N4 DNA recognition by STAT6: structural and functional implications

On Nov. 1st 2016,a research paper titled Structural basis for DNA recognition by STAT6 was published online on PNAS(Li et al., 2016), which revealed for the first time the mechanism of signal transducer and activator of transcription 6(STAT6) recognition by DNA with N4 site. The authors are from the Institute of Biophysics, Chinese Academy of Sciences (CAS).National Natural Science Foundation of China [91129000]; Peking-Tsinghua Center for Life SciencesSCI(E)中国科学引文数据库(CSCD)EDITORIAL MATERIAL4240-241

Accelerated progression of Hodgkin\u27s-like lymphomas in golli deficient SJL mice

Spontaneously occurring lymphomas in SJL mice have many pathological features similar to Hodgkin\u27s lymphoma in humans. The malignant growth of the tumor cells is dependent on the support of host FoxP3(+)CD4(+) regulatory T cells (Tregs). In this study, we report that the ablation of golli protein, a negative regulator of CRAC (calcium release activated calcium) channel, in SJL mice results in an accelerated progression of Hodgkin\u27s-like lymphoma which is accompanied by a facilitated conversion of FoxP3(+) Treg cells. Our results suggest that golli protein might affect the progression of Hodgkin\u27s-like lymphomas through regulating the induction of Treg cells

Animal-Protein-Based and Synthetic-Based Foamed Mixture Lightweight Soil Doped with Bauxite Tailings: Macro and Microscopic Properties

In order to explore the effect of the foaming agent type on the properties of foamed mixture lightweight soil mixed with bauxite tailings (FMLSB), low-density (437.5 kg/m3 and 670 kg/m3) and high-density (902.5 kg/m3 and 1170 kg/m3) FMLSB were prepared using protein-based and synthetic-based foaming agents (AF and SF, respectively). The foam stability, micro characteristics, compressive strength, fluidity, and volume of water absorption of the FMLSB were investigated. The results showed that the foam made from AF had better strength and stability compared to SF. The internal pore sizes of both AF- and SF-FMLSB at low density were large, but at high density the internal pore sizes and area porosity of AF-FMLSB were smaller than those of SF-FMLSB. In terms of compressive strength, the compressive strength of AF-FMLSB was improved by 17.5% to 43.2% compared to SF-FMLSB. At low density, the fluidity of AF- and SF-FMLSB is similar, while at high density the fluidity of AF-FMLSB is much higher than that of SF-FMLSB. In addition, the stable volume of water absorption of SF-FMLSB is smaller than that of AF-FMLSB at low density, and the corresponding water resistance is better, but the situation is reversed at high density