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Calcineurin B-Like Proteins CBL4 and CBL10 Mediate Two Independent Salt Tolerance Pathways in Arabidopsis.
In Arabidopsis, the salt overly sensitive (SOS) pathway, consisting of calcineurin B-like protein 4 (CBL4/SOS3), CBL-interacting protein kinase 24 (CIPK24/SOS2) and SOS1, has been well defined as a crucial mechanism to control cellular ion homoeostasis by extruding Na+ to the extracellular space, thus conferring salt tolerance in plants. CBL10 also plays a critical role in salt tolerance possibly by the activation of Na+ compartmentation into the vacuole. However, the functional relationship of the SOS and CBL10-regulated processes remains unclear. Here, we analyzed the genetic interaction between CBL4 and CBL10 and found that the cbl4 cbl10 double mutant was dramatically more sensitive to salt as compared to the cbl4 and cbl10 single mutants, suggesting that CBL4 and CBL10 each directs a different salt-tolerance pathway. Furthermore, the cbl4 cbl10 and cipk24 cbl10 double mutants were more sensitive than the cipk24 single mutant, suggesting that CBL10 directs a process involving CIPK24 and other partners different from the SOS pathway. Although the cbl4 cbl10, cipk24 cbl10, and sos1 cbl10 double mutants showed comparable salt-sensitive phenotype to sos1 at the whole plant level, they all accumulated much lower Na+ as compared to sos1 under high salt conditions, suggesting that CBL10 regulates additional unknown transport processes that play distinct roles from the SOS1 in Na+ homeostasis
Individual position diversity in dependence socioeconomic networks increases economic output
The availability of big data recorded from massively multiplayer online
role-playing games (MMORPGs) allows us to gain a deeper understanding of the
potential connection between individuals' network positions and their economic
outputs. We use a statistical filtering method to construct dependence networks
from weighted friendship networks of individuals. We investigate the 30
distinct motif positions in the 13 directed triadic motifs which represent
microscopic dependences among individuals. Based on the structural similarity
of motif positions, we further classify individuals into different groups. The
node position diversity of individuals is found to be positively correlated
with their economic outputs. We also find that the economic outputs of leaf
nodes are significantly lower than that of the other nodes in the same motif.
Our findings shed light on understanding the influence of network structure on
economic activities and outputs in socioeconomic system.Comment: 19 pages, 5 figure
Clinical and pathological analysis of 504 cases of elderly ocular tumors
AIM:To analyze the composition, distribution and characteristics of the elderly primary ocular tumors. <p>METHODS: This was a retrospective study and all 504 cases with primary ocular tumors aged 60 years or older were collected in Shanxi Eye Hospital, during the year 2000-2012. The onset age, location and pathological pattern were analyzed.<p>RESULTS: There were 346 cases of benign ocular tumors(68.7%), and 158 cases of malignancy(31.3%).Papillomas was the most common type of the benign with 83 cases(16.5%), followed by a variety of inflammatory cysts and lesions with 69 cases(13.7%)and 64 cases(12.7%)respectively. Among malignant tumors cases, eyelid basal cell carcinoma originated from epithelial was the most common with 72 cases(14.3%), followed by skin appendages sources malignant tumors with 39 cases(7.7%). Concerning the location of ocular tumors, there were 282 cases of eyelid tumor(56.0%)occupied the first position followed by conjunctival tumor with 157 cases(31.2%). <p>CONCLUSION: The prevalence and type of primary ocular tumor in elderly people are significant differences from the general population and children's, and the proportion of malignant tumors tended to increase along with the increase of age
Carbon monoxide in an extremely metal-poor galaxy
Extremely metal-poor galaxies with metallicity below 10% of the solar value
in the local universe are the best analogues to investigating the interstellar
medium at a quasi-primitive environment in the early universe. In spite of the
ongoing formation of stars in these galaxies, the presence of molecular gas
(which is known to provide the material reservoir for star formation in
galaxies, such as our Milky Way) remains unclear. Here, we report the detection
of carbon monoxide (CO), the primary tracer of molecular gas, in a galaxy with
7% solar metallicity, with additional detections in two galaxies at higher
metallicities. Such detections offer direct evidence for the existence of
molecular gas in these galaxies that contain few metals. Using archived
infrared data, it is shown that the molecular gas mass per CO luminosity at
extremely low metallicity is approximately one-thousand times the Milky Way
value.Comment: 12 pages, 3 figures, 1 table. Supplementary data at
http://www.nature.com/article-assets/npg/ncomms/2016/161209/ncomms13789/extref/ncomms13789-s1.pd
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