83 research outputs found
Convex Optimization for Linear Query Processing under Approximate Differential Privacy
Differential privacy enables organizations to collect accurate aggregates
over sensitive data with strong, rigorous guarantees on individuals' privacy.
Previous work has found that under differential privacy, computing multiple
correlated aggregates as a batch, using an appropriate \emph{strategy}, may
yield higher accuracy than computing each of them independently. However,
finding the best strategy that maximizes result accuracy is non-trivial, as it
involves solving a complex constrained optimization program that appears to be
non-linear and non-convex. Hence, in the past much effort has been devoted in
solving this non-convex optimization program. Existing approaches include
various sophisticated heuristics and expensive numerical solutions. None of
them, however, guarantees to find the optimal solution of this optimization
problem.
This paper points out that under (, )-differential privacy,
the optimal solution of the above constrained optimization problem in search of
a suitable strategy can be found, rather surprisingly, by solving a simple and
elegant convex optimization program. Then, we propose an efficient algorithm
based on Newton's method, which we prove to always converge to the optimal
solution with linear global convergence rate and quadratic local convergence
rate. Empirical evaluations demonstrate the accuracy and efficiency of the
proposed solution.Comment: to appear in ACM SIGKDD 201
Optimizing Batch Linear Queries under Exact and Approximate Differential Privacy
Differential privacy is a promising privacy-preserving paradigm for
statistical query processing over sensitive data. It works by injecting random
noise into each query result, such that it is provably hard for the adversary
to infer the presence or absence of any individual record from the published
noisy results. The main objective in differentially private query processing is
to maximize the accuracy of the query results, while satisfying the privacy
guarantees. Previous work, notably \cite{LHR+10}, has suggested that with an
appropriate strategy, processing a batch of correlated queries as a whole
achieves considerably higher accuracy than answering them individually.
However, to our knowledge there is currently no practical solution to find such
a strategy for an arbitrary query batch; existing methods either return
strategies of poor quality (often worse than naive methods) or require
prohibitively expensive computations for even moderately large domains.
Motivated by this, we propose low-rank mechanism (LRM), the first practical
differentially private technique for answering batch linear queries with high
accuracy. LRM works for both exact (i.e., -) and approximate (i.e.,
(, )-) differential privacy definitions. We derive the
utility guarantees of LRM, and provide guidance on how to set the privacy
parameters given the user's utility expectation. Extensive experiments using
real data demonstrate that our proposed method consistently outperforms
state-of-the-art query processing solutions under differential privacy, by
large margins.Comment: ACM Transactions on Database Systems (ACM TODS). arXiv admin note:
text overlap with arXiv:1212.230
Low-Rank Mechanism: Optimizing Batch Queries under Differential Privacy
Differential privacy is a promising privacy-preserving paradigm for
statistical query processing over sensitive data. It works by injecting random
noise into each query result, such that it is provably hard for the adversary
to infer the presence or absence of any individual record from the published
noisy results. The main objective in differentially private query processing is
to maximize the accuracy of the query results, while satisfying the privacy
guarantees. Previous work, notably the matrix mechanism, has suggested that
processing a batch of correlated queries as a whole can potentially achieve
considerable accuracy gains, compared to answering them individually. However,
as we point out in this paper, the matrix mechanism is mainly of theoretical
interest; in particular, several inherent problems in its design limit its
accuracy in practice, which almost never exceeds that of naive methods. In
fact, we are not aware of any existing solution that can effectively optimize a
query batch under differential privacy. Motivated by this, we propose the
Low-Rank Mechanism (LRM), the first practical differentially private technique
for answering batch queries with high accuracy, based on a low rank
approximation of the workload matrix. We prove that the accuracy provided by
LRM is close to the theoretical lower bound for any mechanism to answer a batch
