169 research outputs found
Exploration or Exploitation?The Impact of Empowering Leadership on Ambidextrous Innovations for Medium-Sized Enterprises in China: The Moderating Role of Managerial Ties
The study focuses on the impact of empowering leadership on the ambidextrous innovation of SMEs in emerging economies. There are two types of definitions for ambidextrous innovation on the strategic perspective, balance and trade-off. In this article, we only discuss trade-off for the ambidextrous innovation of enterprises. On the one hand, we studied the influence mechanism of the empowering leadership behavior of SMEs on the ambidextrous innovation of SMEs in emerging economies, with the sample in China. On the other hand, the paper also reveals the role of managerial ties of leaders on the empowering leadership and ambidextrous innovation. Through the questionnaire survey and data analysis, we concluded that the leader’s managerial ties could moderate the relationship between the empowering leadership and the SMEs' ambidextrous innovation willingness. The conclusions of this study provide a reference for the further development and reform of SMEs in China and other emerging economies. Keywords: SME; Empowering leadership; Ambidextrous innovation; Managerial Ties DOI: 10.7176/EJBM/11-16-05 Publication date:June 30th 201
A fast tunable driver of light source for the TRIDENT Pathfinder experiment
TRIDENT (The tRopIcal DEep-sea Neutrino Telescope) is a proposed
next-generation neutrino telescope to be constructed in the South China Sea. In
September 2021, the TRIDENT Pathfinder experiment (TRIDENT EXplorer, T-REX for
short) was conducted to evaluate the in-situ optical properties of seawater.
The T-REX experiment deployed three digital optical modules at a depth of 3420
meters, including a light emitter module (LEM) and two light receiver modules
(LRMs) equipped with photomultiplier tubes (PMTs) and cameras to detect light
signals. The LEM emits light in pulsing and steady modes. It features a fast
tunable driver to activate light-emitting diodes (LEDs) that emit
nanosecond-width light pulses with tunable intensity. The PMTs in the LRM
receive single photo-electron (SPE) signals with an average photon number of
approximately 0.3 per 1-microsecond time window, which is used to measure the
arrival time distribution of the SPE signals. The fast tunable driver can be
remotely controlled in real-time by the data acquisition system onboard the
research vessel, allowing for convenient adjustments to the driver's parameters
and facilitating the acquisition of high-quality experimental data. This paper
describes the requirements, design scheme, and test results of the fast tunable
driver, highlighting its successful implementation in the T-REX experiment and
its potential for future deep-sea experiments
Metabolic regulation by biomaterials in osteoblast
The repair of bone defects resulting from high-energy trauma, infection, or pathological fracture remains a challenge in the field of medicine. The development of biomaterials involved in the metabolic regulation provides a promising solution to this problem and has emerged as a prominent research area in regenerative engineering. While recent research on cell metabolism has advanced our knowledge of metabolic regulation in bone regeneration, the extent to which materials affect intracellular metabolic remains unclear. This review provides a detailed discussion of the mechanisms of bone regeneration, an overview of metabolic regulation in bone regeneration in osteoblasts and biomaterials involved in the metabolic regulation for bone regeneration. Furthermore, it introduces how materials, such as promoting favorable physicochemical characteristics (e.g., bioactivity, appropriate porosity, and superior mechanical properties), incorporating external stimuli (e.g., photothermal, electrical, and magnetic stimulation), and delivering metabolic regulators (e.g., metal ions, bioactive molecules like drugs and peptides, and regulatory metabolites such as alpha ketoglutarate), can affect cell metabolism and lead to changes of cell state. Considering the growing interests in cell metabolic regulation, advanced materials have the potential to help a larger population in overcoming bone defects
A Scorpion Defensin BmKDfsin4 Inhibits Hepatitis B Virus Replication in Vitro
Hepatitis B virus (HBV) infection is a major worldwide health problem which can cause
acute and chronic hepatitis and can significantly increase the risk of liver cirrhosis and primary
hepatocellular carcinoma (HCC). Nowadays, clinical therapies of HBV infection still mainly rely on
nucleotide analogs and interferons, the usage of which is limited by drug-resistant mutation or side
effects. Defensins had been reported to effectively inhibit the proliferation of bacteria, fungi, parasites
and viruses. Here, we screened the anti-HBV activity of 25 scorpion-derived peptides most recently
characterized by our group. Through evaluating anti-HBV activity and cytotoxicity, we found that
BmKDfsin4, a scorpion defensin with antibacterial and Kv1.3-blocking activities, has a comparable
high inhibitory rate of both HBeAg and HBsAg in HepG2.2.15 culture medium and low cytotoxicity
to HepG2.2.15. Then, our experimental results further showed that BmKDfsin4 can dose-dependently
decrease the production of HBV DNA and HBV viral proteins in both culture medium and cell lysate.
