Ervadivamines A and B, Two Unusual Trimeric Monoterpenoid Indole Alkaloids from <i>Ervatamia divaricata</i>

Ervadivamines A (<b>1</b>) and B (<b>2</b>), two unprecedented trimeric monoterpenoid indole alkaloids, were isolated from <i>Ervatamia divaricata</i>. They are the first examples of vobasine-iboga-vobasine-type alkaloid with both C–C and C–N linkage patterns. Their structures including absolute configurations were fully accomplished by extensive spectroscopic analysis, single-crystal X-ray diffraction, and electric circular dichroism methods. The plausible biogenetic pathways of these trimeric alkaloids were also proposed. In addition, compound <b>1</b> exhibited significant cytotoxicity against four cancer cells

Ervadivamines A and B, Two Unusual Trimeric Monoterpenoid Indole Alkaloids from <i>Ervatamia divaricata</i>

Ervadivamines A (<b>1</b>) and B (<b>2</b>), two unprecedented trimeric monoterpenoid indole alkaloids, were isolated from <i>Ervatamia divaricata</i>. They are the first examples of vobasine-iboga-vobasine-type alkaloid with both C–C and C–N linkage patterns. Their structures including absolute configurations were fully accomplished by extensive spectroscopic analysis, single-crystal X-ray diffraction, and electric circular dichroism methods. The plausible biogenetic pathways of these trimeric alkaloids were also proposed. In addition, compound <b>1</b> exhibited significant cytotoxicity against four cancer cells

Ervadivamines A and B, Two Unusual Trimeric Monoterpenoid Indole Alkaloids from <i>Ervatamia divaricata</i>

Ervadivamines A (<b>1</b>) and B (<b>2</b>), two unprecedented trimeric monoterpenoid indole alkaloids, were isolated from <i>Ervatamia divaricata</i>. They are the first examples of vobasine-iboga-vobasine-type alkaloid with both C–C and C–N linkage patterns. Their structures including absolute configurations were fully accomplished by extensive spectroscopic analysis, single-crystal X-ray diffraction, and electric circular dichroism methods. The plausible biogenetic pathways of these trimeric alkaloids were also proposed. In addition, compound <b>1</b> exhibited significant cytotoxicity against four cancer cells