sensitivity of the system to the pre-SN and SN neutrinos at the Jiangmen Underground Neutrino Observatory (JUNO), which is a 20 kton liquid scintillator detector under construction in South China. The real-time monitoring system is designed with both the prompt monitors on the electronic board and online monitors at the data acquisition stage, in order to ensure both the alert speed and alert coverage of progenitor stars. By assuming a false alert rate of 1 per year, this monitoring system can be sensitive to the pre-SN neutrinos up to the distance of about 1.6 (0.9) kpc and SN neutrinos up to about 370 (360) kpc for a progenitor mass of 30$M_{\odot}$ for the case of normal (inverted) mass ordering. The pointing ability of the CCSN is evaluated by using the accumulated event anisotropy of the inverse beta decay interactions from pre-SN or SN neutrinos, which, along with the early alert, can play important roles for the followup multi-messenger observations of the next Galactic or nearby extragalactic CCSN.Comment: 24 pages, 9 figure

Dynamic response of adjacent parallel pipes to leakage and explosion of buried gas pipelines

The gas leakage of one buried natural gas pipeline laid in parallel into the air, which results in explosion, maycause the other adjacent target pipeline to fail. In order to study the dynamic response of the target pipeline, a method fordefining the methane-air mixed gas with the non-linear finite element program LS-DYNA was established, the stress anddisplacement changes of the target pipeline under the action of the explosion of hemispherical gas cloud were studied bynumerical simulation, and quantitative analysis was carried out to the six influencing factors including pipe spacing, burieddepth, the wall thickness, diameter and operating pressure of target pipe, and the radius of gas cloud. The results show that, compared with TNT equivalent method and TNO multi-energy method, this method is more accurate in simulating near-fieldexplosions of gas cloud, the maximum equivalent Mises stress of the target pipeline is about 548 MPa when the pipelineis under the action of a flammable gas cloud with a radius of 21m and then yield failure will occur to the pipeline, radialdisplacement happens to the points on the cross-section of target pipeline and the entire pipe sinks, and the parallel pipespacing, buried depth and the radius of leaked gas cloud have a significant effect on the Mises peak stress of target pipeline.Besides, the research results could provide reference for optimization of the risk prevention and control plan of pipelineduring its design and operation

Stereoselective behavior and residues of the imazalil during strawberry growth and strawberry wine production

Imazalil is a chiral fungicide widely used to protect strawberries against gray mold, which may pose threats to food safety. This study aims to investigate the stereoselective behavior of imazalil during strawberry growth and strawberry wine production. A method was proposed and validated for the extraction and quantitative analysis of imazalil residues in strawberry, strawberry pomace, and strawberry wine by using ultra-high performance liquid chromatography-tandem mass spectrometry. The method exhibited mean recoveries ranging from 86.2% to 119.7% with relative standard deviations of 0.1–11.3%. The dissipation curve of imazalil during strawberry growth followed the first-order kinetic model with a half-life ranging from 6.5 to 7.1 days. Significant enantioselectivity of imazalil was observed in strawberry grown under field conditions and strawberry wine production process, with enantiomeric fraction values ranging from 0.51 (2 h) to 0.42 (27d) and from 0.48 (0d) to 0.52 (10d), respectively. (+)-imazalil was preferentially degraded in strawberry under field conditions, while (−)-imazalil was preferentially degraded during the fermentation process. The processing factor was lower than 1 for each procedure, indicating that the wine-making process can reduce imazalil residue in strawberry. These findings may facilitate a more accurate risk assessment of imazalil and provide important guidance for the safe and efficacious use of imazalil in agriculture

N Utilization, Residual and Loss Characteristics of Spring-Topdressing (15N-urea) Pear Orchards in the Old Course of the Yellow River Area

