レーザ粉末床溶融結合方式（LPBF）による多孔質Ti-6Al-4V合金の造形

Tohoku University博士（工学）要約のみthesi

Charmless decays B -> PP, PV, and effects of new strong and electroweak penguins in Topcolor-assisted Technicolor model

Based on the low energy effective Hamiltonian with generalized factorization, we calculate the new physics contributions to the branching ratios and CP-violating asymmetries of the two-body charmless hadronic decays $B \to PP, PV$ from the new strong and electroweak penguin diagrams in the TC2 model. The top-pion penguins dominate the new physics corrections, and both new gluonic and electroweak penguins contribute effectively to most decay modes. For tree-dominated decay modes $B \to \pi \pi, \rho \pi, etc,$ the new physics corrections are less than 10%. For decays $B \to K^{(*)} \pi$, $K^{(*)} \eta$, $etc$, the new physics enhancements can be rather large (from $- 70$ to $\sim 200$) and are insensitive to the variations of $N_c^{eff}$, $k^2$, $\eta$ and $m_{\tilde{\pi}}$ within the reasonable ranges. For decays $B^0 \to \phi \pi$, $\phi \eta^{(')}$, $K^* \bar{K}^0$ and $\rho^+ K^0$, $\delta {\cal B}$ is strongly $N_c^{eff}-$dependent: varying from -90% to $\sim 1680$ in the range of $N_c^{eff}=2-\infty$. The new physics corrections to the CP-violating asymmetries ${\cal A}_{CP}$ vary greatly for different B decay channels. For five measured CP asymmetries of $B \to K \pi, K \eta', \omega \pi$ decays, $\delta {\cal A}_{CP}$ is only about 20% and will be masked by large theoretical uncertainties. The new physics enhancements to interesting $B \to K \eta'$ decays are significant in size ($\sim 50$), insensitive to the variations of input parameters and hence lead to a plausible interpretation for the unexpectedly large $B \to K \eta'$ decay rates. The TC2 model predictions for branching ratios and CP-violating asymmteries of all fifty seven $B \to PP, PV$ decay modes are consistent with the available data within one or two standard deviations.Comment: Latex file, 56 pages with 11 ps and eps figures. to be published in Eur.Phys.J.

The rare K-decays and Z0Z^0-penguin contributions in the Topcolor-assisted technicolor models

We calculate the new contributions to the rare decays $K^+ \to \pi^+ \nu \bar \nu$, $K_L \to \pi^0 \nu \bar \nu$ and $K_L \to \mu^+ \mu^-$ from new $Z^0$-penguin and box diagrams induced by the unit-charged scalars $(\tilde{\pi}^\pm, \tilde{H}^\pm, \pi_1^\pm, \pi_8^\pm)$ appeared in the Topcolor-assisted technicolor (TC2) models. We find that: (a) the unit-charged top-pion $\tilde{\pi}^\pm$ and b-pion $\tilde{H}^\pm$ can provide large contributions to the rare K-decays if they are relatively light; (b) the size of mixing elements $D_{L,R}^{ij}$ ($i \neq j$) is strongly constrained by the data of $B^0$ meson mixing: $|a_R^{ts}|, |a_R^{td}| < 0.01$ for $a_L^{td}=a_L^{ts}=1/2$ and $m_{\tilde{H}^0}\leq 600GeV$; (c) the enhancements to the branching ratios of rare K-decays from new scalars can be as large as one order of magnitude; (d) there is a strong cancellation between the short- and long-distance dispersive part of the decay $K_L \to \mu^+ \mu^-$, the constraint on the new short-distance part from this decay mode is thus not strong; (e) the typical TC2 model under study is generally consistent with the available rare K-decay data.Comment: Latex file, 27 pages and 10 ps and eps figures, to be published in Eur.Phys. J.

