R2DE: a NLP approach to estimating IRT parameters of newly generated questions

The main objective of exams consists in performing an assessment of students' expertise on a specific subject. Such expertise, also referred to as skill or knowledge level, can then be leveraged in different ways (e.g., to assign a grade to the students, to understand whether a student might need some support, etc.). Similarly, the questions appearing in the exams have to be assessed in some way before being used to evaluate students. Standard approaches to questions' assessment are either subjective (e.g., assessment by human experts) or introduce a long delay in the process of question generation (e.g., pretesting with real students). In this work we introduce R2DE (which is a Regressor for Difficulty and Discrimination Estimation), a model capable of assessing newly generated multiple-choice questions by looking at the text of the question and the text of the possible choices. In particular, it can estimate the difficulty and the discrimination of each question, as they are defined in Item Response Theory. We also present the results of extensive experiments we carried out on a real world large scale dataset coming from an e-learning platform, showing that our model can be used to perform an initial assessment of newly created questions and ease some of the problems that arise in question generation

Grain Oriented Crystallization, Piezoelectric, and Pyroelectric Properties of (BaxSr₂ - X)TiSi₂O₈ Glass Ceramics

Polar, nonferroelectric (BaxSr2 - x)TiSi2O8 glass ceramics with highly oriented crystallites were prepared by a gradient temperature heat treatment technique. The crystallization mechanism and microstructures of (BaxSr2 - x)TiSi2O8 glass ceramics were investigated by means of differential thermal analysis, x-ray diffraction and scanning electron microscopy, and the dielectric, piezoelectric and pyroelectric properties were investigated for various compositions. The results show that polar (BaxSr2 - x)TiSi2O8 glass ceramics have a low dielectric constant and a high hydrostatic figure of merit dh × gh = ~ 2500. This high hydrostatic figure of merit, along with other unique characteristics, such as no aging or depoling problems and good stability at high temperatures, high pressure, and in harsh environments, makes (BaxSr2 - x)TiSi2O8 glass ceramics attractive for use as hydrophones and high temperature infrared detectors

Assessment of the impact of intravenous antibiotics treatment on gut microbiota in patients: Clinical data from pre-and post-cardiac surgery

Background and aimsSurgical site infection is a common complication after surgery. Periprocedural antibiotics are necessary to prescribe for preventing or treating infections. The present study aimed to explore the effect of intravenous antibiotics on gut microbiota and menaquinone biosynthesis in patients, especially in elderly patients undergoing cardiac surgery.MethodsA total of 388 fecal samples were collected from 154 cardiac surgery patients. The V3–V4 hypervariable region of the bacterial 16S rRNA gene was amplified and sequenced on a MiSeq PE300. The gut microbiota diversity of samples was analyzed in terms of α- and β-diversity at the OTU level. The different groups were classified according to antibiotics in combinations and single antibiotics. PICRUSt2 was used for preliminary prediction of the gut microbiota function for menaquinone biosynthesis.ResultsThe intravenously administered antibiotics which are excreted via bile represents the main antibiotics that could disturb the gut microbiota’s composition in cardiac surgery patients, especially for elderly patients. The effect of antibiotics on gut microbiota is produced after antibiotics treatments over one week. The recovery of gut microbiota to the state of pre-antibiotics may require over two weeks of antibiotics withdrawal. Sex factor doesn’t represent as an influencer in gut microbiota composition. Long-term use of cefoperazone-sulbactam may affect coagulation function.ConclusionsThe composition of the gut microbiota had a significant change post-intravenous antibiotics treatment in cardiac surgery patients. The richness and diversity of gut microbiota are increased in elderly patients

Criteria for determining the need for surgical treatment of tricuspid regurgitation during mitral valve replacement

<p>Abstract</p> <p>Background</p> <p>Tricuspid regurgitation (TR) is common in patients with mitral valve disease; however, there are no straightforward, rapidly determinably criteria available for deciding whether TR repair should be performed during mitral valve replacement. The aim of our retrospective study was to identify a simple and fast criterion for determining whether TR repair should be performed in patients undergoing mitral valve replacement.</p> <p>Methods</p> <p>We reviewed the records of patients who underwent mitral valve replacement with or without (control) TR repair (DeVega or Kay procedure) from January 2005 to December 2008. Preoperative and 2-year postoperative echocardiographic measurements included right ventricular and atrial diameter, interventricular septum size, TR severity, ejection fraction, and pulmonary artery pressure.</p> <p>Results</p> <p>A total of 89 patients were included (control, n = 50; DeVega, n = 27; Kay, n = 12). Demographic and clinical characteristics were similar between groups. Cardiac variables were similar between the DeVega and Kay groups. Right atrium and ventricular diameter and ejection fraction were significantly decreased postoperatively both in the control and operation (DeVega + Kay) group (<it>P </it>< 0.05). Pulmonary artery pressure was significantly decreased postoperatively in-operation groups (<it>P </it>< 0.05). Our findings indicate that surgical intervention for TR should be considered during mitral valve replacement if any of the following preoperative criteria are met: right atrial transverse diameter > 57 mm; right ventricular end-diastolic diameter > 55 mm; pulmonary artery pressure > 58 mmHg.</p> <p>Conclusions</p> <p>Our findings suggest echocardiography may be used as a rapid and simple means of determining which patients require TR repair during mitral valve replacement.</p

