Synthesis of Organic Dye-Impregnated Silica Shell-Coated Iron Oxide Nanoparticles by a New Method

A new method for preparing magnetic iron oxide nanoparticles coated by organic dye-doped silica shell was developed in this article. Iron oxide nanoparticles were first coated with dye-impregnated silica shell by the hydrolysis of hexadecyltrimethoxysilane (HTMOS) which produced a hydrophobic core for the entrapment of organic dye molecules. Then, the particles were coated with a hydrophilic shell by the hydrolysis of tetraethylorthosilicate (TEOS), which enabled water dispersal of the resulting nanoparticles. The final product was characterized by X-ray diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, photoluminescence spectroscopy, and vibration sample magnetometer. All the characterization results proved the final samples possessed magnetic and fluorescent properties simultaneously. And this new multifunctional nanomaterial possessed high photostability and minimal dye leakage

Bi-Functional Silica Nanoparticles Doped with Iron Oxide and CdTe Prepared by a Facile Method

Cadmium telluride (CdTe) and iron oxide nanoparticles doped silica nanospheres were prepared by a multistep method. Iron oxide nanoparticles were first coated with silica and then modified with amino group. Thereafter, CdTe nanoparticles were assembled on the particle surfaces by their strong interaction with amino group. Finally, an outer silica shell was deposited. The final products were characterized by X-ray powder diffraction, transmission electron microscopy, vibration sample magnetometer, photoluminescence spectra, Fourier transform infrared spectra (FT-IR), and fluorescent microscopy. The characterization results showed that the final nanomaterial possessed a saturation magnetization of about 5.8 emu g−1and an emission peak at 588 nm when the excitation wavelength fixed at 380 nm

Research on Personal Information Protection System of Network Information Platform under the Background of Big Data

The core of an Internet enterprise is the data of the network platform, which usually includes a large amount of personal data and personal information. Big data refers to the massive, high growth rate and diversified information assets that require new processing models to have stronger decision-making power, insight, and process optimization capabilities. It is characterized by a large number, high speed, variety, value density, and authenticity. There are ways and legal risks of leaking personal information everywhere on the network information platform. To effectively prevent and completely eliminate the leakage of personal privacy, the government should be taken as the leading factor and rely on all levels of society to deal with this issue from multiple angles

Bi-Functional Silica Nanoparticles Doped with Iron Oxide and CdTe Prepared by a Facile Method

Abstract Cadmium telluride (CdTe) and iron oxide nanoparticles doped silica nanospheres were prepared by a multistep method. Iron oxide nanoparticles were first coated with silica and then modified with amino group. Thereafter, CdTe nanoparticles were assembled on the particle surfaces by their strong interaction with amino group. Finally, an outer silica shell was deposited. The final products were characterized by X-ray powder diffraction, transmission electron microscopy, vibration sample magnetometer, photoluminescence spectra, Fourier transform infrared spectra (FT-IR), and fluorescent microscopy. The characterization results showed that the final nanomaterial possessed a saturation magnetization of about 5.8 emu g&#8722;1and an emission peak at 588 nm when the excitation wavelength fixed at 380 nm.</p

Diet-induced obesity in male C57BL/6 mice decreases fertility as a consequence of disrupted blood-testis barrier.

Obesity is a complex metabolic disease that is a serious detriment to both children and adult health, which induces a variety of diseases, such as cardiovascular disease, type II diabetes, hypertension and cancer. Although adverse effects of obesity on female reproduction or oocyte development have been well recognized, its harmfulness to male fertility is still unclear because of reported conflicting results. The aim of this study was to determine whether diet-induced obesity impairs male fertility and furthermore to uncover its underlying mechanisms. Thus, male C57BL/6 mice fed a high-fat diet (HFD) for 10 weeks served as a model of diet-induced obesity. The results clearly show that the percentage of sperm motility and progressive motility significantly decreased, whereas the proportion of teratozoospermia dramatically increased in HFD mice compared to those in normal diet fed controls. Besides, the sperm acrosome reaction fell accompanied by a decline in testosterone level and an increase in estradiol level in the HFD group. This alteration of sperm function parameters strongly indicated that the fertility of HFD mice was indeed impaired, which was also validated by a low pregnancy rate in their mated normal female. Moreover, testicular morphological analyses revealed that seminiferous epithelia were severely atrophic, and cell adhesions between spermatogenic cells and Sertoli cells were loosely arranged in HFD mice. Meanwhile, the integrity of the blood-testis barrier was severely interrupted consistent with declines in the tight junction related proteins, occludin, ZO-1 and androgen receptor, but instead endocytic vesicle-associated protein, clathrin rose. Taken together, obesity can impair male fertility through declines in the sperm function parameters, sex hormone level, whereas during spermatogenesis damage to the blood-testis barrier (BTB) integrity may be one of the crucial underlying factors accounting for this change

Alteration of serum lipids and sex hormone levels in HFD mice.

<p>(A) Comparison of serum lipid levels between CD and HFD groups; TG: triglycerides, TC: total cholesterol, LDL: low density lipoprotein, HDL: high density lipoprotein. (B) Comparison of serum sex hormone levels between CD and HFD groups, including testosterone, estradiol, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Data are expressed as mean ± SEM. * <i>P</i><0.05, ** <i>P</i><0.01.</p

HFD-induced androgen receptor, clathrin, ZO-1 and occludin expression changes in mice.

<p>(A) Western blot analyses of androgen receptor, clathrin, ZO-1 and occludin expression levels in testicular protein from CD and HFD mice. (B) Summary plot showing densitometric readings of the corresponding protein blots. Data are expressed as mean ± SEM. *<i>P</i><0.05, **<i>P</i><0.01.</p