Experimental investigation of the effects of drilling fluid activity on the hydration behavior of shale reservoirs in Northwestern Hunan, China

The interaction between drilling fluid and shale has a significant impact on wellbore stability during shale oil and gas drilling operations. This paper investigates the effects of the drilling fluid activity on the surface and osmotic hydration characteristics of shale. Experiments were conducted to measure the influence of drilling fluid activity on surface wettability by monitoring the evolution of fluid-shale contact angles. The relationship between drilling fluid activity and shale swelling ratio was determined to investigate the osmotic hydration behavior. The results indicate that, with increasing drilling fluid activity, the fluid–shale contact angles gradually increase—the higher the activity, the faster the adsorption rate; and the stronger the inhibition ability, the weaker the surface hydration action. The surface adsorption rate of the shale with a KCl drilling fluid was found to be the highest. Regarding the osmotic hydration action on the shale, the negative extreme swelling ratio (b) of the shale was found to be: bKCl \u3c bCTAB \u3c bSDBS. Moreover, based on the relationship between the shale swelling ratio and drilling fluid activity, shale hydration can be divided into complete dehydration, weak dehydration, surface hydration, and osmotic hydration, which contributes to the choice of drilling fluids to improve wellbore stability

Experimental treatment of radiation pneumonitis with human umbilical cord mesenchymal stem cells

AbstractObjectiveTo evaluate of the curative effect of human umbilical cord mesenchymal stem cells (hUC-MSCs) on rat acute radiation pneumonitis.MethodsFourty rats were randomly divided into control group, radiation group, stem cell prevention group, stem cell treatment group and prednisone treatment group. All rats except those in the control group were radiated with X ray to establish the acute radiation pneumonitis damage model. The hUC-MSCs cultured in vitro was administrated to the rats of the prevention group via tail vein (1×106 cells/kg BW) 24 h before the radiation, while the same administration was performed in the rats of the treatment group 24 h after the radiation. After 24 h post the radiation, the rats in the radiation group were given 0.4 mL physiological saline, and those in the prednisone group were given 1 mg/kg prednisone. All rats were observed and executed 72 h after the radiation to detect lung histological changes.ResultsAfter the administration of hUC-MSCs, the survival status of the rats in the prevention group and treatment group was obviously better than that in the control group. As shown by the histological staining, the morphology, proliferation activity and bronchial state of lung tissues were better in the prevention group and treatment group than in the control group.ConclusionsThe hUC-MSCs have definite therapeutic effects on acute radiation pneumonitis in rats

Attacking practical quantum key distribution system with wavelength dependent beam splitter and multi-wavelength sources

Unconditional security of quantum key distribution protocol can be guaranteed by the basic property of quantum mechanics. Unfortunately, the practical quantum key distribution system always have some imperfections, and the practical system may be attacked if the imperfection can be controlled by the eavesdropper Eve. Applying the fatal security loophole introduced by the imperfect beam splitter's wavelength dependent optical property, we propose wavelength-dependent attacking model, which can be applied to almost all practical quantum key distribution systems with the passive state modulation and photon state detection after the practical beam splitter. Utilizing our attacking model, we experimentally demonstrate the attacking system based on practical polarization encoding quantum key distribution system with almost 100% success probability. Our result demonstrate that all practical devices require tightened security inspection for avoiding side channel attacks in practical quantum key distribution experimental realizations

Danshensu for Myocardial Ischemic Injury: Preclinical Evidence and Novel Methodology of Quality Assessment Tool

Background: Danshensu (DSS) possesses unique bioactivity on the cardiovascular system. However, there is a lack of systematical summary of DSS for acute myocardial ischemia injury and no quality assessment tool for the systematical review of cell experiments. Here, we aimed to assess the preclinical evidences and possible mechanisms of DSS for myocardial ischemia injury, and to develop a quality assessment tool for the systematical review of cell experiments.Methods: Thirty-two studies with 473 animals and 134 cells were identified by searching seven databases. All data analysis was performed using RevMan 5.3. CAMARADES 10-item checklist was used to assess the methodological quality of animal experiments. A new 10-item checklist was first developed to assess the methodological quality of cell studies.Results: The score of study quality ranged from 3 to 7 points in animal studies, while the cell studies scored 3–6 points. Meta-analysis showed that DSS had significant effects on reducing myocardial infarct (MI) size in vivo, and increasing cell viability and reducing apoptosis rate in vitro compared with controls (P < 0.01). The possible mechanisms of DSS for MI are improving circulation, antioxidant, anti-apoptosis, anti-inflammatory, promoting angiogenesis, anti-excessive autophagy, anti-calcium overload, and improving energy metabolism.Conclusions: DSS could exert cardioprotective effect on myocardial ischemia injury, and thus is a probable candidate for further clinical trials andtreatment of AMI. In addition, the newly devloped 10-item checklist for assessing methodological quality of cell study that recommened to use the sysmatic review of cell studies

1H-Imidazol-3-ium-4-carboxyl­ate

In the title compound, C4H4N2O2, both imidazole N atoms are protonated and carboxyl­ate group is deprotonated, resulting in a zwitterion. The mol­ecule is essentially planar, with an r.m.s. deviation of 0.012 (1) Å. In the crystal, N—H⋯O hydrogen bonds and π–π stacking inter­actions [centroid–centroid distance = 3.674 (2) Å] between the imidazole rings link the mol­ecules into a three-dimensional supra­molecular network