OR-036 Aerobic exercise activates CHI3L1/PAR2 to promote cardiomyocyte proliferation and protect cardiac function in rats with MI

Objective Objectives: The aim of this study is to investigate the changes of protein expression of chitinase-3-like protein 1 (CHI3L1) and its receptor PAR2 (protease-activated receptor 2) after exercise, and the possible mechanism to promote the proliferation of cardiomyocytes and protect MI rats heart.Methods Methods: Using rhCHI3L1 (150 ng/ml), AMPK agonists (AICAR, 50 mM) separately or together administer stimulation for 24 hours.H9C2 cells were divided into control group (H9C2 group), CHI3L1 recombinant protein intervention group (H9C2+rhCHHI3L1), AMPK agonist intervention group (H9C2+AICAR), and CHI3L1 recombinant protein and AMPK agonist combined intervention group (H9C2+rhCHI3L1+AICAR).SD rats were subjected to left anterior descending(LAD) coronary artery ligation to prepare MI models and randomly divided into sham operation group (S), myocardial infarction group (MI), myocardial infarction aerobic exercise group (ME), and injection of PAR-2 blocker agent (FSLLRY-amide) was divided into 7-day PAR2 blocker injection group (7d+FS), MI 7-day saline injection group (7d+SA), MI 14 days PAR2 blocker injection group (14d+FS), MI 14-day saline injection group (14d+SA). One week after surgery, the ME group were subjected to oneweekadaptively exercise followed by four weeks aerobic exercise.At the end of the training, the rats were intraperitoneally anesthetized the next day. Hemodynamic measurements of LVEDP, ±dp/dt max, and LVSP were used to evaluate cardiac function.The protein levels of CHI3L1/PAR2, pPI3K/PI3K, pAKT/AKT, pERK/ERK and Cyclin D1 in H9C2 and rat hearts were determined by Western blotting. The proliferation of H9C2 was detected by CCK-8. The proliferation of H9C2 and cardiac tissue was observed by immunofluorescence. Masson staining was used to observe myocardial collagen volume percent (CFV%).Results Results: Compared with H9C2 control group, the expression of CHI3L1, pPI3K/PI3K, pAKT/AKT, pERK/ERK, and Cyclin D1 protein increased significantly after rhCHI3L1 and AICAR intervention for 24 h, respectively. CCK-8 test and immunofluorescence indicated that H9C2 had significant proliferation effect. In MI rat heart, compared with MI group, the expression of CHI3L1, pPI3K/PI3K, pAKT/AKT, pERK/ERK and Cyclin D1 protein in ME group increased significantly, the number of cell proliferation increased, and LVEDP significantly decreased, ±dp/dt max, LVSP significantly increased, and the CFV% decreased significantly.Conclusions Conclusion: Exercise may promote cardiomyocyte proliferation and improve cardiac function in MI rats by activating the CHI3L1/PAR2-PI3K-AKT-ERK signaling pathway

Vortex-lattice structures in rotating Bose-Fermi superfluid mixtures

The system of Bose-Fermi superfluid mixture offers a playground to explore rich macroscopic quantum phenomena. In a recent experiment of Yao {\it et al.} [Phys. Rev. Lett. {\bf 117}, 145301 (2016)], $^{41}$K-$^{6}$Li superfluid mixture is implemented. Coupled quantized vortices are generated via rotating the superfluid mixture, and a few unconventional behaviors on the formations of vortex numbers are observed, which can be traced to boson-fermion interactions. Here we provide a theoretical insight into the unconventional behaviors observed in the experiment. To this end, the orbital-free density functional theory is hired, and its utility is validated by making comparison of numerical results and full microscopic theory for vortex lattices in strongly interacting Fermi superfluids alone. We also predict interesting phenomena which can be readily explored experimentally, including the novel structures of vortex lattices in Bose-Fermi superfluid mixtures in phase-separated regimes, and attractive interactions between vortex lines belonging to distinct superfluids.Comment: 27 pages, 9 figures, Submission to SciPost Physic

PO-163 Aerobic exercise activates myocardial FGF21/FGFR1/PI3K-AKT signaling pathway and inhibits cardiomyocyte apoptosis in post-myocardial infarction rats

