Additional file 4: Table S4. of Systematic analysis of the molecular mechanism underlying atherosclerosis using a text mining approach

Potential susceptibility genes for atherosclerosis. (XLSX 12 kb

Additional file 1: Table S1. of Systematic analysis of the molecular mechanism underlying atherosclerosis using a text mining approach

A complete list of genes identified by text mining. (XLSX 148 kb

Additional file 2: Table S2. of Systematic analysis of the molecular mechanism underlying atherosclerosis using a text mining approach

Gene ontology analysis. (XLSX 37 kb

Air–Seawater Exchange of Organochlorine Pesticides along the Sediment Plume of a Large Contaminated River

Gaseous exchange fluxes of organochlorine pesticides (OCPs) across the air–water interface of the coastal East China Sea were determined in order to assess whether the contaminated plume of the Yangtze River could be an important regional source of OCPs to the atmosphere. Hexa­chloro­cyclo­hexanes (HCHs), chlordane compounds (CHLs), and dichloro­diphenyl­trichloro­ethanes (DDTs) were the most frequently detected OCPs in air and water. Air–water exchange was mainly characterized by net volatilization for all measured OCPs. The net gaseous exchange flux ranged 10–240 ng/(m²·day) for γ-HCH, 60–370 ng/(m²·day) for <i>trans</i>-CHL, 97–410 ng/(m²·day) for <i>cis</i>-CHL, and ∼0 (e.g., equilibrium) to 490 ng/(m²·day) for <i>p</i>,<i>p</i>′-DDE. We found that the plume of the large contaminated river can serve as a significant regional secondary atmospheric source of legacy contaminants released in the catchment. In particular, the sediment plume represented the relevant source of DDT compounds (especially <i>p</i>,<i>p</i>′-DDE) sustaining net degassing when clean air masses from the open ocean reached the plume area. In contrast, a mass balance showed that, for HCHs, contaminated river discharge (water and sediment) plumes were capable of sustaining volatilization throughout the year. These results demonstrate the inconsistencies in the fate of HCHs and DDTs in this large estuarine system with declining primary sources

Key Role of the Carboxyl Terminus of Hyaluronan Synthase in Processive Synthesis and Size Control of Hyaluronic Acid Polymers

The essential pathophysiological roles of hyaluronic acid (HA) strongly depend on HA binding and HA size. Here we deployed the atomic vision of molecular dynamics (MD) simulation to experimentally investigate the influence of C-terminal mutations of Streptococcus equisimilis hyaluronan synthase (SeHAS) on HA product synthesis in Escherichia coli. R413 was vital for HA production, as the removal or mutation of R413 led to inactivation of SeHAS. MD simulations indicated that R406-R413 constituted an HA-binding pattern that stabilized the HA-SeHAS complex. We further increased HA product size via site-directed mutation of the SeHAS C-terminal residues 414–417 based on the hypothesis that higher binding affinity between the SeHAS C-terminus and HA would lead to larger HA size, underlying the important role of the HA-SeHAS interaction in HA size control. W410A and T412A mutations also completely deactivated SeHAS. Moreover, a catalysis-transformation-translocation model was proposed for the HA synthesis and translocation processes

Luminal late loss upon 6-month follow-up.

<p>Luminal late loss upon 6-month follow-up.</p

Risk of bias.

<p>(A) Risk of bias graph. (B) Risk of bias summary.</p

Flowchart of articles included in the meta-analysis.

<p>Flowchart of articles included in the meta-analysis.</p

Pooled outcomes of MLD.

<p>Pooled outcomes of MLD.</p

Funnel plot of restenosis.

<p>Funnel plot of restenosis.</p