3 research outputs found
Lewis Acid-Catalyzed Cyclization of Enaminones with Propargylic Alcohols: Regioselective Synthesis of Multisubstituted 1,2-Dihydropyridines
A highly
efficient BF<sub>3</sub>·Et<sub>2</sub>O-catalyzed cascade reaction
of enaminones with propargylic alcohols under mild reaction conditions
has been developed. This methodology offers regioselective access
to multisubstituted 1,2-dihydropyridines in good to excellent yields
Lewis Acid-Catalyzed Cyclization of Enaminones with Propargylic Alcohols: Regioselective Synthesis of Multisubstituted 1,2-Dihydropyridines
A highly
efficient BF<sub>3</sub>·Et<sub>2</sub>O-catalyzed cascade reaction
of enaminones with propargylic alcohols under mild reaction conditions
has been developed. This methodology offers regioselective access
to multisubstituted 1,2-dihydropyridines in good to excellent yields
Metal/Benzoyl Peroxide (BPO)-Controlled Chemoselective Cycloisomerization of (<i>o</i>‑Alkynyl)phenyl Enaminones: Synthesis of α‑Naphthylamines and Indeno[1,2‑<i>c</i>]pyrrolones
Synthetic
methods involving chemoselective tandem reactions for
the synthesis of α-naphthylamines and indeno[1,2-<i>c</i>]pyrrolones starting from (<i>o</i>-aklynyl)phenyl
enaminones are described. When reactions were carried out in <i>N,N</i>-dimethylformamide (DMF) using a AgNO<sub>3</sub> catalyst, α-naphthylamines were obtained in up to 89% isolated
yields within 2 h. Whereas indeno[1,2-<i>c</i>]pyrrolones
were produced in high isolated yields in the presence of benzoyl peroxide
(BPO) and CuCl catalysis