Rapid removal of ultra-high-concentration <i>p</i>-nitrophenol in aqueous solution by microwave-enhanced Fe/Cu bimetallic particle (MW-Fe/Cu) system

<p>Ultra-high-concentration PNP-contained wastewaters are produced sometimes due to the wide application of this nitrophenolic compound in the chemical industry. However, there is a lack of appropriate technologies to rapidly pretreat the ultra-high-concentration wastewater. Therefore, a new microwave-enhanced Fe/Cu bimetallic particles (MW-Fe/Cu) system was developed to rapidly remove ultra-high-concentration PNP. First, the priority of the determinative parameters was obtained by orthogonal experiment. Based on this result, the effects of initial pH, microwave power, Fe/Cu dosage and initial PNP concentration on PNP removal were optimized thoroughly. Under the optimal conditions (i.e. initial pH = 1.0, MW power = 385 W, Fe/Cu dosage = 30 g/L and initial PNP concentration = 4000 mg/L), four control treatment systems (i.e. MW-Fe⁰, heating-Fe/Cu, MW alone and Fe/Cu alone system) were set up to compare with the MW-Fe/Cu system. The results suggest that high PNP removal (more than 99% with 2.5 min, <i>k</i>₁/<i>k</i>₂ = 1.18/6.91 min⁻¹) and COD removal (26.6% with 5 min treatment) could be obtained by the MW-Fe/Cu system, which were much superior to those obtained using the MW-Fe⁰ (<i>k</i>₁/<i>k</i>₂ = 0.62/2.21 min⁻¹) and the heating-Fe/Cu system (<i>k</i>₁/<i>k</i>₂ = 0.53/1.52 min⁻¹). Finally, the determination of the intermediates of PNP degradation by HPLC indicated that the MW assistance process did not change the degradation pathway of PNP. This concludes that the new MW-Fe/Cu system was the promising technology for pretreatment of wastewater containing ultra-high-concentration toxic and refractory pollutants at a fairly short treatment time.</p

An Approach for the Sphere-to-Rod Transition of Multiblock Copolymer Micelles

The shape of polymer micelles is important for pharmaceutical applications as drug delivery. In this article, an approach inducing sphere-to-rod transition of multiblock polyurethane micelles has been developed through introducing a second hydrophilic component phosphatidylcholine group into the polymer chains. Time-resolved dynamic light scattering (DLS), combined with transmission electron microscopy (TEM), was employed to investigate the kinetics of morphology transition. Moreover, a dissipative particle dynamics (DPD) simulation method was applied to study the mechanism of sphere-to-rod transition. These experimental and simulation studies revealed that the hydrophilic phosphatidylcholine groups can create defects on the surfaces of spherical polyurethane micelles, thus, making positive contribution to adhesive collisions and leading to the fusion of spherical micelles into rod-like micelles. This finding provides new insight into the origins of rod-like polymer micelles, which is valuable for the design and preparation of novel polymeric drug carriers with tailored properties

Multifunctional Mixed Micelles Cross-Assembled from Various Polyurethanes for Tumor Therapy

A challenge in the development of multifunctional drug delivery systems is to establish a reasonable and effective synthetic route for multifunctional polymer preparation. Herein, we propose a unique protocol to prepare multifunctional micelles by a cross-assembly process using three different functional polyurethanes incorporating acidic sensitive hydrazone, folic acid for active targeting, and gemini quaternary ammonium (GQA) as efficient cell uptake ligands, respectively. These multifunctional mixed micelles (GFHPMs) have been endowed tunable particle sizes and zeta potential and a unique three-order-layer cross-assemble structure. Their drug-loading contents have been significantly improved, and drug release profiles displayed controlled release of their payloads under acid condition. The folate and GQA ligands showed a synergistic effect to enhance the cell uptake. Biodistribution and antitumor effect of these micelles were systematically investigated in vivo, the mixed micelles could penetrate into the depths of tumors, and drug concentrations in tumors reached the maximum of 6.5% ID/g at 24 h, resulting in an excellent therapeutic effect that the volumes of tumors treated with GFHPM are five times smaller than those treated with blank micelles. Our present work provides an effective approach to the design of multifunctional nanocarriers for tumor-targeted and programmed intracellular drug delivery

Surface Distribution and Biophysicochemical Properties of Polymeric Micelles Bearing Gemini Cationic and Hydrophilic Groups

Polymeric micelles containing cationic gemini quaternary ammonium (GQA) groups have shown enhanced cellular uptake and efficient drug delivery, while the incorporation of poly­(ethylene glycol) (PEG) corona can potentially reduce the absorption of cationic carriers by opsonic proteins and subsequent uptake by mononuclear phagocytic system (MPS). To understand the interactions of GQA and PEG groups and their effects on the biophysicochemical characteristics of nanocarriers, a series of polyurethane micelles containing GQA and different molecular weights of PEG were prepared and carefully characterized. It was found that the GQA and PEG groups are unevenly distributed on the micellar surface to form two kinds of hydrophilic domains. As a result, the particle surface with some defects cannot be completely shielded by the PEG corona. Despite this, the longer PEG chains with a brush conformation provide superior stabilization and steric repulsion against the absorption of proteins and, thus, can reduce the cytotoxicity, protein absorption, and MPS uptake of micelles to some extent. This study provides a new understanding on the interactions between PEG chains and cationic groups and a guideline for the design and fabrication of safe and effective drug delivery systems

Additional file 2: of cepip: context-dependent epigenomic weighting for prioritization of regulatory variants and disease-associated genes

Descriptions and abbreviations of the 127 tissues/cell types. (XLSX 14 kb