of queries under differential privacy. Extensive experiments using real data
demonstrate that LRM consistently outperforms state-of-the-art query processing
solutions under differential privacy, by large margins.Comment: VLDB201
Novel compounds in fruits of coriander (Coşkuner & Karababa) with anti-inflammatory activity
© 2020 Coriander, Coriandrum Sativum L., is one of the commonest food and medicinal plants in many countries, but its chemical ingredients and pivotal role in anti-inflammatory activity have not been fully explored. The present study aimed to identify new compounds in the fruits of coriander and explore their anti-inflammatory activity. The compounds were isolated by chromatographic seperations and identified using spectroscopic and spectrometric methods. RAW264.7 macrophage cells were used to detect the anti-inflammatory activity of the compounds via Griess assay, western blotting, ELISA, and flow cytometry methods. The study resulted in the discovery of four new compounds, which were identified as: 4α-(furo[2,3-d]pyrimidin-6′-ylmethyl)-9α-propylnonolactone (1), 4-(formyloxy)-4-(6′-methylcyclohex-1-en-1-yl)butanoate(2), (7α,8α)-3α-hydroxyl-12,13α-dimethyl-5(6)-en-bicyclo[5,3,0]caprolactone (3), 7-methoxy-4-methyl-5,6-dihydro-7H-(2-hydroxypropan-2-yl)furo[2,3-f] coumarin (4). Compound 3 showed the highest anti-inflammatory activity with IC50 of 6.25 μM for an inhibitory effect on nitrite oxide (NO) level. In addition, compound 3 decreased the lipopolysaccharides-stimulated generations of ROS and the inflammatory cytokines (IL-6 and TNF-α). Mechanism exploration indicated that compound 3 suppressed inflammatory mediators’ expression, like iNOS and COX-2. Furthermore, the NF-κB and MAPK pathways were involved in the anti-inflammatory process of compound 3
Few-photon single ionization of cold rubidium in the over-the-barrier regime
Photoionization of the rubidium (Rb) atoms cooled in a magneto-optical trap,
characterized by the coexistence of the ground 5 and the excited
5 states, is investigated experimentally and theoretically with the
400 nm femtosecond laser pulses at intensities of W/cm -
W/cm. Recoil-ion momentum distribution (RIMD) of Rb
exhibits rich ring-like structures and their energies correspond to one-photon
ionization of the 5 state, two-photon and three-photon ionizations of
the 5 state, respectively. With the increasing of , we find that
experimental signals near zero-momentum (NZM) in RIMDs resulted from the
5 state enhance dramatically and its peaked Rb momenta dwindle
obviously while that from the 5 state is maintained. Meanwhile, the
ion-yield ratio of the 5 over the 5 states varies from to
as increases. These features indicate a transition from
perturbative ionization to strong-perturbative ionization for the 5
state. Numerical simulations by solving the time-dependent Schr\"odinger
equation (TDSE) can qualitatively explain the measurements of RIMD, photoion
angular distributions, as well as ion-yield ratio. However, some discrepancies
still exist, especially for the NZM dip, which could stem from the
electron-electron correlation that is neglected in the present TDSE simulations
since we have adopted the single-active-electron approximation
Ellipticity-dependent sequential over-barrier ionization of cold rubidium
We perform high-resolution measurements of momentum distribution on Rb
recoil ions up to charge state , where laser-cooled rubidium atoms are
ionized by femtosecond elliptically polarized lasers with the pulse duration of
35 fs and the intensity of 3.310 W/cm in the over-barrier
ionization (OBI) regime. The momentum distributions of the recoil ions are
found to exhibit multi-band structures as the ellipticity varies from the
linear to circular polarizations. The origin of these band structures can be
explained quantitatively by the classical OBI model and dedicated classical
trajectory Monte Carlo simulations with Heisenberg potential. Specifically,
with back analysis of the classical trajectories, we reveal the ionization time
and the OBI geometry of the sequentially released electrons, disentangling the
mechanisms behind the tilted angle of the band structures. These results
indicate that the classical treatment can describe the strong-field multiple
ionization processes of alkali atoms
Deconstructing Survivin: comprehensive genetic analysis of Survivin function by conditional knockout in a vertebrate cell line