Effects of O₂/Ar Ratio on Preparation and Dielectric Properties of CaZrO₃ Films by Radio Frequency (RF) Magnetron Sputtering

CaZrO3 (CZO) thin films were deposited on Pt/Ti/SiO2/Si substrates at 450 °C by radio-frequency magnetron sputtering technology. The microstructures and dielectric properties of CZO thin films were investigated. X-ray diffraction analysis reveals that the perovskite orthogonal CZO phase would be promoted by a higher O2 partial pressure in the flow ratio of O2/Ar after thin films were annealed at 700 °C for 3 h in air. The films prepared under the flow ratio of O2/Ar (20:40, 30:40 and 40:40) show the main perovskite crystal phase of CaZrO3 with a small amount of Ca0.2Zr0.8O1.8. The main crystal phase was Ca0.2Zr0.8O1.8 when the film was deposited under an O2/Ar ratio of 40:10. The annealed film with a 40:40 O2/Ar ratio exhibits a dielectric performance with a high dielectric constant (εr) of 25 at 1 MHz, a temperature coefficient of permittivity of not more than 122.7 ppm/°C from 0 °C to 125 °C, and a low leakage current density of about 2 × 10−7 A/cm2 at 30 V with an ohmic conduction mechanism

R2DE: A NLP approach to estimating IRT parameters of newly generated questions

The main objective of exams consists in performing an assessment of students' expertise on a specific subject. Such expertise, also referred to as skill or knowledge level, can then be leveraged in different ways (e.g., to assign a grade to the students, to understand whether a student might need some support, etc.). Similarly, the questions appearing in the exams have to be assessed in some way before being used to evaluate students. Standard approaches to questions' assessment are either subjective (e.g., assessment by human experts) or introduce a long delay in the process of question generation (e.g., pretesting with real students). In this work we introduce R2DE (which is a Regressor for Difficulty and Discrimination Estimation), a model capable of assessing newly generated multiple-choice questions by looking at the text of the question and the text of the possible choices. In particular, it can estimate the difficulty and the discrimination of each question, as they are defined in Item Response Theory. We also present the results of extensive experiments we carried out on a real world large scale dataset coming from an e-learning platform, showing that our model can be used to perform an initial assessment of newly created questions and ease some of the problems that arise in question generation. © 2020 Copyright held by the owner/author(s)

Upper-Bound Finite Element Adaptive Analysis of Plane Strain Heading in Soil with a Soft Upper Layer and Hard Lower Layer

This paper investigates the stability of a rectangular tunnel face affected by surcharge loading in soil with a soft upper layer and hard lower layer using upper-bound finite element methods with a plastic-dissipation-based mesh adaptive strategy (UBFEM-PDMA). Seven different positions for the soil interface are selected to study this problem. The upper bounds on the ultimate surcharge loads σs are presented in terms of dimensionless stability charts. The σs increases with tunnel depth, and it increases when the position of the soil interface moves up along the tunnel face. The failure mechanism primarily involves a wedge-shaped zone around the tunnel face and two slip lines originating from the top and bottom of the tunnel face, and it is mainly influenced by three factors, i.e., the position of the soil interface, the soil properties, and the tunnel depth. In contrast to the failure mechanism for uniform soil, multiple slip lines exist in the tunnel face in soil with a soft upper layer and hard lower layer. The results compare reasonably well with those in the literature and those from the numerical method

Wnt signaling in physiological and pathological bone formation

Wnt signaling, canonical or non-canonical, plays conserved roles in numerous physiological and pathological processes. However, it is well beyond the scope of this review to cover all functional aspects of Wnt signaling in different contexts at reasonable depth; therefore this review intends to cover only the roles of Wnt signaling in bone biology; more specifically, we intend to first update the roles of Wnt signaling in physiological bone process, including in osteogenesis and chondrogenesis, since recent years have witnessed tremendous progressions in this area, and then we seek to extend our understanding to the pathological bone process, especially to the heterotopic ossification (HO), even though the understanding of Wnt signaling in HO has been limited. We then further clarify the potential crosstalking between Wnt and other conserved signaling pathways, including FGF, GPCR and Hif1α pathways. Overall, our goal is to update the progressions, identify the general theme and the knowledge gaps and discuss the potential promising avenue for future applications in HO prevention and treatment