Meta-analysis Followed by Replication Identifies Loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as Associated with Systemic Lupus Erythematosus in Asians

Systemic lupus erythematosus (SLE) is a prototype autoimmune disease with a strong genetic involvement and ethnic differences. Susceptibility genes identified so far only explain a small portion of the genetic heritability of SLE, suggesting that many more loci are yet to be uncovered for this disease. In this study, we performed a meta-analysis of genome-wide association studies on SLE in Chinese Han populations and followed up the findings by replication in four additional Asian cohorts with a total of 5,365 cases and 10,054 corresponding controls. We identified genetic variants in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with the disease. These findings point to potential roles of cell-cycle regulation, autophagy, and DNA demethylation in SLE pathogenesis. For the region involving TET3 and that involving CDKN1B, multiple independent SNPs were identified, highlighting a phenomenon that might partially explain the missing heritability of complex diseases

The Relationship between NDVI and Climate Factors at Different Monthly Time Scales: A Case Study of Grasslands in Inner Mongolia, China (1982–2015)

There are currently only two methods (the within-growing season method and the inter-growing season method) used to analyse the normalized difference vegetation index (NDVI)–climate relationship at the monthly time scale. What are the differences between the two methods, and why do they exist? Which method is more suitable for the analysis of the relationship between them? In this study, after obtaining NDVI values (GIMMS NDVI3g) near meteorological stations and meteorological data of Inner Mongolian grasslands from 1982 to 2015, we analysed temporal changes in NDVI and climate factors, and explored the difference in Pearson correlation coefficients (R) between them via the above two analysis methods and analysed the change in R between them at multiple time scales. The research results indicated that: (1) NDVI was affected by temperature and precipitation in the area, showing periodic changes, (2) NDVI had a high value of R with climate factors in the within-growing season, while the significant correlation between them was different in different months in the inter-growing season, (3) with the increase in time series, the value of R between NDVI and climate factors showed a trend of increase in the within-growing season, while the value of R between NDVI and precipitation decreased, but then tended toward stability in the inter-growing season, and (4) when exploring the NDVI–climate relationship, we should first analyse the types of climate in the region to avoid the impacts of rain and heat occurring during the same period, and the inter-growing season method is more suitable for the analysis of the relationship between them

Spatial-Temporal Characteristics of Spring Maize Drought in Songnen Plain, Northeast China

With the intensification of global warming, food production will face serious drought risk. In view of the insufficient applicability of the existing crop drought index, a standardized crop water deficit index (SCWDI) was constructed based on the construction idea of the standardized precipitation evapotranspiration index (SPEI) and the crop water deficit index (CWDI) in this study. On this basis, the spatial and temporal characteristics of spring maize drought in Songnen Plain were explored by the slope trend analysis and Morlet wavelet analysis methods. The results show the following: (1) Compared with the existing drought index, the SCWDI shows obvious advantages in drought monitoring of spring maize. (2) In the whole growth stage of spring maize, the change trend of SCWDI was small in the temporal series (−0.012/10a). Spatially, the drought trend of spring maize was mainly decreasing (−0.14~0/10a). The drought frequency of spring maize in each growth stage was mainly light drought in most regions. (3) The three main drought cycles of spring maize in Songnen Plain were 29 years, 10 years, and 4 years. In the next few years, the drought of spring maize in Songnen Plain was controlled by the first main cycle, and the drought years may increase, which should be prevented. The research was expected to provide technical support for crop drought monitoring and agricultural disaster prevention

Characterization of polysaccharides and their antioxidant properties from Plumula nelumbinis

Two novel polysaccharides, Plumula nelumbinis (P. nelumbinis) polysaccharide I (LNP I) and P. nelumbinis polysaccharide II (LNP II), were extracted and purified from P. nelumbinis, and a sulfated polysaccharide, P. nelumbinis polysaccharide III (LNP III), with a substitution degree of 0.62 was prepared from LNPI. The structures of the LNPs were preliminarily characterized using high performance size exclusion chromatography (HPSEC), gas chromatography-mass spectrometry (GC–MS), Fourier transformed infrared spectrometry (FT-IR), and nuclear magnetic resonance (NMR) spectrometry. In addition, evaluation of the antioxidant activity of the LNPs showed that they could significantly increase the proliferation of RAW264.7 macrophages (P < 0.05) and improve the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) based on cell model of H2O2-induced oxidative damage. This suggested that these LNPs may be used as potential antioxidants. Keywords: Plumula nelumbinis, Polysaccharides, Sulfated modification, Antioxidant activit

Using Long-Term Earth Observation Data to Reveal the Factors Contributing to the Early 2020 Desert Locust Upsurge and the Resulting Vegetation Loss

