Anelastic attenuation in cubic and hexagonal iron alloys: Implications for the core

<p>Poster presented at AGU Fall Meeting 2013. San Francisco.</p> <p>MR21A-2330, Anelastic attenuation in cubic and hexagonal iron alloys: implications for the core, Simon Redfern and Zhenwei Peng, 10th December 2013.</p

Safety margin after radiofrequency ablation of hepatocellular carcinoma: precise assessment with a three-dimensional reconstruction technique using CT imaging

<p><b>Purpose:</b> To analyse the precise ablative margin (AM) after radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) and the correlation between AM and local tumour progression (LTP) with a three-dimension (3D) reconstruction technique.</p> <p><b>Methods:</b> From March 2011 to May 2013, 134 patients who underwent RFA for 159 primary or recurrent HCCs within Milan criteria were enrolled. Contrast-enhanced computed tomography (CECT) scans were performed 1 week before and 1 month after treatment. The AM was measured in various directions using a 3D reconstruction technique that shows the index tumour and ablated zone on the same image. The average of all obtained AMs (average AM) and the smallest AM (min-AM) were calculated.</p> <p><b>Results:</b> The min-AM after RFA ranged from 1 to 9.3 mm (median ± standard deviation, 4.8 ± 1.8 mm). LTP was observed in 19 tumours from 19 patients. The median min-AM was 3.1 ± 1.6 mm for patients with LTP, while the median min-AM of patients without LTP was 5.1 ± 1.8 mm (<i>p</i> = 0.023). After RFA, the 1-, 2- and 3-year LTP rates were 10.9, 25.9 and 35.1%, respectively, for patients with min-AM <5 mm, and 4.1, 4.1 and 4.1%, respectively, for patients with min-AM ≥5 mm (<i>p</i> = 0.016). Multivariate analysis showed that only min-AM <5 mm was an independent risk factor for LTP after RFA (<i>p</i> = 0.044, hazard ratio =4.587, 95% confidence interval, 1.045–22.296).</p> <p><b>Conclusions:</b> The 3D reconstruction technique is a precise method for evaluating the post-ablation margin. Patients with min-AM less than 5 mm had a higher probability of developing LTP.</p

Graphs show the overall survival curves for patients with postoperative NLR decreased and increased after RFA.

<p>The difference between groups were statistically significant (log-rank test, <i>P</i><0.001).</p

Cox proportional hazards model of baseline prognosticators for new recurrence in 178 patients with small HCC undergoing RFA.

<p>AFP, a-fetoprotein; CI, confidence interval; HBeAg, hepatitis B e-antigen; HR, hazard ratio; NLR, neutrophil-lymphocyte ratio; RFA, radiofrequency ablation.</p

Graphs show the overall survival curves for patients with preoperative NLR≥1.9 and NLR<1.9.

<p>The difference between groups were statistically significant (log-rank test, <i>P</i> = 0.030).</p

Graphs show the recurrence free survival curves for patients with preoperative NLR≥1.9 and NLR<1.9.

<p>The difference between groups were not statistically significant (log-rank test, <i>P</i> = 0.859).</p

Graphs show the overall survival curves for different subgroup patients with postoperative NLR decreased and increased after RFA.

<p>Graphs show the overall survival curves for different subgroup patients with postoperative NLR decreased and increased after RFA.</p

Graphs show the recurrence free survival curves for patients with postoperative NLR decreased and increased after RFA.

<p>The difference between groups were statistically significant (log-rank test, <i>P</i><0.001).</p

Cox proportional hazards model of baseline prognosticators for overall survival in 178 patients with small HCC undergoing RFA.

<p>AFP, a-fetoprotein; CI, confidence interval; HBeAg, hepatitis B e-antigen; HR, hazard ratio; NLR, neutrophil-lymphocyte ratio; RFA, radiofrequency ablation.</p

Additional file 10: of Sorafenib versus Transarterial chemoembolization for advanced-stage hepatocellular carcinoma: a cost-effectiveness analysis

Table S9. References used to derive monthly mortality of advanced HCC patients with decompensated cirrhosis. (DOCX 12 kb