10,605 research outputs found
A note on model structures on arbitrary Frobenius categories
We show that there is a model structure in the sense of Quillen on an
arbitrary Frobenius category \F such that the homotopy category of this model
structure is equivalent to the stable category \underline{\F} as triangulated
categories.Comment: withdraw the extension lifting lemma which is not used for the proof
of the main resul
A hidden spatial-temporal Markov random field model for network-based analysis of time course gene expression data
Microarray time course (MTC) gene expression data are commonly collected to
study the dynamic nature of biological processes. One important problem is to
identify genes that show different expression profiles over time and pathways
that are perturbed during a given biological process. While methods are
available to identify the genes with differential expression levels over time,
there is a lack of methods that can incorporate the pathway information in
identifying the pathways being modified/activated during a biological process.
In this paper we develop a hidden spatial-temporal Markov random field
(hstMRF)-based method for identifying genes and subnetworks that are related to
biological processes, where the dependency of the differential expression
patterns of genes on the networks are modeled over time and over the network of
pathways. Simulation studies indicated that the method is quite effective in
identifying genes and modified subnetworks and has higher sensitivity than the
commonly used procedures that do not use the pathway structure or time
dependency information, with similar false discovery rates. Application to a
microarray gene expression study of systemic inflammation in humans identified
a core set of genes on the KEGG pathways that show clear differential
expression patterns over time. In addition, the method confirmed that the
TOLL-like signaling pathway plays an important role in immune response to
endotoxins.Comment: Published in at http://dx.doi.org/10.1214/07--AOAS145 the Annals of
Applied Statistics (http://www.imstat.org/aoas/) by the Institute of
Mathematical Statistics (http://www.imstat.org
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