Objective To investigate the effect of aerobic exercise on the expression of fibroblast growth factor 21 (FGF21) and cardiomyocyte apoptosis in Myocardial Infarction (MI) rats. Methods male SD rats were randomly divided into three groups：the sham operation (S), sedentary MI group (MI) and MI with aerobic exercise group (ME). The MI model was established by ligation of the left anterior descending branch of the left coronary artery. ME group were trained four weeks after the operation. LVSP, LVEDP and ±dp/dtmax were used to evaluate cardiac function. H9C2 cardiomyocytes were stimulated by 400 μmol/L H2O2 for 4h to simulate myocardial apoptosis mode. AMPK agonist AICAR and FGF21 receptor inhibitor PD166866 were used to interfere with H9C2. Myocardial collagen volume fraction was calculated by Masson staining and myocardium FGF21, FGFR1, Bax, Bcl-2 and PI3K-AKT pathway by western blotting or RT-Qpcr. Cardiomyocytes apoptosis was evaluated by TUNEL. Results Compared with S, the expression of FGF21, FGFR1, Bax, Bcl-2 and PI3K, AKT increased significantly in MI group, the apoptotic cardiomyocytes and collagen fibers increased significantly, but the cardiac function decreased. Compared to MI, myocardium FGF21, FGFR1 and PI3K, AKT were further increased in ME group, the Bax/Bcl-2 and the apoptotic cardiomyocytes decreased significantly. The percentage of collagen fibers decreased and the cardiac function was improved. Myocardium FGF21 was positively correlated with the inhibition of cardiomyocyte apoptosis and the improvement of cardiac function. Furthermore, the expression of Bax/Bcl-2, TNF-α/IL-10 and the apoptotic cardiomyocytes was significantly increased by PD166866, but PI3K-AKT pathway decreased significantly by PD166866. However, AICAR single intervention or PD166866 simultaneous intervention also can reverse this adverse effects. Conclusions Exercise can increase myocardial FGF21/FGFR1 with MI. The one of the mechanisms is to activate PI3K-AKT pathway to inhibit cardiaomyocyte apoptosis and inflammatory. It indicates that FGF21/FGFR1/PI3K-AKT signaling pathway plays an important role in inhibiting myocardial apoptosis and improving cardiac function

Analysis of bacterial and fungal community structure in replant strawberry rhizosphere soil with denaturing gradient gel electrophoresis

High quality DNA is the basis of analyzing bacterial and fungal community structure in replant strawberry rhizosphere soil with the method of denaturing gradient gel electrophoresis (DGGE). DNA of soil  microorganisms was extracted from the rhizosphere soil of strawberries planted in different replanted  years (0, two, six and seven), respectively, and crude DNA was purified after extraction. Three methods  were established to evaluate the effects of cetyl trimethylammonium bromide (CTAB),  polyvinylpolypyrolidone (PVPP), proteinase K and bacteriolytic enzymes on DNA extraction. DNA  fragments above 23 kb in size were isolated well by method 1 (1% CTAB, proteinase K, no PVPP, no  bacteriolytic enzyme) and method 3 (no CTAB, no proteinase K, 3% PVPP, bacteriolytic enzyme). Method 3 got the best yields 43.06 ìg/g, and A260/A280 and A260/A230 were 1.1623 and 0.8135, respectively,  which could ensure the veracity of subsequent DGGE analysis. Method 2 (3% CTAB, no proteinase K, no PVPP, no bacteriolytic enzyme) could not extract enough DNA to do the next PCR-DGGE analysis.  F341/R534 and FR1/FF390 primers were used to amplify the 16S rDNA V3 region of bacteria and 18S rDNA of fungi, and the expected fragments of 230 bp 16S rDNA V3 region and 390 bp 18S rDNA were amplified. The results of DGGE analysis showed that there were common and specific bacterial and fungal  communities in different replant soils of strawberry. There were 84 and 54% similarity of bacterial and  fungal communities between different replant soils. The numbers of both bacterial and fungal communities increased in the replant strawberry soil, they were positively correlated with the replant years. As the  number of replant years increased from two to seven years, while the ratio of bacteria/fungi was  decreased from 2.29 to 1.46 in the rhizosphere soils planted with strawberries.Key words: Rhizosphere soil, bacterial community, fungal community, replant strawberry, fruiting fields

Research Progress in Anaerobic Digestion of High Moisture

High moisture organic waste constitutes a large fraction of municipal solid waste and caused a nuisance. Anaerobic digestion of this high degradable fraction has been developed during the past 20 years. Parameters such as characteristic of substrates, temperature, organic loading rate and hydraulic retention time were studied. The most important conversion of intermediate of volatile fatty acid was observed as a indicator of digestion efficiency. One stage and two stage system are based on the stage separated into acidogenic phase and methnogenis phase. Two stage digestion of this kind of wastes were proved a better efficiency than single stage digestion. Batch system and continuous system are conducted in single stage and two-stage system. One stage system are split between wet system(Total solid less than 15%) and dry system( total solid higher than 15%) according to the characteristics of feedstock. Two-stage solid bed system are observed more and more popular in the digestion of solid state VFW and food waste experimental studies, however the large majority of industrial application use single stage systems. Two stage digestion of HMOW will be applied to industrial scale due to its larger resistance to high loading rate, high and stable gas production