63 research outputs found
Improved Neural Radiance Fields Using Pseudo-depth and Fusion
Since the advent of Neural Radiance Fields, novel view synthesis has received
tremendous attention. The existing approach for the generalization of radiance
field reconstruction primarily constructs an encoding volume from nearby source
images as additional inputs. However, these approaches cannot efficiently
encode the geometric information of real scenes with various scale
objects/structures. In this work, we propose constructing multi-scale encoding
volumes and providing multi-scale geometry information to NeRF models. To make
the constructed volumes as close as possible to the surfaces of objects in the
scene and the rendered depth more accurate, we propose to perform depth
prediction and radiance field reconstruction simultaneously. The predicted
depth map will be used to supervise the rendered depth, narrow the depth range,
and guide points sampling. Finally, the geometric information contained in
point volume features may be inaccurate due to occlusion, lighting, etc. To
this end, we propose enhancing the point volume feature from depth-guided
neighbor feature fusion. Experiments demonstrate the superior performance of
our method in both novel view synthesis and dense geometry modeling without
per-scene optimization
Carboxymethyl chitosan-folic acid-conjugated Fe3O4@SiO2 as a safe and targeting antitumor nanovehicle in vitro
A synthetic method to prepare a core-shell-structured Fe(3)O(4)@SiO(2) as a safe nanovehicle for tumor cell targeting has been developed. Superparamagnetic iron oxide is encapsulated inside nonporous silica as the core to provide magnetic targeting. Carboxymethyl chitosan-folic acid (OCMCS-FA) synthesized through coupling folic acid (FA) with OCMCS is then covalently linked to the silica shell and renders new and improved functions because of the original biocompatible properties of OCMCS and the targeting efficacy of FA. Cellular uptake of the nanovehicle was assayed by confocal laser scanning microscope using rhodamine B (RB) as a fluorescent marker in HeLa cells. The results show that the surface modification of the core-shell silica nanovehicle with OCMCS-FA enhances the internalization of nanovehicle to HeLa cells which over-express the folate receptor. The cell viability assay demonstrated that Fe(3)O(4)@SiO(2)-OCMCS-FA nanovehicle has low toxicity and can be used as an eligible candidate for drug delivery system. These unique advantages make the prepared core-shell nanovehicle promising for cancer-specific targeting and therapy
Combustion reactivity of ilmenite with coal volatiles under steam gasification atmosphere
学位記番号:理工博甲6
Comparative Ecophysiological Study of Salt Stress for Wild and Cultivated Soybean Species from the Yellow River Delta, China
Delivery Efficiency of miR-21i-CPP-SWCNT and Its Inhibitory Effect on Fibrosis of the Renal Mesangial Cells
MicroRNA 21 (miR-21) was proved to cause renal fibrosis and the inhibition of miR-21 would improve the poor prognosis in renal cell carcinoma diseases. The complementary oligonucleotide of mature miR-21 was considered to be an effective intracellular miR-21 inhibitor (miR-21i). The directly effective delivery of miR-21i into fibrotic cell is a facile method for treatment of renal fibrosis. Herein, the miR-21i-CPP-SWCNT delivery system, synthesized via single-walled carbon nanotube (SWCNT) and cell-penetrating peptide (CPP), was taken as a novel fibrosis-targeting therapeutic carrier. The miR-21i and CPP firstly bind together via electrostatic forces, and subsequently miR-21i-CPP binds to the surface of SWCNTs via hydrophobic forces. CPP could endow the delivery system with targeting property, while SWCNT would enhance its penetrating ability. The exogenous miR-21i released from the designed miR-21i-CPP-SWCNTs had successfully inhibited the expression of fibrosis-related proteins in renal mesangial cells (RMCs). We found that the expression of TGF-β1 proteins was more sensitive to miR-21i-CPP-SWCNT than the expression of α-SMA proteins
Short-interval second ejaculation improves sperm quality, blastocyst formation in oligoasthenozoospermic males in ICSI cycles: a time-lapse sibling oocytes study
