A substitution-dependent light-up fluorescence probe for selectively detecting Fe3+ ions and its cell imaging application

Deliberate design of specific and sensitive molecular probes with distinctive physical/chemical properties for analyte sensing is of great significance. Herein, by taking advantage of the position-dependent substituent effects, an aggregation-induced emission featured iron (III) probe from ortho-substituted pyridinyl-functionalized tetraphenylethylene (TPE-o-Py) is synthesized. It displays high sensitivity and selectivity toward iron (III) detection. The recognition arises from the position isomer of ortho-substitution, and the fact that TPE-o-Py has a low acid dissociation constant (pKa) that is close to that of hydrolyzed Fe3+. Importantly, TPE-o-Py as a light-up fluorescence probe could be employed for Fe3+sensing in living cells with a pronounced red-shift in fluorescence emission

Comparison of <i>PPI</i> with different topologies and <i>ξ</i>.

<p>Comparison of <i>PPI</i> with different topologies and <i>ξ</i>.</p

Reduction rate of number of running servers when encouragement function is used with different <i>w</i>_<i>s</i>.

<p>Reduction rate of number of running servers when encouragement function is used with different <i>w</i>_<i>s</i>.</p

FlowMover framework.

<p>FlowMover framework.</p

Optimization of network traffic cost by SCM.

<p>(a) <i>w</i>_<i>s</i> = 5, (b) <i>w</i>_<i>s</i> = 10, (c) <i>w</i>_<i>s</i> = 15.</p

Comparison of time cost between SA with recursive traversal and random sampling algorithm.

<p>Comparison of time cost between SA with recursive traversal and random sampling algorithm.</p

A scenario for reducing energy consumption.

<p>A scenario for reducing energy consumption.</p

Comparison of <i>PPI</i> using recursive traversal and random sampling algorithm.

<p>Comparison of <i>PPI</i> using recursive traversal and random sampling algorithm.</p

The penetration topology deployed with decoy chains.

<p>The penetration topology deployed with decoy chains.</p

Abbreviations.

<p>Abbreviations.</p