65,010 research outputs found
Critical role of canonical transient receptor potential channel 7 in initiation of seizures
Status epilepticus (SE) is a life-threatening disease that has been recognized since antiquity but still causes over 50,000 deaths annually in the United States. The prevailing view on the pathophysiology of SE is that it is sustained by a loss of normal inhibitory mechanisms of neuronal activity. However, the early process leading to the initiation of SE is not well understood. Here, we show that, as seen in electroencephalograms, SE induced by the muscarinic agonist pilocarpine in mice is preceded by a specific increase in the gamma wave, and genetic ablation of canonical transient receptor potential channel (TRPC) 7 significantly reduces this pilocarpine-induced increase of gamma wave activity, preventing the occurrence of SE. At the cellular level, TRPC7 plays a critical role in the generation of spontaneous epileptiform burst firing in cornu ammonis (CA) 3 pyramidal neurons in brain slices. At the synaptic level, TRPC7 plays a significant role in the long-term potentiation at the CA3 recurrent collateral synapses and Schaffer collateral-CA1 synapses, but not at the mossy fiber-CA3 synapses. Taken together, our data suggest that epileptiform burst firing generated in the CA3 region by activity-dependent enhancement of recurrent collateral synapses may be an early event in the initiation process of SE and that TRPC7 plays a critical role in this cellular event. Our findings reveal that TRPC7 is intimately involved in the initiation of seizures both in vitro and in vivo. To our knowledge, this contribution to initiation of seizures is the first identified functional role for the TRPC7 ion channel.Fil: Phelan, K. D.. University of Arkansas for Medical Sciences; Estados UnidosFil: Shwe, U. T.. University of Arkansas for Medical Sciences; Estados UnidosFil: Abramowitz, J.. National Institute of Environmental Health Sciences; Estados Unidos. Consejo Nacional de Investigaciones CientÃficas y Técnicas; ArgentinaFil: Birnbaumer, Lutz. National Institute of Environmental Health Sciences; Estados UnidosFil: Zheng, F.. University of Arkansas for Medical Sciences; Estados Unido
Permutable entire functions satisfying algebraic differential equations
It is shown that if two transcendental entire functions permute, and if one
of them satisfies an algebraic differential equation, then so does the other
one.Comment: 5 page
Ground state and finite temperature signatures of quantum phase transitions in the half-filled Hubbard model on a honeycomb lattice
We investigate ground state and finite temperature properties of the
half-filled Hubbard model on a honeycomb lattice using quantum monte carlo and
series expansion techniques. Unlike the square lattice, for which magnetic
order exists at T=0 for any non-zero , the honeycomb lattice is known to
have a semi-metal phase at small and an antiferromagnetic one at large .
We investigate the phase transition at T=0 by studying the magnetic
structureU_c/tC(T)U>U_cU <
U_cUC(T)U \approx U_c$.Comment: 11 pages, 19 figure
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Coil combination using linear deconvolution in k-space for phase imaging
Background: The combination of multi-channel data is a critical step for the imaging of phase and susceptibility contrast in magnetic resonance imaging (MRI). Magnitude-weighted phase combination methods often produce noise and aliasing artifacts in the magnitude images at accelerated imaging sceneries. To address this issue, an optimal coil combination method through deconvolution in k-space is proposed in this paper.
Methods: The proposed method firstly employs the sum-of-squares and phase aligning method to yield a complex reference coil image which is then used to calculate the coil sensitivity and its Fourier transform. Then, the coil k-space combining weights is computed, taking into account the truncated frequency data of coil sensitivity and the acquired k-space data. Finally, combining the coil k-space data with the acquired weights generates the k-space data of proton distribution, with which both phase and magnitude information can be obtained straightforwardly. Both phantom and in vivo imaging experiments were conducted to evaluate the performance of the proposed method.
Results: Compared with magnitude-weighted method and MCPC-C, the proposed method can alleviate the phase cancellation in coil combination, resulting in a less wrapped phase.
Conclusions: The proposed method provides an effective and efficient approach to combine multiple coil image in parallel MRI reconstruction, and has potential to benefit routine clinical practice in the future
Strongly Secure and Efficient Data Shuffle On Hardware Enclaves
Mitigating memory-access attacks on the Intel SGX architecture is an
important and open research problem. A natural notion of the mitigation is
cache-miss obliviousness which requires the cache-misses emitted during an
enclave execution are oblivious to sensitive data. This work realizes the
cache-miss obliviousness for the computation of data shuffling. The proposed
approach is to software-engineer the oblivious algorithm of Melbourne shuffle
on the Intel SGX/TSX architecture, where the Transaction Synchronization
eXtension (TSX) is (ab)used to detect the occurrence of cache misses. In the
system building, we propose software techniques to prefetch memory data prior
to the TSX transaction to defend the physical bus-tapping attacks. Our
evaluation based on real implementation shows that our system achieves superior
performance and lower transaction abort rate than the related work in the
existing literature.Comment: Systex'1
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