Interestingly, BmKDfsin4 exerted high serum stability. Together, this study indicates that the scorpion
defensin BmKDfsin4 also has inhibitory activity against HBV replication along with its antibacterial
and potassium ion channel Kv1.3-blocking activities, which shows that BmKDfsin4 is a uniquely
multifunctional defensin molecule. Our work also provides a good molecule material which will be
used to investigate the link or relationship of its antiviral, antibacterial and ion channel–modulating
activities in the future
Water entry of slender segmented projectile connected by spring
An object that enters the water experiences a large impact acceleration at the initial stage of water entry, which can cause structural damage to objects that are dropped or launched into the water. To reduce the peak impact acceleration, a spring-connected segmented projectile with compressible nose was designed. Through inertial measurement unit and high-speed camera, the influence of the nose compressibility on the initial impact acceleration was qualitatively investigated. The experimental results demonstrate that the introduction of a spring between the nose and the main body of the projectile can significantly suppresses the peak acceleration during the early stage of impact (0–50 ms). Furthermore, the maximum impact acceleration experienced by the main body is only related to the maximum compression of the nose without considering the spring stiffness. In addition, using the spring exerts a slight effect on the non-dimensional pinch-off times of the cavity but increases the initial velocity required for the occurrence of cavity pinch-off events on the side of the main bod
Home appliances classification based on multi-feature using ELM
With the development of science and technology, the application in artificial intelligence has been more and more popular, as well as smart home has become a hot topic. And pattern recognition adapting to smart home attracts more attention, while the improvement of the accuracy of recognition is an important and difficult issue of smart home. In this paper, the characteristics of electrical appliances are extracted from the load curve of household appliances, and a fast and efficient home appliance recognition algorithm is proposed based on the advantage of classification of ELM (Extreme Learning Machine). At the same time, the sampling frequency with low rate is mentioned in this paper, which can obtain the required data through intelligent hardware directly, as well as reduce the cost of investment. And the intelligent hardware isdesigned by our team, which is wireless sensor network (WSN) composed by a lot of wireless sensors. Experiments in this paper show that the proposed method can accurately determine theusing electrical appliances. And greatly improve the accuracy of identification, which can further improve the popularity of smart home
Dynamics and hydrodynamic efficiency of diving beetle while swimming
Diving beetle, an excellent biological prototype for bionic underwater vehicles, can achieve forward swimming, backward swimming, and flexible cornering by swinging its two powerful hind legs. An in-depth study of the propulsion performance of them will contribute to the micro underwater vehicles. In this paper, the kinematic and dynamic parameters, and the hydrodynamic efficiency of the diving beetle are studied by analysis of swimming videos using Motion Capture Technology, combined with CFD simulations. The results show that the hind legs of diving beetle can achieve high propulsion force and low return resistance during one propulsion cycle at both forward and backward swimming modes. The propulsion efficiencies of forward and backward swimming are 0.47 and 0.30, respectively. Although the efficiency of backward swimming is lower, the diving beetle can reach a higher speed in a short time at this mode, which can help it avoid natural enemies. At backward swimming mode, there is a long period of passive swing of hind legs, larger drag exists at higher speed during the recovery stroke, which reduces the propulsion efficiency to a certain extent. Reasonable planning of the swing speed of the hind legs during the power stroke and the recovery stroke can obtain the highest propulsion efficiency of this propulsion method. This work will be useful for the development of a bionic propulsion system of micro underwater vehicle
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