Survivin is a key cellular protein thought to function in apoptotic regulation, mitotic progression, or possibly both. In this study, we describe the isolation of two conditional knockouts of the survivin gene in chicken DT40 cells. DT40 cells lacking Survivin die in interphase after failing to complete cytokinesis. However, these cells show normal sensitivity to the chemotherapeutic agent etoposide. Expression of Survivin mutants against a null background to reassess the role of several key residues reveals that DT40 cells can grow normally if their sole Survivin is missing a widely studied cyclin-dependent kinase phosphorylation site or sites reportedly essential for binding to Smac or aurora B. Mutations in the nuclear export sequence or dimerization interface render cells temperature sensitive for growth. As an important caveat for other studies in which protein function is studied by transient transfection, three of the Survivin mutants fail to localize in the presence of the wild-type protein but do localize and indeed support life in its absence
Multifunctional nanoparticle-VEGF modification for tissue-engineered vascular graft to promote sustained anti-thrombosis and rapid endothelialization
Purpose: The absence of a complete endothelial cell layer is a well-recognized reason leading to small-diameter tissue-engineered vascular graft failure. Here we reported a multifunctional system consisting of chitosan (CS), Arg-Glu-Asp-Val (REDV) peptide, heparin, and vascular endothelial growth factor (VEGF) to achieve sustained anti-thrombosis and rapid endothelialization for decellularized and photo-oxidized bovine internal mammary arteries (DP-BIMA).Methods: CS-REDV copolymers were synthesized via a transglutaminase (TGase) catalyzed reaction. CS-REDV-Hep nanoparticles were formed by electrostatic self-assembly and loaded on the DP-BIMA. The quantification of released heparin and vascular endothelial growth factor was detected. Hemolysis rate, platelets adhesion, endothelial cell (EC) adhesion and proliferation, and MTT assay were performed in vitro. The grafts were then tested in a rabbit abdominal aorta interposition model for 3 months. The patency rates were calculated and the ECs regeneration was investigated by immunofluorescence staining of CD31, CD144, and eNOS antibodies.Results: The nanoparticle-VEGF system (particle size: 61.8 ± 18.3 nm, zeta-potential: +13.2 mV, PDI: .108) showed a sustained and controlled release of heparin and VEGF for as long as 1 month and exhibited good biocompatibility, a lower affinity for platelets, and a higher affinity for ECs in vitro. The nanoparticle-VEGF immobilized BIMA achieved 100% and 83.3% patency in a rabbit abdominal interposition model during 1 and 3 months, respectively, without any thrombogenicity and showed CD31, CD144, eNOS positive cell adhesion as early as 1 day. After 3 months, CD31, CD144, and eNOS positive cells covered almost the whole luminal surface of the grafts.Conclusion: The results demonstrated that the multifunctional nanoparticle-VEGF system can enhance the anti-thrombosis property and promote rapid endothelialization of small-diameter tissue-engineered vascular grafts. Utilizing nanoparticles to combine different kinds of biomolecules is an appropriate technology to improve the long-term patency of small-diameter tissue-engineered vascular grafts
The Role of PTHLH in Ovarian Follicle Selection, Its Transcriptional Regulation and Genetic Effects on Egg Laying Traits in Hens
In hens, follicle selection is an important process affecting egg laying traits. This study investigated the role of parathyroid hormone-like hormone (PTHLH) in chicken follicle selection, its transcriptional regulation and genetic effects on egg laying traits. PTHLH and its receptor PTH1R were mainly expressed in follicles of 6–8 mm in diameter, exhibits differential expression pattern in the theca and granulosa cells of pre- and hierarchal follicles. PTHLH stimulates the proliferation of follicular granulosa and theca cells, the expression of StAR and CYP11A1 mRNA and the production of progesterone (P4) in pre-hierarchal follicles. Treatment with FSH increased PTHLH mRNA expression in pre-hierarchal follicular theca cells and hierarchal follicular granulosa cells. Two critical regions regulating chicken PTHLH transcription were revealed, each of which harbored a SNP: C>T (chr1: 72530014) for AP-1 and a SNP: A>G (chr1: 72531676). Hens with diplotype AC/GT were younger at first laying and laid more eggs at 32 weeks. The haplotype (G-1827T-165) with double mutations had the greatest promoter activity of chicken PTHLH transcription. Collectively, PTHLH plays an important role in chicken follicle selection by stimulating cell proliferation and steroidogenesis. Polymorphisms in chicken PTHLH promoter region are associated with egg laying traits by affecting the binding of transcription factor AP-1
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