Towards many body physics with ultracold NaK molecules

This thesis reports on the construction of a novel experimental apparatus to create an ultracold sample of chemical stable $^{23}\rm{Na}^{40}\rm{K}$ polar molecules at their absolute ground states. The long range nature of the dipolar interactions between the ground state molecules, is expected to facilitate to observe new quantum many-body states and to simulate prototypical lattice spin models for exploring quantum magnetism and high $T_c$ superconductivity. The experimental procedures are presented in this thesis including: trapping and cooling $^{23}\rm{Na}$ and $^{40}\rm{K}$ atoms to quantum degeneracy, associating weakly bound state molecules with Feshbach resonances, and transferring the Feshbach molecules to the rovibrational ground states via stimulated Raman adiabatic passage. As a result, successful transfer has been demonstrated in our experiment with a single-path transfer efficiency $\simeq 60\%$ via a hyperfine non-resolved intermediate state $\vert d^{3}\Pi, \nu=5, J=1, \Omega=1 \rangle$. In addition, a perturbative theoretical study on the Fermi liquid properties of a single-component weakly-interacting two dimensional dipolar fermions with dipole moments $d$ oriented perpendicularly to the plane of their translational motion is presented in the thesis. When the dipole moments are tilted with respect to the translational plane, the effect of anisotropic interaction appears, and collective excitations in the collisionless regime are studied in this configuration. Furthermore, stable dilute supersolid states with two-dimensional bosonic dipoles are predicted to exist with an additional three-body repulsive contact interaction. These novel quantum effects should be accessible experimentally once the $\rm{Na}\rm{K}$ ground state molecules reach quantum degeneracy by further evaporative cooling.Deutsche Übersetzung des Titels: Vielteilchenphysik mit ultrakalten NaK Moleküle

Quantification of the influence of drugs on zebrafish larvae swimming kinematics and energetics

The use of zebrafish larvae has aroused wide interest in the medical field for its potential role in the development of new therapies. The larvae grow extremely quickly and the embryos are nearly transparent which allows easy examination of its internal structures using fluorescent imaging techniques. Medical treatment of zebrafish larvae can directly influence its swimming behaviours. These behaviour changes are related to functional changes of central nervous system and transformations of the zebrafish body such as muscle mechanical power and force variation, which cannot be measured directly by pure experiment observation. To quantify the influence of drugs on zebrafish larvae swimming behaviours and energetics, we have developed a novel methodology to exploit intravital changes based on observed zebrafish locomotion. Specifically, by using an in-house MATLAB code to process the recorded live zebrafish swimming video, the kinematic locomotion equation of a 3D zebrafish larvae was obtained, and a customised Computational Fluid Dynamics tool was used to solve the fluid flow around the fish model which was geometrically the same as experimentally tested zebrafish. The developed methodology was firstly verified against experiment, and further applied to quantify the fish internal body force, torque and power consumption associated with a group of normal zebrafish larvae vs. those immersed in acetic acid and two neuroactive drugs. As indicated by our results, zebrafish larvae immersed in 0.01% acetic acid display approximately 30% higher hydrodynamic power and 10% higher cost of transport than control group. In addition, 500 μM diphenylhydantoin significantly decreases the locomotion activity for approximately 50% lower hydrodynamic power, whereas 100 mg/L yohimbine has not caused any significant influences on 5 dpf zebrafish larvae locomotion. The approach has potential to evaluate the influence of drugs on the aquatic animal’s behaviour changes and thus support the development of new analgesic and neuroactive drugs

A colour preference technique to evaluate acrylamide-induced toxicity in zebrafish

The zebrafish has become a commonly used vertebrate model for toxicity assessment, of particular relevance to the study of toxic effects on the visual system because of the structural similarities shared by zebrafish and human retinae. In this article we present a colour preference-based technique that, by assessing the functionality of photoreceptors, can be used to evaluate the effects of toxicity on behaviour. A digital camera was used to record the locomotor behaviour of individual zebrafish swimming in a water tank consisting of two compartments separated by an opaque perforated wall through which the fish could pass. The colour of the lighting in each compartment could be altered independently (producing distinct but connected environments of white, red or blue) to allow association of the zebrafish's swimming behaviour with its colour preference. The functionality of the photoreceptors was evaluated based on the ability of the zebrafish to sense the different colours and to swim between the compartments. The zebrafish tracking was carried out using our algorithm developed with MATLAB. We found that zebrafish preferred blue illumination to white, and white illumination to red. Acute treatment with acrylamide (2 mM for 36 h) resulted in a marked reduction in locomotion and a concomitant loss of colour-preferential swimming behaviour. Histopathological examination of acrylamide-treated zebrafish eyes showed that acrylamide exposure had caused retinal damage. The colour preference tracking technique has applications in the assessment of neurodegenerative disorders, as a method for preclinical appraisal of drug efficacy and for behavioural evaluation of toxicity

Improving Denoising Diffusion Models via Simultaneous Estimation of Image and Noise

This paper introduces two key contributions aimed at improving the speed and quality of images generated through inverse diffusion processes. The first contribution involves reparameterizing the diffusion process in terms of the angle on a quarter-circular arc between the image and noise, specifically setting the conventional $\displaystyle \sqrt{\bar{\alpha}}=\cos(\eta)$. This reparameterization eliminates two singularities and allows for the expression of diffusion evolution as a well-behaved ordinary differential equation (ODE). In turn, this allows higher order ODE solvers such as Runge-Kutta methods to be used effectively. The second contribution is to directly estimate both the image ($\mathbf{x}_0$) and noise ($\mathbf{\epsilon}$) using our network, which enables more stable calculations of the update step in the inverse diffusion steps, as accurate estimation of both the image and noise are crucial at different stages of the process. Together with these changes, our model achieves faster generation, with the ability to converge on high-quality images more quickly, and higher quality of the generated images, as measured by metrics such as Frechet Inception Distance (FID), spatial Frechet Inception Distance (sFID), precision, and recall

Research on the Design of Chinese Rural Homestay Inn Based on the Concept of Symbiosis

This dissertation considers rural homestay inns' design as the starting point based on symbiosis. It discusses the symbiotic relationship between the architecture of rural homestay inns and the economic structure, natural environment, and folk culture from the macro, meso, and microlevels. The development of rural homestay inns is not isolated. Forming an excellent symbiotic relationship between different homestays in the village is the foundation for achieving the industrial structure's complementarity. The core of the design of the rural homestay inn is the in-depth excavation of local cultural customs and natural resources. In the design process, it continues and inherits the local historical features and architectural culture so that tourists can experience the local feelings. This article takes Huanghu Village as a practical case. It develops the design of a rural homestay inn in detail under the concept of symbiosis. It includes the symbiosis of country house and environment, culture, symbiosis of interior and exterior spaces of buildings, and symbiosis of building materials, etc. It is hoped that through practice, the quality of rural homestay inns in Wuhan will be improved, the recovery of rural tourism will be promoted, and the development of the rural economy will be promoted