Effect of Granulocyte-Colony Stimulating Factor on Endothelial Cells and Osteoblasts

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Effect of Ovariectomy on Stimulating Intracortical Remodeling in Rats

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Globular adiponectin, acting via AdipoR1/APPL1, protects H9c2 cells from hypoxia/reoxygenation-induced apoptosis

Cardiomyocyte apoptosis is an important remodeling event contributing to heart failure and adiponectin may mediate cardioprotective effects at least in part via attenuating apoptosis. Here we used hypoxia-reoxygenation (H/R) induced apoptosis in H9c2 cells to examine the effect of adiponectin and cellular mechanisms of action. We first used TUNEL labeling in combination with laser scanning cytometry to demonstrate that adiponectin prevented H/R-induced DNA fragmentation. The anti-apoptotic effect of adiponectin was also verified via attenuation of H/R-induced phosphatidylserine exposure using annexin V binding. H/R-induced apoptosis via the mitochondrial-mediated intrinsic pathway of apoptosis as assessed by cytochrome c release into cytosol and caspase-3 activation, both of which were attenuated by adiponectin. Mechanistically, we demonstrated that adiponectin enhanced anti-oxidative potential in these cells which led to attenuation of the increase in intracellular reactive oxygen species (ROS) caused by H/R. To further address the mechanism of adiponctins anti-apoptotic effects we used siRNA to efficiently knockdown adiponectin receptor (AdipoR1) expression and found that this attenuated the protective effects of adiponectin on ROS production and caspase 3 activity. Knockdown of APPL1, an important intracellular binding partner for AdipoR, also significantly reduced the ability of adiponectin to prevent H/R-induced ROS generation and caspase 3 activity. In summary, H/R-induced ROS generation and activation of the intrinsic apoptotic pathway was prevented by adiponectin via AdipoR1/APPL1 signaling and increased anti-oxidant potential. © 2011 Park et al.published_or_final_versio

On the discovery of continuous truth: a semi-supervised approach with partial ground truths

In many applications, the information regarding to the same object can be collected from multiple sources. However, these multi-source data are not reported consistently. In the light of this challenge, truth discovery is emerged to identify truth for each object from multi-source data. Most existing truth discovery methods assume that ground truths are completely unknown, and they focus on the exploration of unsupervised approaches to jointly estimate object truths and source reliabilities. However, in many real world applications, a set of ground truths could be partially available. In this paper, we propose a semi-supervised truth discovery framework to estimate continuous object truths. With the help of ground truths, even a small amount, the accuracy of truth discovery can be improved. We formulate the semi-supervised truth discovery problem as an optimization task where object truths and source reliabilities are modeled as variables. The ground truths are modeled as a regularization term and its contribution to the source weight estimation can be controlled by a parameter. The experiments show that the proposed method is more accurate and efficient than the existing truth discovery methods

CVVF方法用于GPS多路径效应的研究

Author name used in this publication: 钟萍Author name used in this publication: 丁晓利, DING Xiao-liAuthor name used in this publication: 郑大伟Title in Traditional Chinese: CVVF方法用于GPS多路徑效應的研究Journal title in Traditional Chinese: 測繪學報2004-2005 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Basal paravian functional anatomy illuminated by high-detail body outline

Body shape is a fundamental expression of organismal biology, but its quantitative reconstruction in fossil vertebrates is rare. Due to the absence of fossilized soft tissue evidence, the functional consequences of basal paravian body shape and its implications for the origins of avians and flight are not yet fully understood. Here we reconstruct the quantitative body outline of a fossil paravian Anchiornis based on high-definition images of soft tissues revealed by laser-stimulated fluorescence. This body outline confirms patagia-bearing arms, drumstick-shaped legs and a slender tail, features that were probably widespread among paravians. Finely preserved details also reveal similarities in propatagial and footpad form between basal paravians and modern birds, extending their record to the Late Jurassic. The body outline and soft tissue details suggest significant functional decoupling between the legs and tail in at least some basal paravians. The number of seemingly modern propatagial traits hint that feathering was a significant factor in how basal paravians utilized arm, leg and tail function for aerodynamic benefit.published_or_final_versio

Vondrak滤波法用于结构振动与GPS多路径信号的分离

Author name used in this publication: 钟萍Author name used in this publication: 丁晓利, DING Xiao-liAuthor name used in this publication: 郑大伟Author name used in this publication: 陈武Title in Traditional Chinese: Vondrak 濾波法用於結構振動與GPS多路徑信號的分離Journal title in Traditional Chinese: 中南大學學報 (自然科學版)2006-2007 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

GPS结构振动监测数据滤波方法及其性能实验研究

Author name used in this publication: 钟萍Author name used in this publication: 丁晓利, DING Xiao-liAuthor name used in this publication: 郑大伟Author name used in this publication: 陈武Title in Traditional Chinese: GPS結構振動監測數據濾波方法及其性能實驗研究Journal title in Traditional Chinese: 測繪學報2006-2007 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

一种基于交叉证认技术的自适应小波变换及其在削减GPS多路径误差中的应用

Author name used in this publication: 钟萍Author name used in this publication: 丁晓利, DING Xiao-liAuthor name used in this publication: 郑大伟Author name used in this publication: 陈武Author name used in this publication: 黄丁发Title in Traditional Chinese: 一種基于交叉證認技術的自適應小波變換及其在削減GPS多路徑誤差中的應用Journal title in Traditional Chinese: 測繪學報2007-2008 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Premonitory phenomenon of El Nino event reflected in the observations of LOD and sea level

Journal title in Traditional Chinese: 科學通報 (英文版)2000-2001 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe