The survival effect of neoadjuvant therapy and neoadjuvant plus adjuvant therapy on pancreatic ductal adenocarcinoma patients with different TNM stages: a propensity score matching analysis based on the SEER database

Adjuvant therapy (AT) and neoadjuvant therapy (NAT) are standard treatments for pancreatic ductal adenocarcinoma (PDAC) depending on the status of the disease. However, whether AT improves survival after NAT and radical resection in all TNM stages remains unclear. We utilized the Surveillance, Epidemiology, and End Results (SEER) database (2010–2019) for PDAC patients who underwent radical surgery and applied Pearson’s chi-square test, multivariate and univariate Cox regression, Kaplan-Meier plot, Log-rank tests, and propensity score matching (PSM) for analysis. Given PSM after enrolling 13,868 PDAC patients, significant differences in survival were identified between AT and neoadjuvant therapy plus adjuvant therapy (NATAT) (p = 0.023) as well as between NAT and NATAT (p  In this retrospective cohort study, we demonstrated that patients harboring tumors in late TNM stages, including N2 resectable PDAC, might have better survival from NATAT, and that certain patients with M1 disease might still benefit from comprehensive systemic therapy and radical resection.</p

Additional file 1: Table S1. of Assessing the adequacy of lymph node yield for different tumor stages of colon cancer by nodal staging scores

Probability of missing nodal disease (false negative, %) for selected values of the number of nodes examined. Table S2. Nodal staging score for selected values of the number of nodes examined. (DOCX 54 kb

Comparison of different uptake patterns in ¹⁸F-AIF-NOTA-PRGD2 PET and ¹⁸F-FDG PET.

<p>The enlarged lymph node identified on CT (A1 and B1) had significantly higher uptake of ¹⁸F-FDG PET (B2–B3) than that for ¹⁸F-AIF-NOTA-PRGD2 (A2–A3).</p

Comparison of SUVs from ¹⁸F-FDG PET and ¹⁸F-AIF-NOTA-PRGD2 PET for all malignant lesions.

<p>Comparison of SUVs from ¹⁸F-FDG PET and ¹⁸F-AIF-NOTA-PRGD2 PET for all malignant lesions.</p

Additional file 1: Figure S1. of Lymphocyte count or percentage: which can better predict the prognosis of advanced cancer patients following palliative care?

Flow chart of patients excluded from the study. (DOCX 28 kb

Electrochemical Behavior of the Biomass Hard Carbon Derived from Waste Corncob as a Sodium-Ion Battery Anode

Biomass-derived hard carbon exhibits remarkable potential as an anode material for sodium-ion batteries (SIBs) owing to its inexpensive cost, availability of resources, and excellent electrochemical performance. However, the relatively low initial Coulombic efficiency (ICE) significantly confines the realistic application of hard carbon anode materials in SIBs. In this work, corncob-derived hard carbon (CDHC) materials were synthesized from biomass waste corncob. It has been found that the interlayer spacing of the synthesized hard carbon material is greater than 0.37 nm, which clearly surpasses the layer spacing of graphite. This larger layer spacing is favorable for the intercalation and deintercalation ability of sodium ions during the charging and discharging processes. When CDHC is applied by the anode of sodium-ion batteries, it shows excellent sodium storage performance, with a maximum reversible capacity of approximately 311 mAh g–1 and the first Coulombic efficiency close to 80%

Association between weekly percentage of ILI consultations in the Age 0–5, 5–15 and Age 25–60 groups.

<p>(A) Age-specific normalized weekly ILI time series for Ages 0–5 (red), Ages 5–15 (green), and Ages 25–60 (black); (B) Phase differences between Ages 0–5 and Ages 25–60 (red dashed lines) and between Ages 5–15 and Ages 25–60 (green dashed lines).</p

Association between normalized weekly percentages of ILI consultations (ILI) and weekly proportion of positive laboratory-confirmed cases of influenza A and B (LAB).

<p>(A) Normalized weekly percentage of ILI consultations and laboratory-confirmed cases of influenza (A and B); (B) Cross wavelet transform of the LAB and ILI time series. The power values were colored in Fig 2B. The black solid contour lines indicate the regions of power significant at the 95% confidence level which can be assumed to be a true feature. The region outside the black-curved cone indicates the presence of edge effects and is not drawn as the evidence for conclusions. (C) Phases of LAB and ILI time series (solid lines, colors as in Fig 2A) and their phase difference (black dashed lines).</p

Annual numbers of specimens tested for influenza infection, number of positive specimens (including type A, type B and uncategorized), averaged weekly percentage (AWP) of influenza cases and averaged weekly consultation rates of influenza-like illness, 2008–2015.

<p>Annual numbers of specimens tested for influenza infection, number of positive specimens (including type A, type B and uncategorized), averaged weekly percentage (AWP) of influenza cases and averaged weekly consultation rates of influenza-like illness, 2008–2015.</p

Additional file 1: Table S1. of miR-124-3p functions as a tumor suppressor in breast cancer by targeting CBL

Patients’ Characteristics. (DOCX 17 kb