High Sensitivity and High Detection Specificity of Gold-Nanoparticle-Grafted Nanostructured Silicon Mass Spectrometry for Glucose Analysis

Desorption/ionization on silicon (DIOS) is a high-performance matrix-free mass spectrometry (MS) analysis method that involves using silicon nanostructures as a matrix for MS desorption/ionization. In this study, gold nanoparticles grafted onto a nanostructured silicon (AuNPs-nSi) surface were demonstrated as a DIOS-MS analysis approach with high sensitivity and high detection specificity for glucose detection. A glucose sample deposited on the AuNPs-nSi surface was directly catalyzed to negatively charged gluconic acid molecules on a single AuNPs-nSi chip for MS analysis. The AuNPs-nSi surface was fabricated using two electroless deposition steps and one electroless etching step. The effects of the electroless fabrication parameters on the glucose detection efficiency were evaluated. Practical application of AuNPs-nSi MS glucose analysis in urine samples was also demonstrated in this study

Additional file 1 of Mechanism of salidroside against coronary artery disease by network pharmacology analysis

Additional file 1: Supplementary Table 1. Targets of salidroside, CAD, and salidroside in the treatment of CAD

Additional file 3 of Mechanism of salidroside against coronary artery disease by network pharmacology analysis

Additional file 3: Supplementary Table 3. Twenty-five gene sets and genes related to angiogenesis in MSigDB

Additional file 2 of Mechanism of salidroside against coronary artery disease by network pharmacology analysis

Additional file 2: Supplementary Table 2. Enrichment analysis of salidroside-related targets and targets for treatment of CAD