Massive desert locust swarms have been threatening and devouring natural vegetation and agricultural crops in East Africa and West Asia since 2019, and the event developed into a rare and globally concerning locust upsurge in early 2020. The breeding, maturation, concentration and migration of locusts rely on appropriate environmental factors, mainly precipitation, temperature, vegetation coverage and land-surface soil moisture. Remotely sensed images and long-term meteorological observations across the desert locust invasion area were analyzed to explore the complex drivers, vegetation losses and growing trends during the locust upsurge in this study. The results revealed that (1) the intense precipitation events in the Arabian Peninsula during 2018 provided suitable soil moisture and lush vegetation, thus promoting locust breeding, multiplication and gregarization; (2) the regions affected by the heavy rainfall in 2019 shifted from the Arabian Peninsula to West Asia and Northeast Africa, thus driving the vast locust swarms migrating into those regions and causing enormous vegetation loss; (3) the soil moisture and NDVI anomalies corresponded well with the locust swarm movements; and (4) there was a low chance the eastwardly migrating locust swarms would fly into the Indochina Peninsula and Southwest China

Analyzing the Probability of Acquiring Cloud-Free Imagery in China with AVHRR Cloud Mask Data

Optical remote sensing data are used widely in many fields (such as agriculture, resource management and the environment), especially for the vast territory of China; however, the application of these data is usually limited by clouds. Although it is valuable to analyze the probability of acquiring cloud-free imagery (PACI), PACI using different sensors at the pixel level across China has not been reported. In this study, the PACI of China was calculated with daily Advanced Very High Resolution Radiometer (AVHRR) cloud mask data from 1990 to 2019. The results showed that (1) PACI varies dramatically in different regions and months in China. The value was larger in autumn and winter, and the largest figure reached 49.55% in October in Inner Mongolia (NM). In contrast, relatively small values occurred in summer, and the minimum value (5.26%) occurred in June in South China (SC). (2) As the climate changes, the PACI has increased significantly throughout the country and most regions, especially in North China (NC), with a growth rate of 1.9% per decade. The results can be used as a reference for selecting appropriate optical sensors and observation times in areas of interest

Changes in Fruit Quality Phytochemicals of Late-Mature Peach &lsquo;Yonglian No.1&rsquo; during Storage

In this study, the changes in quality parameters and sensory-influencing parameters from the peel, red flesh, and white flesh of &lsquo;Yonglian No.1&rsquo; peach fruits were analyzed during cold storage. The results indicated that the contents of total soluble solids (TSS), soluble sugar, organic acid, vitamin C, total anthocyanin, phenol, and flavonoids, as well as the good fruit rate varied depending on the storage stages and storage treatments. The peach fruits in MAP stored for 50 days had favorable exterior qualities, a good fruit rate of 100%, and a higher content of total soluble solids (TSS) at 12.6%. MAP was significantly effective at maintaining fruit firmness, the content of TSS, soluble sugar, organic acid, vitamin C, total anthocyanin, phenol, and flavonoids. Among the derivatives of anthocyanin, both cyanidin and pelargonidin were found in the peel, with a content of 33.45 mg/kg FW and 1.82 mg/kg FW, respectively. However, cyanidin was detected in the flesh with a content of 40.42 mg/kg FW. In the present work, the differences regarding phytochemical profiles and physical properties were mainly correlated with the storage stages and storage treatments of peach fruit. &lsquo;Yonglian No.1&rsquo; had higher levels of health-promoting compounds during storage and maintained favorable quality

Crosslinking kinetics of polycarbosilane precursor in ozone atmosphere and the formation mechanism of continuous hollow SiC fiber

Crosslinking kinetics of polycarbosilane precursor in ozone atmosphere and the formation mechanism of continuous hollow SiC fibe

Downregulation of Profilin-1 Expression Attenuates Cardiomyocytes Hypertrophy and Apoptosis Induced by Advanced Glycation End Products in H9c2 Cells

Cardiomyocytes hypertrophy and apoptosis induced by advanced glycation end products (AGEs) is the crucial pathological foundation contributing to the onset and development of diabetic cardiomyopathy (DCM). However, the mechanism remains poorly understood. Here, we report that profilin-1 (PFN-1), a well-known actin-binding protein, serves as a potent regulator in AGEs-induced cardiomyocytes hypertrophy and apoptosis. PFN-1 was upregulated in AGEs-treated H9c2 cells, which was associated with increased cardiomyocytes hypertrophy and apoptosis. Silencing PFN-1 expression remarkably attenuated AGEs-induced H9c2 cell hypertrophy and apoptosis. Mechanistically, AGEs increased PFN-1 expression through elevating ROS production and RhoA and ROCK2 expression. Consequently, elevated PFN-1 promoted actin cytoskeleton disorganization. When either ROS production/ROCK activation was blocked or cells were treated with Cytochalasin D (actin depolymerizer), H9c2 cells were protected against AGEs-induced cardiac myocyte abnormalities, concomitantly with downregulated expression of PFN-1 and improved actin cytoskeleton alteration. Collectively, these data suggest that PFN-1 may play an important role in AGEs-induced hypertrophy and apoptosis in H9c2 cells