In the old course of the Yellow River area, most orchards are over-applied with nitrogen (N) fertilizers. To improve N management in this area, a 15N tracing experiment was conducted to investigate the absorption, distribution and loss of spring-topdressing urea in pear orchards from March to August 2019. The 7-year-old Sucui 1 pear was used as the test material, and 277.5 g of ordinary urea and 15 g of 15N-urea N were evenly applied to each plant. The N absorption, distribution and utilization efficiency of different organs from the flowering stage to the post-harvest stage were analyzed, and the residual and loss of N in the soil were also discussed. The N fertilizer utilization rate increased with the advancement of the phenological period. The N fertilizer utilization rate in the full bloom period is 10.39%, which is the fastest growing period, and reached a maximum of 23.62% in the post-harvest stage. In the young fruit stage, the amount of N derived from labeled fertilizer (%Ndff) of the fruit was only 1.02%, and most of the new vegetative organs were above 1%. Residual amount in the 20–40 cm soil layer was significantly higher than that in other soil layers. Direction of N fertilizer is N fertilizer loss>soil residue>tree absorption. N loss in the fruit expansion stage and the harvest stage is higher, which are 3.76 g and 3.74 g, respectively. N utilization rate in this area is low throughout the year. There is nutrient competition between reproductive growth and vegetative growth, which can be effectively alleviated by spring top-dressing. The N loss during fruit expansion and harvesting is serious. Attention should be paid to split fertilizer application and the timely supplementation of an appropriate amount of N fertilizer to improve N use efficiency

Glucose Increases the Abundance of Phosphate Solubilizing Bacterial Community for Better Apple Seedling Growth and Phosphate Uptake

Phosphorus-solubilizing microorganisms play an important role in soil nutrient phosphorus cycling. In order to clarify the effect of glucose (C6H12O6) on soil phosphorus transformation, the effects of glucose additions on the bacterial community, soil phosphorus status, and plant phosphorus uptake in apple rhizosphere soil were investigated. A 90-day pot experiment was carried out, and the experiment was repeated three times. Glucose additions were 0, 2.5, 5, 7.5, 10, and 12.5 g glucose per kg of soil. We measured soil bacteria and phosphorus related indexes using Illumina MiSeq sequencing technology and chemical methods. The results showed that when the glucose application rate was 2.5–7.5 g·kg−1, the soil total phosphorus content decreased by 4.4–7.3%; however, the soil acid phosphatase activity increased by 0.5–1.3 times, and the microbial biomass phosphorus increased by 29.1% and 37.0%. The content of Al-P and Fe-P in the rhizosphere soil decreased by 14.4 to 32.7 mg·kg−1 and 16.04 to 28.7 mg·kg−1, respectively. The compositional difference of the bacterial community became larger, and the relative abundance of 11 bacterial phyla changed significantly, among which the most significant change was found in Proteobacteria. This study also found that the relative abundances of Bacillus, Pseudomonas, Arthrobacter, and Cuprococcus increased by 0.9%, 2.2%, 2.4%, and 0.8%, respectively. Applying 7.5 g glucose per kg of soil can significantly increase the relative abundance of phosphorus solubilizing bacteria (Bacillus, Pseudomonas, Arthrobacter et al.) in rhizosphere soil, activate Al-P and Fe-P, and improve the availability of soil phosphorus

Gas migration patterns with different borehole sizes in underground coal seams: Numerical simulations and field observations

Gas flow in a coal seam is a complex process due to the complicated coal structure and the sorption characteristics of coal to adsorbable gas (such as carbon dioxide and methane). It is essential to understand the gas migration patterns for different fields of engineering, such as CBM exploitation, underground coal mine gas drainage, and CO2 geo-sequestration. Many factors influence gas migration patterns. From the surface production wells, the in-seam patterns of gas content cannot be quantified, and it is difficult to predict the total gas production time. In order to understand the gas flow patterns during gas recovery and the gas content variations with respect to production time, a solid-fluid coupled gas migration model is proposed to illustrate the gas flow in a coal seam. Field data was collected and simulation parameters were obtained. Based on this model, different scenarios with different borehole sizes were simulated for both directional boreholes and normal parallel boreholes in coal seams. Specifically, the borehole sizes for the directional boreholes were 10 m, 15 m, and 20 m. The borehole sizes for the normal parallel boreholes were 2 m, 4 m, and 6 m. Under different gas drainage leading times, the total gas recovery and residual gas contents were quantified. In Longwall Panel 909 of the Wuhushan coal mine, one gas drainage borehole and five 4 m monitoring boreholes were drilled. After six months of monitoring, the residual gas content was obtained and compared with the simulation results. Of the total gas, 61.36% was drained out from the first 4 m borehole. In this field study, the effective drainage diameter of the drainage bore-hole was less than 8 m after six months of drainage. The gas drainage performance was tightly affected by the borehole size and the gas drainage time. It was determined that the field observa-tions were in line with the simulation results. The findings of this study can provide field data for similar conditions