BackgroundDoes short-interval second ejaculation improve sperm quality, embryo development and clinical outcomes for oligoasthenozoospermia males received intracytoplasmic sperm injection (ICSI) treatment?MethodsAll enrolled male patients underwent short-interval secondary ejaculation on the day of oocyte retrieval, and 786 sibling MII oocytes from 67 cycles were equally divided into two groups based on whether the injected spermatozoons originated from the first or second ejaculation. Semen parameters, embryo development efficiency, morphokinetic parameters and clinical outcomes were compared between the two groups to assess the efficiency and clinical value of short-interval second ejaculation in ICSI cycles.ResultsShort-interval second ejaculation significantly improved sperm motility, normal morphological rate, and sperm DNA integrity both before and after sperm swim-up. The high-quality blastocyst rate (24.79% versus 14.67%), available blastocyst rate (57.56% versus 48.44%), and oocyte utilization rate (52.93% versus 45.29%) were significantly higher in the second ejaculation group (P<0.05). The clinical pregnancy rate (59.09% versus 47.37%), implantation rate (42.11% versus 32.35%) and live birth rate (40.91% versus 31.58%) were higher in the second ejaculation group, but the differences were not significant (P>0.05). Time-lapse analysis showed that morphokinetic time points after the 7-cell stage were earlier in the second ejaculation group but without a significant difference (P>0.05), and abnormal embryo cleavage patterns between the two groups were not significantly different (P>0.05).ConclusionsShort-interval second ejaculation significantly improves sperm quality in oligoasthenozoospermic males, and is beneficial for blastocyst formation efficiency in ICSI cycles. This study suggested a non-invasive and simple but effective strategy for improving ICSI treatment outcomes
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Size uniformity of animal cells is actively maintained by a p38 MAPK-dependent regulation of G1-length
Animal cells within a tissue typically display a striking regularity in their size. To date, the molecular mechanisms that control this uniformity are still unknown. We have previously shown that size uniformity in animal cells is promoted, in part, by size-dependent regulation of G1 length. To identify the molecular mechanisms underlying this process, we performed a large-scale small molecule screen and found that the p38 MAPK pathway is involved in coordinating cell size and cell cycle progression. Small cells display higher p38 activity and spend more time in G1 than larger cells. Inhibition of p38 MAPK leads to loss of the compensatory G1 length extension in small cells, resulting in faster proliferation, smaller cell size and increased size heterogeneity. We propose a model wherein the p38 pathway responds to changes in cell size and regulates G1 exit accordingly, to increase cell size uniformity
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Urban signals in high-resolution weather and climate simulations: role of urban land-surface characterisation
Two urban schemes within the Joint UK Land Environment Simulator
(JULES) are evaluated offline against multi-year flux observations in the densely
built-up city centre of London and in suburban Swindon (UK): (i) the 1-tile slab
model, used in climate simulations, (ii) the 2-tile canopy model MORUSES (Met
Office–Reading Urban Surface Exchange Scheme), used for numerical weather pre-
diction over the UK. Offline, both models perform better at the suburban site,
where differences between the urban schemes are less pronounced due to larger
vegetation fractions. At both sites, the outgoing short- and longwave radiation is
more accurately represented than the turbulent heat fluxes. The seasonal varia-
tions of model skill are large in London, where the sensible heat flux in autumn and
winter is strongly under-predicted if the large city-centre magnitudes of anthro-
pogenic heat emissions are not represented. The delayed timing of the sensible heat flux in the 1-tile model in London results in large negative bias in the morning.
The partitioning of the urban surface into canyon and roof in MORUSES improves
this as the roof-tile is modelled with a very low thermal inertia, but phase and
amplitude of the gridbox-averaged flux critically depend on accurate knowledge of
the plan-area fractions of streets and buildings. Not representing non-urban land-
cover (e.g. vegetation, inland water) in London results in severely under-predicted
latent heat fluxes. Control runs demonstrate that the skill of both models can be
greatly improved by providing accurate land-cover and morphology information
and using representative anthropogenic heat emissions, which is essential if the
model output is intended to inform integrated urban services
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