Genetic association of lipids and lipid-lowering drug target genes with non-alcoholic fatty liver diseaseResearch in context

Summary: Background: Some observational studies found that dyslipidaemia is a risk factor for non-alcoholic fatty liver disease (NAFLD), and lipid-lowering drugs may lower NAFLD risk. However, it remains unclear whether dyslipidaemia is causative for NAFLD. This Mendelian randomisation (MR) study aimed to explore the causal role of lipid traits in NAFLD and evaluate the potential effect of lipid-lowering drug targets on NAFLD. Methods: Genetic variants associated with lipid traits and variants of genes encoding lipid-lowering drug targets were extracted from the Global Lipids Genetics Consortium genome-wide association study (GWAS). Summary statistics for NAFLD were obtained from two independent GWAS datasets. Lipid-lowering drug targets that reached significance were further tested using expression quantitative trait loci data in relevant tissues. Colocalisation and mediation analyses were performed to validate the robustness of the results and explore potential mediators. Findings: No significant effect of lipid traits and eight lipid-lowering drug targets on NAFLD risk was found. Genetic mimicry of lipoprotein lipase (LPL) enhancement was associated with lower NAFLD risks in two independent datasets (OR1 = 0.60 [95% CI 0.50–0.72], p1 = 2.07 × 10−8; OR2 = 0.57 [95% CI 0.39–0.82], p2 = 3.00 × 10−3). A significant MR association (OR = 0.71 [95% CI, 0.58–0.87], p = 1.20 × 10−3) and strong colocalisation association (PP.H4 = 0.85) with NAFLD were observed for LPL expression in subcutaneous adipose tissue. Fasting insulin and type 2 diabetes mediated 7.40% and 9.15%, respectively, of the total effect of LPL on NAFLD risk. Interpretation: Our findings do not support dyslipidaemia as a causal factor for NAFLD. Among nine lipid-lowering drug targets, LPL is a promising candidate drug target in NAFLD. The mechanism of action of LPL in NAFLD may be independent of its lipid-lowering effects. Funding: Capital’s Funds for Health Improvement and Research (2022-4-4037). CAMS Innovation Fund for Medical Sciences (CIFMS, grant number: 2021-I2M-C&T-A-010)

HIV Prevalence and Associated Factors among Foreign Brides from Burma in Yunnan Province, China

<div><p>Background</p><p>Many Burmese women have migrated to Yunnan Province and married local residents over the past few decades; however, limited information is available on their HIV prevalence and ability to cope with HIV. This study aims to assess the prevalence of HIV and knowledge related to AIDS, as well as to discover possible risk factors of HIV infection among foreign brides from Burma in Yunnan Province.</p><p>Methods</p><p>A cross-sectional study was taken of all Burmese cross-border wives residing in Tengchong County using standardized questionnaires. HIV and syphilis testing was conducted at the same time.</p><p>Results</p><p>Among 600 Burmese brides, the HIV prevalence was 2.17%. Those aged 21–30, those with higher education levels and those who had resided in China less than one year had higher infection rates. The AIDS awareness rate of 39.50% was very low in this population. Only 28.67% of participants had ever been involved in prevention services. The rate of condom use was low. Classification by age, education, occupation, prior HIV testing and prior use of HIV prevention services showed a statistically significant association with mean knowledge score (p<0.05). Residing in China less than one year (OR = 3.86, 95% CI = 1.09–13.70) and having casual sex in the last year (OR = 10.49, 95% CI = 1.20–91.59) were risk factors for HIV infection.</p><p>Conclusions</p><p>Burmese brides in China are not only exposed to a high risk of HIV infection, but also seriously lack response capabilities. Educational interventions and control efforts are practical approaches that need to be strengthened among this population.</p></div